A5103006967- Frailty in Older Adults
- Health disparities and outcomes
- Nutrition and Health in Aging
- Health Systems, Economic Evaluations, Quality of Life
- Geriatric Care and Nursing Homes
- Emergency and Acute Care Studies
- Asthma and respiratory diseases
- Dementia and Cognitive Impairment Research
- Obesity, Physical Activity, Diet
- Urban Transport and Accessibility
- Balance, Gait, and Falls Prevention
- Body Composition Measurement Techniques
- Physical Activity and Health
- Palliative Care and End-of-Life Issues
- Health Policy Implementation Science
- Community Health and Development
- Obesity and Health Practices
- Urban, Neighborhood, and Segregation Studies
- Health and Well-being Studies
- Musculoskeletal pain and rehabilitation
- Glycosylation and Glycoproteins Research
- Intensive Care Unit Cognitive Disorders
- Health and Wellbeing Research
- Healthcare Policy and Management
- Immune Response and Inflammation
Indiana University School of Medicine
2009-2023
Regenstrief Institute
2014-2023
Indiana University
2007-2023
University of Missouri
2022
Oklahoma State University Oklahoma City
2017-2021
Indiana University – Purdue University Indianapolis
2009-2020
University of Bristol
1983-2020
Messiah College
2010-2018
The Art Institutes
2018
University of Louisville
2018
Proteolysis mediated by the interleukin 1 beta-converting enzyme (ICE) homologues is an important mechanism of apoptotic process. The ICE homologue apopain/CPP-32/Yama (subsequently referred to as apopain) cleaves poly(ADP-ribose)polymerase (PARP) early during apoptosis. Additional apoptosis-specific protein cleavages have been observed in which direct involvement ICE-like proteases has postulated. These substrates include 70-kD component U1-ribonucleoprotein (U1-70kD), and catalytic subunit...
The U1 small nuclear ribonucleoprotein particle is essential for splicing of precursor mRNA, an activity that depends upon both the RNA and protein components particle. One U1-specific proteins functionally important in this reaction 70-kDa (U1-70kDa). We report here U1-70kDa specifically cleaved apoptotic cells, resulting generation a 40-kDa fragment. kinetics cleavage coincided with appearance cells morphology population, proportion fragment observed was markedly increased had become...
Older adults continue to be underrepresented in clinical research despite their burgeoning population the United States and worldwide. Physicians often propose treatment plans for older based on data from studies involving primarily younger, more‐functional, healthier participants. Major barriers recruitment of aging relate substantial health problems, social cultural barriers, potentially impaired capacity provide informed consent. Institutionalized offer another layer complexity that...
L-663,536 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid) is a potent inhibitor of leukotriene (LT) biosynthesis in intact human polymorphonuclear leukocytes (PMN) (IC 50 , 2.5 nM). Similarly, inhibited A23187-induced LTB 4 formation by rat peripheral blood and elicited PMN. At concentrations where inhibition occurred whole (1.1 μM), no effect was seen on cyclooxygenase or 12-lipoxygenase, an also observed washed platelets. The compound had porcine...
Objectives To determine how well the interview‐based, clinic‐friendly International Academy of Nutrition and Aging ( FRAIL ) frailty scale predicts future disability mortality in African American Health AAH cohort compared with Study Osteoporotic Fractures SOF scale, phenotype‐based Cardiovascular CHS comprehensive Frailty Index FI ). Design Longitudinal study. Setting Metropolitan St. Louis, Missouri. Participants is a population‐based panel study Americans (baseline age 49–65) from...
Observational field audits are recommended for public health research to collect data on built environment characteristics. A reliable, standardized alternative that uses publicly available information could provide the ability efficiently compare results across different study sites and time.This aimed assess inter-rater reliability of conducted using Google Street View imagery.In 2011, street segments from St. Louis Indianapolis were geographically stratified ensure representation...
