A5004300863- Higher Education Governance and Development
- Higher Education Research Studies
- Gender Diversity and Inequality
- SARS-CoV-2 and COVID-19 Research
- Academic Freedom and Politics
- American Constitutional Law and Politics
- SARS-CoV-2 detection and testing
- COVID-19 Impact on Reproduction
- Nanoparticle-Based Drug Delivery
- Trauma and Emergency Care Studies
- School Choice and Performance
- Mosquito-borne diseases and control
- Nanoplatforms for cancer theranostics
- Immunotherapy and Immune Responses
- COVID-19 Clinical Research Studies
- 3D Printing in Biomedical Research
- Influenza Virus Research Studies
- Injury Epidemiology and Prevention
- Mentoring and Academic Development
- Management and Organizational Studies
- Teacher Education and Leadership Studies
- Burn Injury Management and Outcomes
- Bone Tissue Engineering Materials
- Viral Infections and Vectors
- Animal Virus Infections Studies
Emory National Primate Research Center
2020-2024
Children's Healthcare of Atlanta
2020-2024
Emory University
2012-2024
Emory and Henry College
2012-2024
Johnson University
2024
Rutgers, The State University of New Jersey
2024
Rutgers Sexual and Reproductive Health and Rights
2024
Emory Healthcare
2024
University of North Carolina at Chapel Hill
2018-2023
North Carolina State University
2002-2023
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) omicron variant emerged in November 2021 and consists of several mutations within the spike. We use serum from mRNA-vaccinated individuals to measure neutralization activity against a live-virus assay. At 2-4 weeks after primary series vaccinations, we observe 30-fold reduction neutralizing omicron. Six months initial two-vaccine doses, sera naive vaccinated subjects show no In contrast, COVID-19-recovered 6 receiving...
The Omicron variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibits reduced susceptibility to vaccine-induced neutralizing antibodies, requiring a boost generate protective immunity. We assess the magnitude and short-term durability antibodies after homologous heterologous boosting with mRNA Ad26.COV2.S vaccines. All prime-boost combinations substantially increase neutralization titers Omicron, although boosted decline rapidly within months from peak response...
The Omicron variant of SARS-CoV-2 is raising concerns because its increased transmissibility and potential for reduced susceptibility to antibody neutralization. To assess the risk this existing vaccines, serum samples from mRNA-1273 vaccine recipients were tested neutralizing activity against compared neutralization titers D614G Beta in live virus pseudovirus assays. was 41-84-fold less sensitive than 5.3-7.4-fold when assayed with obtained 4 weeks after 2 standard inoculations 100 μg...
To examine COVID-19 mRNA vaccine-induced binding and neutralizing antibody responses in patients with non-small-cell lung cancer (NSCLC) to SARS-CoV-2 614D (wild type [WT]) strain variants of concern after the primary 2-dose booster vaccination.
As part of a multicenter study evaluating homologous and heterologous COVID-19 booster vaccines, we assessed the magnitude, breadth, short-term durability binding pseudovirus-neutralizing antibody (PsVNA) responses following single dose NVX-CoV2373 in adults primed with either Ad26.COV2.S, mRNA-1273, or BNT162b2 vaccines. as was immunogenic associated no safety concerns through Day 91. Fold-rises PsVNA titers from baseline (Day 1) to 29 were highest for prototypic D614G variant lowest more...
The primary cause of mortality for glioblastoma (GBM) is local tumor recurrence following standard-of-care therapies, including surgical resection. With most tumors recurring near the site resection, delivery chemotherapy at time surgery a promising strategy. Herein drug-loaded polymer scaffolds with two distinct degradation profiles were fabricated to investigate effect drug rate on GBM novel biopolymer, acetalated dextran (Ace-DEX), was compared commercially available polyester,...
A zinc-carnosine (ZnCar) metal-organic coordination polymer was fabricated in biologically relevant N-(2-hydroxyethyl)piperazine-N'-ethanesulfonic acid (HEPES) buffer for use as a vaccine platform. In vitro, ZnCar exhibited significantly less cytotoxicity than well-established zeolitic imidazolate framework (ZIF-8). Adsorption of CpG on the surface resulted enhanced innate immune activation compared to soluble CpG. The model antigen ovalbumin (OVA) encapsulated and acid-sensitive release...
