A5083667162- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- RNA modifications and cancer
- Monoclonal and Polyclonal Antibodies Research
- Lung Cancer Treatments and Mutations
- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Head and Neck Cancer Studies
- Cancer-related molecular mechanisms research
- Ear Surgery and Otitis Media
- Peptidase Inhibition and Analysis
- Infrared Thermography in Medicine
- Optical Imaging and Spectroscopy Techniques
- Inflammatory mediators and NSAID effects
- Vestibular and auditory disorders
- Ferroptosis and cancer prognosis
- Spectroscopy Techniques in Biomedical and Chemical Research
- Cancer-related Molecular Pathways
- Advanced Biosensing Techniques and Applications
- Cancer-related gene regulation
- Nanoparticle-Based Drug Delivery
- Genetic factors in colorectal cancer
- Advanced biosensing and bioanalysis techniques
- Lymphoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
Zhujiang Hospital
2013-2025
Southern Medical University
2013-2025
PLA Academy of Military Science
2024
Sun Yat-sen University
2008-2024
Beijing University of Chinese Medicine
2024
M. Akmullah Bashkir State Pedagogical University
2024
Huazhong University of Science and Technology
2024
Qingdao University of Technology
2022-2023
Qingdao University of Science and Technology
2023
Northeast Electric Power University
2023
Abstract Cancer prevention (chemoprevention) by using naturally occurring dietary agents has gained immense interest because of the broad safety window these compounds. However, many compounds are hydrophobic and poorly soluble in water. They frequently display low bioavailability, poor systemic delivery, efficacy. To circumvent this problem, we explored a novel approach toward chemoprevention nanotechnology to deliver luteolin, natural compound present green vegetables. We formulated...
A label-free, hyperspectral imaging (HSI) approach has been proposed for tumor margin assessment. HSI data, i.e., hypercube (x,y,λ), consist of a series high-resolution images the same field view that are acquired at different wavelengths. Every pixel on an image optical spectrum. In this pilot clinical study, pipeline machine-learning-based quantification method data was implemented and evaluated in patient specimens. Spectral features from were used classification cancer normal tissue....
Purpose: This study intends to investigate the feasibility of using hyperspectral imaging (HSI) detect and delineate cancers in fresh, surgical specimens patients with head neck cancers.Experimental Design: A clinical was conducted order collect image from (N = 36) undergoing resection. set machine-learning tools were developed quantify images resected tissue cancerous regions which validated by histopathologic diagnosis. More than two million reflectance spectral signatures obtained HSI...
Abstract One of the mechanisms antitumor activity green tea (−)‐epigallocatechin‐3‐gallate (EGCG) is associated with its effect on epidermal growth factor receptor (EGFR)‐mediated signaling transduction pathways. We investigated whether combining EGCG EGFR‐tyrosine kinase inhibitor (EGFR‐TKI) erlotinib may augment erlotinib‐induced cell inhibition squamous carcinoma head and neck (SCCHN) in a mouse xenograft model. In vitro studies 5 cancer lines revealed that synergistic by combination was...
Natural dietary agents have drawn a great deal of attention toward cancer prevention because their wide safety margin. However, single agent intervention has failed to bring the expected outcome in clinical trials; therefore, combinations chemopreventive are gaining increasingly popularity. In present study, we investigated combinatorial approach using two natural polyphenols, luteolin and EGCG, found that combination at low doses (at which induce minimal apoptosis) synergistically increased...
Human papillomavirus (HPV) is the causative agent of a subgroup head and neck cancer characterized by an intrinsic radiosensitivity. HPV initiates cellular transformation through activity E6 E7 proteins. expression necessary but not sufficient to transform host cell, as genomic instability required acquire malignant phenotype in HPV-initiated cells. This study reveals key role played oxidative stress promoting radiosensitivity HPV-positive cancer. By employing isogenic human cell model, we...
Abstract Purpose: Our previous work suggested that HER3 inhibition sensitizes head and neck squamous cell carcinoma (HNSCC) to EGFR with cetuximab. This study aimed define the role of in cetuximab resistance antitumor mechanisms EGFR/HER3 dual targeting HNSCC. Experimental Design: We treated cetuximab-resistant HNSCC UMSCC1-C parental UMSCC1-P lines anti-EGFR antibody cetuximab, anti-HER3 MM-121, their combination. assessed activities HER2, HER3, downstream signaling pathways by Western...