Confusion regarding proper use of the terms rate and risk persists in literature. This has implications for modeling prognosis transition between health states decision analysis related techniques. The issue is complicated by plethora to risk. Although suggestion force probability as substitutes some appeal, change terminology itself unlikely solve all confusion or misuse terms. paper clarifies definitions estimations rates risks suggests critical factors analyst re member when using,...
A new quantitative cytometric technique, termed the ArrayScan™, is described and used to measure NF-κB nuclear translocation induced by interleukin (IL)-1 tumor necrosis factor-α (TNFα). The amount of p65 staining measured in both nuclei defined Hoechst 33342 labeling surrounding cytoplasmic area within a preselected number cells/well 96-well plates. Using this technique synchronously activated human chondrocytes or HeLa cells, was found move nucleus with half-time 7–8 min for 12–13...
Previous studies involving transfection of cDNAs for 5-lipoxygenase-activating protein (FLAP) and 5-lipoxygenase into osteosarcoma cells have shown that both these proteins are essential leukotriene synthesis (Dixon, R. A. F., Diehl, E., Opas, Rands, Vickers, P. J., Evans, J. Gillard, W., Miller, D. K. (1990) Nature 343, 282-284). In the present study we show FLAP is in a variety known to produce leukotrienes, but absent from number which do not synthesize leukotrienes. Furthermore,...
Emergency departments (EDs), similar to other health care environments, are concerned with improving the quality of patient care. Older patients comprise a large, growing, and particularly vulnerable subset ED users. The project objective was develop ED-specific indicators for older help practitioners identify gaps focus improvement efforts.The Society Academic Medicine (SAEM) Geriatric Task Force, including members representing American College Physicians (ACEP), selected three conditions...
Although persons with dementia are frequently hospitalized, relatively little is known about the health profile, patterns of care use, and mortality rates for patients who access in emergency department (ED). We linked data from our hospital system Medicare Medicaid claims, Minimum Data Set, Outcome Assessment Information Set to evaluate 175,652 ED visits made by 10,354 individuals 15,020 without over 11 years. Survival after associated charges were examined. Patients visited more...
Abstract Muramyl dipeptide (MDP), the microbial activator of nucleotide-binding oligomerization domain 2 (Nod2), induces NF-κB and MAPK activation, leading to production multiple anti-bacterial proinflammatory molecules. In addition, MDP has been implicated in IL-1β secretion through regulation caspase-1. However, mechanisms that mediate caspase-1 activation response stimulation remain poorly understood. We show here fluorescent molecules are internalized primary macrophages accumulate...
During a 34-month period, 12 cases of delayed traumatic intracerebral hematoma (DTICH) were diagnosed among 162 consecutive prospectively studied patients admitted to the Medical College Virginia with severe closed head injuries. All unresponsive command and unable utter formed words at time admission. The interval from injury diagnosis DTICH by computerized tomography (CT) was within 48 hours in 11 cases. Six had no decompressive surgery before development lesion. Four undergone then...
To evaluate the effectiveness of computer-assisted decision support in reducing potentially inappropriate prescribing to older adults.Randomized, controlled trial.An academic emergency department (ED) Indianapolis, Indiana, where computerized physician order entry was used write all medication prescriptions.Sixty-three physicians were randomized intervention (32 physicians) or control (31 group.Decision that advised against use nine medications and recommended safer substitute therapies.The...
OBJECTIVE : To evaluate the effects of a program case‐finding and liaison service for older patients visiting emergency department. DESIGN Nonrandomized controlled trial with systematically assembled intervention cohort matched control group. SETTING An urban teaching hospital. PARTICIPANTS There were 385 subjects aged 65 years by day visit, gender, age within 5 years. INTERVENTIONS Geriatric medical, dental social problems identified in geriatric nurse clinician using well validated...
The purpose of this study was to identify demographic, disease, health care, and psychosocial-spiritual factors associated with death distress (death-related depression anxiety). Cross-sectional baseline data from a randomized controlled trial were used. Outpatients (n=70) recruited an urban academic medical centre proprietary hospital. All patients had life-threatening conditions, including cancer; pulmonary, cardiac, liver, or kidney disease; HIV/AIDS; geriatric frailty. Measures distress,...