ABSTRACT Zika virus (ZIKV) is a mosquito-borne flavivirus that caused an epidemic in the Americas 2016 and linked to severe neonatal birth defects, including microcephaly spontaneous abortion. To better understand host response ZIKV infection, we adapted 10× Genomics Chromium single-cell RNA sequencing (scRNA-seq) assay simultaneously capture viral mRNA. Using this assay, profiled antiviral landscape population of human monocyte-derived dendritic cells infected with at level. The bystander...
Current interstitial therapies for glioblastoma can overcome the blood-brain barrier but fail to optimally release therapy at a rate that stalls cancer reoccurrence. To address this lapse, acetalated dextran (Ace-DEX) nanofibrous scaffolds were used their unique degradation rates translate broad range of drug kinetics. A distinctive was illustrated via electrospun Ace-DEX or poly(lactic acid) (PLA) scaffolds. Scaffolds composed fast, medium, and slow degrading resulted in 14.1%, 2.9%, 1.3%...
Abstract The BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna) vaccines generate potent neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, the global emergence of SARS-CoV-2 variants with mutations in spike protein, principal antigenic target these vaccines, has raised concerns over activity vaccine-induced antibody responses. Omicron variant, which emerged November 2021, consists 30 within protein. Here, we used an authentic live virus...
The majority of research on administrative careers has been confined to accounts personal experiences or analyses one position, the presidency, from which knowledge concerning other extrapolated. implied career paradigm is summarized by Socolow, who says, Senior positions in academic administration have long almost exclusive province those served a substantial time academe, moving rung ladder next-most often professor chairman dean vice-president president [18, p. 42]. Other casts doubt this...
Throughout Europe, North America, and some other countries of the world years since 1960 have brought substantial increases in numbers percentages women students higher education. In countries, women's participation had been important for a number decades prior to 1960. France, Finland, Sweden, United States, example, made up rather large portions their respective student bodies, subject fluctuations during wars. however, are more recent perhaps remarkable that. Indeed, many it can be said...
Maternity care services were significantly altered with the start of global pandemic in 2020, challenging ways was provided for families during childbirth. This qualitative analysis focuses on maternity professionals' perceptions impact COVID-19 Michigan early pandemic. The question "How has impacted your work?" embedded into a survey focused unit culture process across Michigan. Directed content applied to open text responses identify themes. From April-June 1071 surveys completed by...
Abstract Encouraging women students and faculty to aspire leadership could be a common activity on most campuses.
Monocytes are known to play a critical role in dengue pathophysiology. However, which monocyte subset expresses what inflammatory mediator(s) and transcriptional features distinguish each of the vivo remain poorly understood. In this study we provide detailed analysis three human subsets healthy children with febrile illness. Notably, found that CD14+ CD16high intermediate from patients highly upregulated key genes involved mediating inflammation, endothelial dysfunction, vascular...
We investigated SARS-CoV-2 mRNA vaccine-induced binding and live-virus neutralizing antibody response in NSCLC patients to the wild type strain emerging Delta Omicron variants.82 53 healthy adult volunteers who received vaccines were included study. Blood was collected longitudinally, SARS-CoV-2-specific neutralization 614D (WT), B.1.617.2 (Delta), B.1.351 (Beta) B.1.1.529 (Omicron) variants evaluated by Meso Scale Discovery (MSD) assay Focus Reduction Neutralization Assay (FRNT)...
The influenza A virus causes substantial morbidity and mortality worldwide every year poses a constant threat of an emergent pandemic. Seasonal vaccination strategies fail to provide complete protection against infection due antigenic drift shift. universal vaccine targeting conserved epitope could substantially improve current strategies. ectodomain the matrix 2 protein (M2e) is highly between strains but also poorly immunogenic. Administration M2e immunostimulatory stimulator interferon...