A5046079858- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Conducting polymers and applications
- Dielectric materials and actuators
- Advanced Sensor and Energy Harvesting Materials
- Polymer Surface Interaction Studies
- Noise Effects and Management
- Immune Response and Inflammation
- Acoustic Wave Resonator Technologies
- Ear Surgery and Otitis Media
- Corrosion Behavior and Inhibition
- Vestibular and auditory disorders
- Anodic Oxide Films and Nanostructures
- Extracellular vesicles in disease
- Neuroscience and Neural Engineering
Zhujiang Hospital
2021-2024
Southern Medical University
2021-2024
Abstract Since the first surgery 50 years ago, cochlear implantation (CI) is major treatment for patients with severe sensorineural hearing loss. However, unexpected foreign body reactions (FBRs) after are reported in 90% of CI recipients, resulting formation fibrosis cochlea and progressive residual Zwitterion modification universally used to reduce bio‐fouling suppress FBRs but never CI. In present study, a zwitterionic coating developed, which composed poly sulfobetaine methacrylate (PSB)...
Macrophages serve as the primary immune cell population and assume a pivotal role in response within damaged cochleae. Yet, origin of macrophages to noise exposure remain controversial. Here, we take advantage Ccr2RFP/+ Cx3cr1GFP/+ dual-reporter mice identify infiltrated tissue-resident macrophages. After exposure, reveal that activated resident change morphology, increase abundance, migrate region hair cells, leading loss outer cells damage ribbon synapses. Meanwhile, peripheral monocytes...
Cochlear implantation (CI) is the major treatment for severe sensorineural hearing loss. However, fibrotic tissue forming around electrodes reduces effectiveness of CI. Dexamethasone (DEX) usually applied routinely in perioperative cochlear (CI), but its diffusion inner ear after systemic administration limited. In present study, an electrode coated with polycaprolactone (PCL) loaded dexamethasone was developed a simple preparation process to maintain stability itself. The DEX-loaded PCL...
The cochlear implant (CI), an advanced electronic device replacing the entire function, is ultimate treatment for over 466 million people with disabling hearing loss. Infection after implantation a common and worrisome complication despite routine administration of antibiotic. bacterial biofilms formed on surface CI are main cause antibiotic failure. To solve this problem, we developed copper-containing zwitterionic coating consisting anti-adherent poly sulfobetaine methacrylate (PSB)...
With dexamethasone as the model drug and polycaprolactone (PCL) carrier material, a delivery coating for cochlear electrodes was prepared, to control fibrosis caused by implantation. A dexamethasone/poly (ε-caprolactone)-based electrode prepared using impregnation method. Preparation parameters were optimized, yielding 1 instance, time of 10 s, PCL concentration 10%. The characterized in vitro scanning electron microscopy, universal machine, high-performance liquid chromatography, CCK-8....
Sensorineural hearing loss is one of the most prevalent sensory deficits. Spiral ganglion neurons (SGNs) exhibit very limited regeneration capacity and their degeneration leads to profound loss. Mesenchymal stem cell-derived small extracellular vesicles (MSC-sEV) have been demonstrated repair tissue damage in various degenerative diseases. However, effects MSC-sEV on SGN remain unclear. In this study, we investigated efficacy for protection against ouabain-induced degeneration. were derived...
Abstract Background Macrophages serve as the primary immune cell population and assume a pivotal role in response within damaged cochleae, yet origin of macrophages to noise exposure remains controversial. Methods We generated Ccr2 RFP/+ Cx3cr1 GFP/+ dual-reporter mice identify infiltrated tissue-resident noise-exposed cochlea. Results Under steady-state, present Rosenthal's canal (SGNs), spiral ligament, basilar membrane adult After exposure, activated resident change morphology, increase...