A5103262978- Glioma Diagnosis and Treatment
- Brain Metastases and Treatment
- Meningioma and schwannoma management
- Radiomics and Machine Learning in Medical Imaging
- Advanced Radiotherapy Techniques
- Pancreatic and Hepatic Oncology Research
- Medical Imaging Techniques and Applications
- Lung Cancer Research Studies
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Cancer Genomics and Diagnostics
- Head and Neck Cancer Studies
- Prostate Cancer Treatment and Research
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Lymphoma Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Soft tissue tumor case studies
- Ferroptosis and cancer prognosis
- Ear and Head Tumors
- CNS Lymphoma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Urinary and Genital Oncology Studies
- Sarcoma Diagnosis and Treatment
Emory University
2016-2025
Winship Cancer Institute
2015-2024
Piedmont Cancer Institute
2015-2024
Cancer Institute (WIA)
2018-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Semmes Murphey Foundation
2021
Radiation Oncology Associates
2018
Southeast Radiation Oncology Group
2015
Carolina Neurosurgery and Spine Associates
2015
Levine Cancer Institute
2015
BACKGROUND: Stereotactic radiosurgery (SRS) is an increasingly common modality used with surgery for resectable brain metastases (BM). OBJECTIVE: To present a multi-institutional retrospective comparison of outcomes and toxicities preoperative SRS (Pre-SRS) postoperative (Post-SRS). METHODS: We reviewed the records patients who underwent resection BM either Pre-SRS or Post-SRS alone between 2005 2013 at 2 institutions. dose-reduction strategy based on tumor size, planned within 48 hours....
BACKGROUND As systemic therapy has improved for locally advanced pancreatic cancer (LAPC), efforts to improve local control with optimal radiotherapy may be critical. Although conventionally fractionated radiation (CFRT) more recently shown a limited role in LAPC, stereotactic body (SBRT) is an emerging approach promising results. With no studies date comparing SBRT CFRT this study used the National Cancer Data Base (NCDB) evaluate these 2 modalities. METHODS NCDB, patients American Joint...
Introduction: Treatment for primary central nervous system lymphoma (PCNSL) includes high-dose methotrexate (HD-MTX)-based systemic therapy. Multiple regimens exist with no clear standard of care. We evaluated the impact different therapies on PCNSL outcomes at a single institution. Materials and Methods: A total 95 consecutive patients from 2002 to 2021 were retrospectively reviewed. The overall survival (OS) progression-free (PFS) estimated by Kaplan–Meier method. log-rank test univariate...
Glioblastomas (GBMs) are aggressive brain tumors despite radiation therapy (RT) to 60 Gy and temozolomide (TMZ). Spectroscopic magnetic resonance imaging (sMRI), which measures levels of specific metabolites, can delineate regions at high risk for GBM recurrence not visualized on contrast-enhanced (CE) MRI. We conducted a clinical trial assess the feasibility, safety, efficacy sMRI-guided RT dose escalation 75 newly diagnosed GBMs.Our pilot (NCT03137888) enrolled patients 3 institutions...
BACKGROUND Postoperative management of prostate cancer with lymph node involvement (LNI) is controversial. Retrospective evidence supports the selective use radiotherapy (RT) after extended pelvic dissection. It unclear whether this generalizable to practice in United States, where dissection uncommon. The authors identified patients LNI who potentially could derive a survival benefit adjuvant RT plus androgen‐deprivation therapy (ADT). METHODS Patients N1M0 adenocarcinoma underwent radical...
Radical cystectomy currently remains the standard of care for muscle-invasive bladder cancer. However, surgery can be associated with considerable morbidity and mortality, including removal bladder. An alternative strategy is to preserve through concurrent chemoradiation following a maximal transurethral resection tumor. National protocols using bladder-preservation approach have demonstrated disease-specific outcomes comparable radical in selected patients, but these results not been...
Target delineation for radiation therapy treatment planning often benefits from magnetic resonance imaging (MRI) in addition to x-ray computed tomography (CT) due MRI's superior soft tissue contrast. MRI-based could reduce systematic MR-CT co-registration errors, medical cost, exposure, and simplify clinical workflow. However, MRI-only based is not widely used date because treatment-planning systems rely on the electron density information provided by CTs calculate dose. Additionally, air...
