A5043541884- Lymphoma Diagnosis and Treatment
- Head and Neck Cancer Studies
- Cancer Genomics and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- Global Cancer Incidence and Screening
- Viral-associated cancers and disorders
- Chronic Lymphocytic Leukemia Research
- Pancreatic and Hepatic Oncology Research
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cutaneous lymphoproliferative disorders research
- Economic and Financial Impacts of Cancer
- Lung Cancer Treatments and Mutations
- CAR-T cell therapy research
- Advanced Radiotherapy Techniques
- Breast Cancer Treatment Studies
- Brain Metastases and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Sarcoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Prostate Cancer Treatment and Research
Emory University
2016-2025
Piedmont Cancer Institute
2013-2025
Winship Cancer Institute
2015-2025
Cancer Institute (WIA)
2014-2024
Georgia Department of Public Health
2017-2024
Emory University Hospital
2024
Philadelphia College of Osteopathic Medicine
2022
University of Miami
2022
Centers for Disease Control and Prevention
2021
University of Pennsylvania
2021
Structural inequities have important implications for the health of marginalized groups. Neighborhood-level redlining and lending bias represent state-sponsored systems segregation, potential drivers adverse outcomes. We sought to estimate effect on breast cancer mortality explore differences by race.
BACKGROUND As systemic therapy has improved for locally advanced pancreatic cancer (LAPC), efforts to improve local control with optimal radiotherapy may be critical. Although conventionally fractionated radiation (CFRT) more recently shown a limited role in LAPC, stereotactic body (SBRT) is an emerging approach promising results. With no studies date comparing SBRT CFRT this study used the National Cancer Data Base (NCDB) evaluate these 2 modalities. METHODS NCDB, patients American Joint...
Glioblastoma (GBM) is the most aggressive malignant primary brain tumor in adults, with a median survival of 14.6 months. Recent efforts have focused on identifying clinically relevant subgroups to improve our understanding pathogenetic mechanisms and patient stratification. Concurrently, role immune cells microenvironment has received increasing attention, especially T tumor-associated macrophages (TAM). The latter are mixed population activated brain-resident microglia infiltrating...
We retrospectively compared the outcomes and toxicities of melanoma brain metastases (MBM) patients treated with BRAF inhibitors (BRAFi) stereotactic radiosurgery (SRS) SRS alone. identified 87 157 MBM alone from 2005 to 2013. Of these, 15 (17.2%) 32 (21.4%) received BRAFi therapy: three (20.0%) before SRS, two (13.3%) concurrent, 10 (66.7%) after SRS. Overall survival (OS) was between cohorts using product limit method. Intracranial were cumulative incidence competing risk for death....
Background Individuals of advanced age with comorbidities face a higher risk death from coronavirus disease 2019 (COVID‐19), especially once they are ventilator‐dependent. Respiratory decline in patients COVID‐19 is precipitated by lung‐mediated aberrant immune cytokine storm. Low‐dose lung radiation was used to treat pneumonia the pre‐antibiotic era. Radiation immunomodulatory effects may improve outcomes for select COVID‐19. Methods A single‐institution trial evaluating safety and efficacy...
Commonly used first-line (1L) treatments for mantle cell lymphoma include high-dose cytarabine-based induction followed by autologous stem-cell transplant (ASCT) younger patients and several chemoimmunotherapy regimens older patients. Continuous debates exist on the role of ASCT in maintenance rituximab (MR) after bendamustine plus (BR).Retrospective data from 4,216 with Flatiron Health electronic record-derived deidentified database diagnosed between 2011 2021, mostly US community oncology...
Vaccine-induced neutralizing antibodies (nAbs) play a critical role in protection from SARS CoV-2. Patients with B-cell malignancies including myeloma are at increased risk of COVID-19-related mortality and exhibit variable serologic response to the vaccine. The capacity vaccine-induced these patients neutralize CoV-2 or its variants is not known.Sera 238 multiple (MM) undergoing vaccination were analyzed. Antibodies against spike receptor-binding domain (RBD) viral nucleocapsid measured...