The proposed macroscopic optical histopathology includes a broad-band light source which is selected to illuminate the tissue glass slide of suspicious pathology, and hyperspectral camera that captures all wavelength bands from 450 950 nm. system has been trained classify each histologic based on predetermined pathology with having within range wavelengths. This technology able capture both spatial spectral data tissue. Highly metastatic human head neck cancer cells were transplanted nude...
The EGFR monoclonal antibody cetuximab is the only approved targeted agent for treating head and neck squamous cell carcinoma (HNSCC). Yet resistance to has hindered its activity in this disease. Intrinsic or compensatory HER3 signaling may contribute resistance. To investigate therapeutic benefit of combining MM-121/SAR256212, an anti-HER3 antibody, with HNSCC, we initially screened 12 HNSCC lines total phosphorylated levels four HER receptors. We also investigated combination MM-121...
We investigated the efficacy and underlying molecular mechanism of a novel chemopreventive strategy combining EGF receptor (EGFR) tyrosine kinase inhibitor (TKI) with cyclooxygenase-2 (COX-2I).We examined inhibition tumor cell growth by combined EGFR-TKI (erlotinib) COX-2I (celecoxib) treatment using head neck cancer lines preventive xenograft model. studied antiangiogenic activity these agents affected signaling pathways immunoblotting analysis in lysates immunohistochemistry (IHC) enzyme...
Hyperspectral imaging (HSI) is an modality that holds strong potential for rapid cancer detection during image-guided surgery. But the data from HSI often needs to be processed appropriately in order extract maximum useful information differentiates normal tissue. We proposed a framework hyperspectral image processing and quantification, which includes set of steps including preprocessing, glare removal, feature extraction, ultimately classification. The has been tested on images mice with...
Abstract Since the first surgery 50 years ago, cochlear implantation (CI) is major treatment for patients with severe sensorineural hearing loss. However, unexpected foreign body reactions (FBRs) after are reported in 90% of CI recipients, resulting formation fibrosis cochlea and progressive residual Zwitterion modification universally used to reduce bio‐fouling suppress FBRs but never CI. In present study, a zwitterionic coating developed, which composed poly sulfobetaine methacrylate (PSB)...
Skull base osteoradionecrosis (sbORN) is a severe complication of radiotherapy (RT) in patients with nasopharyngeal carcinoma (NPC) that can severely affect quality life (QOL) and may even be life-threatening. The etiology pathogenesis sbORN remain largely unknown or uncertain. Therefore, this study aimed to identify potential risk factors for by analyzing the laboratory assessments enable early clinical interventions. This retrospective case-control reviewed NPC who were pathologically...
The authors investigated whether coexpression and localization of E-cadherin (E-cad) epidermal growth factor receptor (EGFR) had predictive and/or prognostic correlations with lymph node metastasis survival in patients squamous cell carcinoma the head neck (SCCHN).Immunohistochemistry (IHC) archival tissue was performed to measure expression EGFR E-cad surgical specimens SCCHN (n = 143) that included primary tumors (PTs) positive nodes (Tu+Met) their paired metastases (LnMet), PTs negative...
Immunohistochemistry and an immunofluorescence technique was used to detect folate receptor expression in tissue samples cell lines of head neck squamous carcinoma, including 20 nasopharyngeal 16 laryngeal HNE-1, HNE-2, CNE-1, CNE-2, SUNE-1, 5-8F, Hep-2 lines. Iron staining, electron microscopy, magnetic resonance imaging were observe endocytosis folate-conjugated cisplatin-loaded nanoparticles (CDDP-FA-ASA-MNP) cultured cells transplanted tumors. As shown by immunohistochemistry, 83.3%...
Objective To investigate whether there is a correlation between the inflammatory state and pathogenesis clinical features of sudden hearing loss (SHL) by studying expression inflammation‐related cytokines in peripheral blood patients with SHL. Methods In this work, we analyzed cytokine profiles 48 analytes 38 SHL compared to healthy donors using multiplex immunoassay. This study used appropriate statistical methods screen for associated SHL, analyze their network correlation, relationship...