A5101416428- Colorectal Cancer Surgical Treatments
- Molecular Biology Techniques and Applications
- Colorectal Cancer Screening and Detection
- Gut microbiota and health
- Autopsy Techniques and Outcomes
- Genetic factors in colorectal cancer
- Forensic and Genetic Research
- Cancer Genomics and Diagnostics
Huazhong University of Science and Technology
2021
Union Hospital
2021
Stony Brook Medicine
2018
Memorial Sloan Kettering Cancer Center
2016
The proximal and distal subsites of colorectal cancer (CRC) have distinct differences in their embryonic origin, epidemiology, prognosis. Therefore, they are not considered as the same disease. However, possible difference microbial characterization two CRC is still unclear. In this study, we explored tumor microbiota diversity composition patients with (N = 187) CRCs 142). This was carried out on tissues adjacent using bacterial 16S rRNA sequencing. Kaplan-Meier method used to analyze...
The last decade has seen a marked rise in the use of cancer tissues obtained from research autopsies. Such resources have been invaluable for studying evolution or mechanisms therapeutic resistance to targeted therapies. Degradation biomolecules is potential challenge usage post-mortem setting and remains incompletely studied. We analysed nucleic acid quality 371 different frozen tissue samples collected 80 patients who underwent autopsy, including eight normal types, primary metastatic...
Intestinal microbiota play a critical role in the development of colorectal cancer. However, little is known about structure and characteristics gut microbial cancer, especially locally advanced rectal cancer after neoadjuvant chemoradiation therapy.Here, we performed this study to evaluate between pathologic complete response (pCR) (n=12) non-pathological (Non-pCR) (n=45) tumor tissues from patients with therapy. In study, 16S rRNA gene sequencing was used detect diversity including Alpha...