A5055492725- Diabetes and associated disorders
- Asthma and respiratory diseases
- Renal Transplantation Outcomes and Treatments
- Transplantation: Methods and Outcomes
- Pancreatic function and diabetes
- Synthesis and Characterization of Heterocyclic Compounds
- Diabetes Management and Research
- Respiratory and Cough-Related Research
- Lipoproteins and Cardiovascular Health
- Animal Nutrition and Physiology
- RNA Interference and Gene Delivery
- Grief, Bereavement, and Mental Health
- Pharmacological Effects and Assays
- Synthesis and Reactivity of Heterocycles
- NF-κB Signaling Pathways
- Genetic Associations and Epidemiology
- Genetic Neurodegenerative Diseases
- Endoplasmic Reticulum Stress and Disease
- Agricultural safety and regulations
- Hormonal Regulation and Hypertension
- RNA Research and Splicing
- HIV/AIDS drug development and treatment
- Synthesis of Organic Compounds
- Pediatric health and respiratory diseases
- Antiplatelet Therapy and Cardiovascular Diseases
King's College London
2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
1991-2010
University of Maryland, Baltimore
2004
Addenbrooke's Hospital
2000
University of Cambridge
2000
Wellcome Trust
2000
Yankton Rural Area Health Education Center
1986
University of South Dakota
1986
L-663,536 (3-[1-(4-chlorobenzyl)-3-t-butyl-thio-5-isopropylindol-2-yl]-2,2-dimethylpropanoic acid) is a potent inhibitor of leukotriene (LT) biosynthesis in intact human polymorphonuclear leukocytes (PMN) (IC 50 , 2.5 nM). Similarly, inhibited A23187-induced LTB 4 formation by rat peripheral blood and elicited PMN. At concentrations where inhibition occurred whole (1.1 μM), no effect was seen on cyclooxygenase or 12-lipoxygenase, an also observed washed platelets. The compound had porcine...
Background and purpose: Inhibition of cholesteryl ester transfer protein (CETP) with torcetrapib in humans increases plasma high density lipoprotein (HDL) cholesterol levels but is associated increased blood pressure. In a phase 3 clinical study, evaluating the effects atherosclerosis, there was an excess deaths adverse cardiovascular events patients taking torcetrapib. The studies reported herein sought to evaluate off‐target Experimental approach: Cardiovascular CETP inhibitors anacetrapib...
A genome scan for B10-derived loci that reduce the frequency of diabetes and insulitis in NOD mice demonstrated a large region (34 cM) linkage on proximal end chromosome 1. This locus was designated Idd5 encompassed candidate genes including Il1r1, Il1r2, Stat1, Stat4, Nramp1, Bcl2. In current study, we have confirmed existence by developing series congenic mouse strains are resistant to determined is actually two located within 9.4-cM interval. Idd5.1 1.5-cM portion interval contains...
The development of type I diabetes in the nonobese diabetic (NOD) mouse is under control multiple genes, one or more which linked to major histocompatibility complex (MHC). MHC class II region has been implicated disease development, with expression an I-E transgene NOD mice shown provide protection from insulitis and diabetes. To examine effect expressing I-E+ I-E- non-NOD on background, three congenic strains (NOD.H-2i5, NOD.H-2k, NOD.H-2h2, NOD.H-2h4, NOD.H-2i7, NOD.H-2b, respectively)...
Testing positive for COVID-19 was associated with higher rates of detrimental psycho-social and physical health outcomes. The pandemic caused unprecedented disruption to everyday life. This included major reconfiguration maternal, child, perinatal mental care services provision. study aimed investigate the experiences those who tested during pregnancy, labour birth, or early postnatal period. National on-line recruitment from across United Kingdom resulted in sixteen mothers being invited...
Members of the tumor necrosis factor receptor superfamily play an important role in initiation, expansion, and termination immune response. It has recently been demonstrated that one member this family, CD30, plays a central maintaining peripheral tolerance by controlling expansion autoreactive CD8+ T-cells. In present study, Cd30 was mapped to 5.6-cM interval on chromosome 4 containing type 1 diabetes susceptibility locus Idd9.2. We determined intron/exon structure sequenced exons, as well...
This report compares the antifertility activities in laying hens of various dithiocarbamates including fungicides thiram, ziram, zineb, maneb and ferbam, alcohol deterrent antabuse. Ziram at 200 ppm diet or thiram 125 stopped egg production within 2 days caused marked ovarian atrophy after 7 days. Ferbam levels between 600 antabuse 500 reduced but did not eliminate only slight regression. In contrast, zineb were without effect when tested ppm. The effects fully reversible, since treated with...
Abstract A number of novel C ‐nucleosides related to purine derivatives are described in which the moiety has been replaced by isosteric heterocycle, 8‐aminoimidazo[1,2‐α]pyrazine. The nucleosides prepared include ribo, 3′‐deoxy, 2′,3′‐dideoxy, and 2′,3′‐unsaturated derivatives. These represent containing acid stable glycosyl bonds they can be considered as analogs adenine‐ or 3‐deazaade‐nine‐containing nucleosides. Preparation parent ribonucleoside was accomplished reaction C‐l...
P1003 Aims: CCR5, the receptor for chemokines MIP-1α, MIP-1β and RANTES, is expressed constitutively on monocytes, macrophages activated T cells. In vivo studies in rodent demonstrate that this plays an important role both acute chronic allograft rejection. We have previously reported CCR5 inhibition with a highly selective antagonist prevents infiltration of CCR5+ CXCR3+ cells into rejecting allograft. Here we explore its rejection non-human primates when used context conventional...
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