A5072346935- Colorectal Cancer Screening and Detection
- Gut microbiota and health
- Genetic factors in colorectal cancer
- Colorectal Cancer Surgical Treatments
- Colorectal Cancer Treatments and Studies
- Mycobacterium research and diagnosis
- Gastric Cancer Management and Outcomes
- Cancer Immunotherapy and Biomarkers
- Streptococcal Infections and Treatments
- Otolaryngology and Infectious Diseases
- Ferroptosis and cancer prognosis
- Colorectal and Anal Carcinomas
- Hepatocellular Carcinoma Treatment and Prognosis
- Metabolomics and Mass Spectrometry Studies
- Alcohol Consumption and Health Effects
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Tissue Engineering and Regenerative Medicine
- Cholangiocarcinoma and Gallbladder Cancer Studies
Union Hospital
2021-2024
Huazhong University of Science and Technology
2018-2024
Nanyang Institute of Technology
2021-2023
Creative Research Enterprises (United States)
2018
Union Hospital
2018
Union Hospital
2018
The proximal and distal subsites of colorectal cancer (CRC) have distinct differences in their embryonic origin, epidemiology, prognosis. Therefore, they are not considered as the same disease. However, possible difference microbial characterization two CRC is still unclear. In this study, we explored tumor microbiota diversity composition patients with (N = 187) CRCs 142). This was carried out on tissues adjacent using bacterial 16S rRNA sequencing. Kaplan-Meier method used to analyze...
Colorectal cancers (CRCs) with deficient DNA mismatch repair (dMMR) and proficient (pMMR) exhibit heterogeneous tumor characteristics, distinct responses to immunotherapy, different survival outcomes. However, it is unclear whether gut microbiota between CRCs MMR status. In this study, we used immunohistochemistry for four major proteins determine the status in 230 CRC patients. The was profiled cancerous adjacent normal tissues by using bacterial 16S rRNA sequencing. differences diversity,...
This is the first clinical research to systematically expound difference between gastric cancer (GC) individuals with
Abstract Background The relationship between intestinal obstruction due to colorectal cancer (CRC) and the gut microbiota remains largely unknown. aim of this study was investigate potential association alterations in CRC presence obstruction. Methods Patients with or without were recruited compared using 1:1 propensity score matching (PSM). Total DNA from tumours adjacent normal tissues 84 patients 36 frozen tumour extracted amplified. 16S RNA sequencing used uncover differences composition...
Liver metastasis is a major cause of mortality in patients with advanced stages colorectal cancer (CRC). The gut microbiota has been demonstrated to influence the progression liver diseases, potentially providing novel perspectives for diagnosis, treatment and research. However, microbial characteristics CRC (LM) no (NLM) have not yet fully established. In present study, high‑throughput 16S RNA sequencing technology was employed, order examine richness composition LM or NLM. A discovery...
Liver metastasis in colorectal cancer (CRC) is common and has an unfavorable prognosis. This study aimed to establish a functional nomogram model predict overall survival (OS) cancer-specific (CSS) patients with liver (CRCLM). A total of 9,736 CRCLM from 2010 2016 were randomly assigned training, internal validation, external validation cohorts. Univariate multivariate Cox analyses performed identify independent clinicopathologic predictive factors, was constructed CSS OS. Multivariate...
RimK-like family member B (RIMKLB) is an enzyme that post-translationally modulates ribosomal protein S6, which can affect the development of immune cells. Some studies have suggested its role in tumor progression. However, relationships among RIMKLB expression, survival outcomes, and tumor-infiltrating cells (TIICs) colorectal cancer (CRC) are still unknown. Therefore, we analyzed expression levels CRC normal tissues investigated correlations between TIICs as well impact on clinical...
Chemotherapy is not recommended for patients with deficient mismatch repair (dMMR) in colorectal cancer (CRC); therefore, assessing the status of MMR crucial selection subsequent treatment. This study aimed at building predictive models to accurately and rapidly identify dMMR. A retrospective analysis was performed Wuhan Union Hospital between May 2017 December 2019 based on clinicopathological data CRC. The variables were subjected collinearity, least absolute shrinkage operator (LASSO)...
Intestinal microbiota play a critical role in the development of colorectal cancer. However, little is known about structure and characteristics gut microbial cancer, especially locally advanced rectal cancer after neoadjuvant chemoradiation therapy.Here, we performed this study to evaluate between pathologic complete response (pCR) (n=12) non-pathological (Non-pCR) (n=45) tumor tissues from patients with therapy. In study, 16S rRNA gene sequencing was used detect diversity including Alpha...
Abstract Background: Chemotherapy is not recommended for patients with deficient mismatch repair(dMMR)in colorectal cancer(CRC), so assessing the status of MMR crucial selection subsequent treatment. Therefore, this study aims to build predictive models accurately and rapidly identify dMMR. Methods: A retrospective analysis based on clinicopathological data cancer from May 2017 December 2019 at Wuhan Union Hospital was performed. The variables were subjected co-linearity analysis, least...