Patients with non-Hodgkin lymphoma including chronic lymphocytic leukemia (NHL/CLL) are at higher risk of severe SARS-CoV-2 infection. We investigated vaccine-induced antibody responses in patients NHL/CLL against the original strain and variants concern B.1.167.2 (Delta) B.1.1.529 (Omicron).
Entry of antigen-specific T cells into human tumors is critical for immunotherapy, but the underlying mechanisms are poorly understood. Here, we combined high-dimensional spatial analyses with in vitro and vivo modeling to study immune infiltration multiple myeloma (MM) its precursor monoclonal gammopathy undetermined significance (MGUS). Clustered tumor growth was a feature MM not MGUS biopsies, this pattern reproduced humanized mouse models. biopsies exhibited intralesional as well...
Abstract Poly ( ADP ) ribose polymerase PARP plays a key role in DNA repair and is highly expressed small cell lung cancer SCLC ). We investigated the therapeutic impact of inhibition . In vitro cytotoxicity veliparib, cisplatin, carboplatin, etoposide singly combined was determined by MTS 9 lines (H69, H128, H146, H526, H187, H209, DMS 53, 153, 114). Subcutaneous xenografts athymic nu/nu mice H146 H128 cells with relatively high low platinum sensitivity, respectively, were employed for vivo...
Background. While it is established that the incidence of cutaneous melanoma has risen over time in United States, trend for mucosal head and neck (MMHN) unknown. Methods. We used Surveillance, Epidemiology, End Results (SEER) database to determine trends MMHN from 1987 2009 States. determined annual percent change (APC) by weighted least squares joinpoint regression analysis. Results. increased (APC 2.4%; P < 0.01). Nasal cavity lesions 2.7%; 0.01) this duration, while non-nasal remained...
<ns4:p>For a typical medical research project based on observational data, sequential routine analyses are often essential to comprehend the data hand and draw valid conclusions. However, generating reports in SAS<ns4:sup>® </ns4:sup>for can be time-consuming tedious process, especially when dealing with large databases massive number of variables an iterative collaborative environment. In this work, we present general workflow database series SAS<ns4:sup>®</ns4:sup> macros that fits...
<ns4:p>For a typical medical research project based on observational data, sequential routine analyses are often essential to comprehend the data hand and draw valid conclusions. However, generating reports in SAS<ns4:sup>® </ns4:sup>for can be time-consuming tedious process, especially when dealing with large databases massive number of variables an iterative collaborative environment. In this work, we present general workflow database series SAS<ns4:sup>®</ns4:sup> macros that fits...
Phase 1 clinical trials have established low-dose, whole-lung radiation therapy (LD-RT) as safe for patients with coronavirus disease 2019 (COVID-19)-related pneumonia. By focally dampening cytokine hyperactivation, LD-RT may improve outcomes through immunomodulation.
Despite heterogeneous biology, similar surveillance schemas are utilized after resection of all pancreatic neuroendocrine tumors (PanNETs). Given concerns regarding excess radiation exposure and financial burden, our aim was to develop a prognostic score for disease recurrence guide individually tailored strategies.All patients with primary nonfunctioning, nonmetastatic well/moderately differentiated PanNETs who underwent curative-intent at 9-institutions from 2000 2016 were included (n =...
Abstract Paediatric high-grade gliomas (HGGs) account for the most brain tumour-related deaths in children and have a median survival of 12–15 months. One promising avenue research is development novel therapies targeting properties non-neoplastic cell-types within tumour such as associated macrophages (TAMs). TAMs are immunosuppressive promote malignancy adult HGG; however, paediatric medulloblastoma, exhibit anti-tumour properties. Much known about HGG, yet little them setting. This raises...
To examine COVID-19 mRNA vaccine-induced binding and neutralizing antibody responses in patients with non-small-cell lung cancer (NSCLC) to SARS-CoV-2 614D (wild type [WT]) strain variants of concern after the primary 2-dose booster vaccination.
Importance Inequities created by historical and contemporary mortgage discriminatory policies have implications for health disparities. The role of persistent discrimination (PMD) in breast cancer (BC) outcomes has not been studied. Objective To estimate the race-specific association redlining (HRL) with development BC subtypes late-stage disease a novel measure PMD mortality. Design, Setting, Participants This population-based cohort study used Georgia Cancer Registry data. A total 1764...