A5102846581- RNA modifications and cancer
- Cancer Genomics and Diagnostics
- Lung Cancer Treatments and Mutations
- Cancer-related gene regulation
- DNA Repair Mechanisms
- Metabolism and Genetic Disorders
- Head and Neck Cancer Studies
- Cancer-related Molecular Pathways
- Glycosylation and Glycoproteins Research
- Pancreatic function and diabetes
- Bladder and Urothelial Cancer Treatments
- Genomic variations and chromosomal abnormalities
- Molecular Biology Techniques and Applications
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Colorectal and Anal Carcinomas
- Ferroptosis and cancer prognosis
- Tissue Engineering and Regenerative Medicine
Shihezi University
2020
University of North Carolina at Chapel Hill
2011-2015
National Cancer Centre Singapore
2011
UNC Lineberger Comprehensive Cancer Center
2011
The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomavirus-associated tumours are dominated by helical domain mutations the oncogene PIK3CA, novel alterations involving loss TRAF3, amplification cycle gene E2F1. Smoking-related HNSCCs demonstrate near universal loss-of-function TP53 CDKN2A inactivation with frequent copy number including 3q26/28 11q13/22. A...
Background Lung adenocarcinoma (LAD) has extreme genetic variation among patients, which is currently not well understood, limiting progress in therapy development and research. LAD intrinsic molecular subtypes are a validated stratification of naturally-occurring gene expression patterns encompass different functional pathways patient outcomes. Patients may have incurred mutations alterations that led to the subtypes. We hypothesized co-occur with distinct tumors. Methodology/Principal...
Brain metastases are one of the most malignant complications lung cancer and constitute a significant cause related morbidity mortality worldwide. Recent years investigation suggested role LKB1 in NSCLC development progression, synergy with KRAS alteration. In this study, we systematically analyzed how alteration, measured by mutation, gene expression (GE) copy number (CN), associated brain metastasis NSCLC.Patients treated at University North Carolina Hospital from 1990 to 2009 provided...
Abstract Purpose: We evaluated X-ray repair complementing defective in Chinese hamster cells 1 (XRCC1) protein head and neck squamous cell carcinoma (HNSCC) patients association with outcome. Experimental Design: XRCC1 expression was assessed by immunohistochemical (IHC) staining of pretreatment tissue samples 138 consecutive HNSCC treated surgery (n = 31), radiation (15), (23), adjuvant chemoradiation (17), primary (51), palliative measures (1). Results: Patients high IHC 77) compared low...
In patients with bladder cancer (BC), the association between ST3 β-galactoside α-2,3-sialyltransferase 5 (ST3GAL5) expression and clinical outcomes, particularly regarding muscle-invasive disease, high tumor grade prognosis, remain unknown. present study, of ST3GAL5 its outcomes in BC was analyzed using various public bioinformatics databases. The difference healthy tissues also evaluated data from Oncomine database, Cancer Genome Atlas Gene Expression Omnibus database. differences muscle...
Abstract Background: Head and neck squamous cell carcinoma (HNSCC) is a complex heterogeneous disease for which the underlying genomic aberrations are unknown. Previous studies have suggested that chr11q13 region of interest in HNSCC. Independent suggest genes from this may be important – example, CTTN, CCND1, MYEOV, ANO1 but to our knowledge no focused on integration copy number data potential targets, or investigated prevalence (CNAs) clinical covariates. Human papillomavirus-associated...
Abstract Background: Head and neck squamous cell carcinoma (HNSCC) is a heterogeneous disease whose underlying etiology unknown. Chung et al. (Cancer Cell 2004; 5: 489 - 500) detected HNSCC gene expression (GE) subtypes, but to our knowledge these subtypes have not been discovered in other datasets. Moreover, we are aware of any studies that examined recurrent DNA copy number (CN) aberrations the context GE subtypes. Numerous shown exhibits gains chr3q26-28, region contains known oncogenes...
Abstract This study aims to construct recombinant lentiviral vectors containing the human stem cell leukemia (SCL) gene and investigate their in vitro transfection efficiency Interstitial Cells of Cajal (ICC) guinea pig bladders. In this study, SCL was successfully cloned, lentivirus GV287-SCL constructed. The titer 5 × 10 8 TU /mL. After transfecting ICCs with vector at different MOIs, optimal MOI determined be 10.0, time 3 days. amplification product group consistent target fragment,...