BACKGROUND Bevacizumab is a monoclonal antibody targeting vascular endothelial growth factor and approved for the treatment of patients with recurrent glioblastoma (GBM). Previous authors have reported differential response to bevacizumab on an individual basis. Bevacizumab‐induced hypertension well‐documented side effect, some reports suggested this occurrence be related outcome in other cancers. In current study, analyzed GBM who were treated based whether developed drug‐induced...
Due to glioblastoma's infiltrative nature, an optimal radiation therapy (RT) plan requires targeting infiltration not identified by anatomical magnetic resonance imaging (MRI). Here, high-resolution, whole-brain spectroscopic MRI (sMRI) is used describe tumor alongside and simulate the degree which it modifies RT target planning. In 11 patients with glioblastoma, data from preRT sMRI scans were processed give metabolite maps normalized contralateral white matter. Maps depicting choline...
Background Previous studies examining the time to initiate chemoradiation (CRT) after surgical resection of glioblastoma have been conflicting. To better define effect that timing adjuvant treatment may on outcomes, authors examined patients within National Cancer Database (NCDB) stratified by a validated prognostic classification system. Methods Patients with in NCDB who underwent surgery and CRT from 2004 through 2013 were analyzed. Radiation Therapy Oncology Group recursive partitioning...
BACKGROUND Stage II and III rectal cancers have been effectively treated with neoadjuvant chemoradiotherapy (NCRT) followed by definitive resection. Advancements in surgical technique systemic therapy prompted investigation of multiagent chemotherapy (NMAC) regimens the elimination radiation (RT). The objective current study was to investigate factors that predict for use NCRT versus NMAC compare outcomes using National Cancer Data Base (NCDB) select stage cancers. METHODS In NCDB, 21,707...
Targeted genetic studies can facilitate phenotypic analyses and provide important insights into development other complex processes. The SWI2/SNF2 DNA-dependent ATPase Domino (Dom) of Drosophila melanogaster, a component the Tip60 acetyltransferase complex, has been associated with wide spectrum cellular processes at multiple developmental stages. These include hematopoiesis, cell proliferation, homeotic gene regulation, histone exchange during DNA repair, Notch signaling. To explore wider...
Therapy of acute myeloid leukemia in older persons is associated with poor outcomes because intolerance to intensive therapy, resistant disease and co-morbidities. This multi-center, randomized, open-label, phase II trial compared safety efficacy three therapeutic strategies patients 65 years or over newly-diagnosed leukemia: 1) continuous high-dose lenalidomide (n=15); 2) sequential azacitidine (n=39); 3) only (n=34). The end point was 1-year survival. Median age 76 (range 66–87 years)....
Background: The combination of oral pentoxifylline (Ptx) and vitamin E (VitE) has been used to treat radiation-induced fibrosis soft tissue injury. Here, we review outcomes perform a radiomic analysis treatment effects in patients prescribed Ptx + VitE at our institution for the radiation necrosis (RN). Methods: A total 48 treated with stereotactic radiosurgery (SRS) had evidence RN MRI before after starting VitE. oncologist’s impression imaging electronic medical record was score response...
Objectives The patterns of care for salivary gland adenoid cystic carcinomas (ACC) are unknown. We sought to assess predictors receiving postoperative radiation and/or chemotherapy patients with nonmetastatic, definitively resected ACC, as well report unexpected nodal disease. Methods National Cancer Data Base was queried nonmetastatic ACC from 2004 2014. Logistic regression, Kaplan‐Meier, and Cox proportional‐hazard models were utilized. Propensity‐score matched analysis employed reduce...
For muscle-invasive bladder cancer, preserving chemoradiotherapy (BPCRT) has shown to be a viable alternative for patients with urothelial carcinoma (UCa). Traditionally cancer variant histology UCa or other tumors types involving the have worse outcomes and BPCRT been contraindicated. However, there is limited high level evidence this recommendation.
In the DDC feeding mouse model where liver cells proliferate, Mallory-Denk bodies (MDBs) form and later, after withdrawal, hepatocellular carcinomas (HCCs) develop (1). Similarly, patients who abuse alcohol alcoholic disease (ALD), MDBs (2) abstinence, HCCs (2). Also in many of HCCs, both ALD. Because this, it has been suggested that are a preneoplastic change formed balloon hepatocytes which transform into cancer (3-6). But there may be other links to process ALD-induced such as role...