A5053828204- Nicotinic Acetylcholine Receptors Study
- Healthcare and Venom Research
- Traditional Chinese Medicine Studies
- Cerebrovascular and Carotid Artery Diseases
- Neurological Disease Mechanisms and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Medical Research and Treatments
- Protein Hydrolysis and Bioactive Peptides
- Cardiac Ischemia and Reperfusion
- Pancreatic function and diabetes
- Metabolism, Diabetes, and Cancer
- Pregnancy and preeclampsia studies
- Cytokine Signaling Pathways and Interactions
- Appendicitis Diagnosis and Management
- Vascular Malformations Diagnosis and Treatment
- Alzheimer's disease research and treatments
- Venous Thromboembolism Diagnosis and Management
- Orthopedic Infections and Treatments
- Diabetes Management and Research
- MicroRNA in disease regulation
- Biochemical effects in animals
- Diabetic Foot Ulcer Assessment and Management
- Diabetes Treatment and Management
- Acute Ischemic Stroke Management
- Epigenetics and DNA Methylation
Northwest A&F University
2023-2024
South China University of Technology
2014-2023
Pfizer (United States)
2016-2023
Huazhong University of Science and Technology
2016-2023
Union Hospital
2023
Shihezi University
2013-2021
Jiangsu Hengrui Medicine (China)
2019-2021
Shandong University
2021
Tangshan Gongren Hospital
2021
Army Medical University
2018-2021
The cytokine TWEAK and its cognate receptor Fn14 are members of the TNF/TNFR superfamily upregulated in tissue injury to mediate local responses including inflammation remodeling. We found that various models kidney disease, expression (mRNA protein) is kidney. These include: lupus nephritis mouse (Nephrotoxic serum Transfer Nephritis MRL.Faslpr/lpr), acute (Ischemia reperfusion Folic acid injury), a ZSF-1 diabetic nephropathy rat model. levels correlate with disease severity as measured by...
Gestational exposure to nicotine affects brain development, leading numerous behavioural and physiological deficits in the offspring during adolescence. To analyse molecular mechanisms underlying these effects, a pathway-focused oligonucleotide microarray was used determine gene expression profiles five regions (i.e. amygdala, prefrontal cortex, nucleus accumbens, periventricular of hypothalamus, caudate putamen CPu) adolescent rats that received or saline gestation. Following appropriate...
Mesolimbic dopamine (DA) system lesion plays a key role in the pathophysiology of depression, and our previous study demonstrated that reduced microtubule (MT) stability aggravated nigrostriatal pathway impairment after intracerebral hemorrhage (ICH). This aimed to further investigate occurrence regularity depression-like behavior ICH determine whether maintaining MT stabilization could protect DA neurons ventral tegmental area (VTA) alleviate ICH. An intrastriatal injection 20 μl autologous...
Ionic liquid/ethanol was used in bamboo hydrolysis residue (BHR) to separate lignin and cellulose.
Hyperuricemia and dyslipidemia are involved in Cd nephrotoxicity. The aim of this study was to determine the effect quercetin, a dietary flavonoid with anti-hyperuricemic anti-dyslipidemic properties, on alteration renal UA transport system disorder lipid accumulation 3 6 mg/kg Cd-exposed rats for 4 weeks. exposure induced hyperuricemia XOR hyperactivity excretion dysfunction rats. Simultaneously, abnormal expression levels transport-related proteins including RST, OAT1, MRP4 ABCG2 were...
An efficient and green method for the modification of lignin by a low transition temperature mixture was used in synthesis phenol–furfural resins.
The present study investigated the synergistic effect of co‑administering fibroblast growth factor‑2 (FGF‑2) and bone morphogenetic protein‑2 (BMP‑2) on osteoblastic differentiation in C2C12 cells rats. murine myoblast represent a well‑accepted vitro model system to ability BMP‑2 alter cell lineage from myogenic osteogenic phenotype. potency was determined by alkaline phosphatase (ALP) Alizarin red S staining. ALP activity calcium concentrations were colorimetrically measured. Simultaneous...
Abstract Background The relationship between intestinal obstruction due to colorectal cancer (CRC) and the gut microbiota remains largely unknown. aim of this study was investigate potential association alterations in CRC presence obstruction. Methods Patients with or without were recruited compared using 1:1 propensity score matching (PSM). Total DNA from tumours adjacent normal tissues 84 patients 36 frozen tumour extracted amplified. 16S RNA sequencing used uncover differences composition...
Maternal smoking during pregnancy (MS) has long-lasting neurobehavioural effects on the offspring. Many MS-associated psychiatric disorders begin or change symptomatology adolescence, a period of continuous development central nervous system. However, underlying molecular mechanisms are largely unknown. Given that cell adhesion molecules (CAMs) modulate various neurotransmitter systems and associated with many disorders, we hypothesize CAMs altered by prenatal treatment nicotine, major...
Hyperhomocysteinemia is considered to be a significant risk factor in atherosclerosis and plays an important role it. The purpose of this study was determine the molecular mechanism blood monocyte chemoattractant protein-1 (MCP-1) promoter DNA hypomethylation formation induced by hyperhomocysteinemia, explore effect nuclear factor-κB (NF-κB)/DNA methyltransferase 1 (DNMT1) mechanism. atherosclerotic MCP-1 apolipoprotein E-deficient (ApoE(-/-)) wild-type C57BL/6J mice evaluated using lesion...
ZSF1 rats exhibit spontaneous nephropathy secondary to obesity, hypertension, and diabetes, have gained interest as a model system with potentially high translational value progressive human disease. To thoroughly characterize this model, better understand how closely it recapitulates disease, we performed resolution longitudinal analysis of renal disease progression in spanning from early end stage Analyses included metabolic endpoints, histology ultrastructure, evaluation urinary biomarker...
Background: The higher incidence of smoking among alcoholic subjects suggests the presence common molecular mechanisms underlying nicotine and alcohol use abuse. However, these are largely unknown. By using cultured fetal mouse cortical neurons as a model system, we sought to identify genes pathways that modulated in cells by ethanol, nicotine, or both. Methods: Primary cerebral cultures were prepared from brains 14‐day‐old C57BL/6 fetuses exposed ethanol (75 mM), (0.1 both for 5 consecutive...
Abstract Circulating miRNAs have been shown to serve as diagnostic/prognostic biomarkers in cancers and other diseases. However, the role of plasma Late-onset hypogonadism (LOH) diagnosis is still unknown. Using Illumina HiSeq2000 sequencing at discovery phase, then two-step validated by reverse transcriptase polymerase chain reaction (RT-PCR) assays verification phases. We verified that expression levels miR-125a-5p, miR-361-5p miR-133a-3p were significantly altered LOH group compared...
Diabetes mellitus in pregnancy has been known to affect the embryonic development of various systems, including cardiovascular and nervous systems. However, whether this disease could have a negative impact on respiratory system remains controversial. In study, we demonstrated that pregestational diabetes (PGDM)-induced defects lung mice are mainly characterized by changes morphological structure lung. Immunostaining Western blotting showed proliferation increased apoptosis decreased PGDM....