A5040822787- Reproductive Biology and Fertility
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Gynecological conditions and treatments
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Sexual Differentiation and Disorders
- Reproductive Health and Contraception
- Ovarian cancer diagnosis and treatment
- Sperm and Testicular Function
- Preterm Birth and Chorioamnionitis
- Uterine Myomas and Treatments
- Pregnancy and preeclampsia studies
- Reproductive Health and Technologies
- Renal and related cancers
- TGF-β signaling in diseases
- Urologic and reproductive health conditions
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pregnancy and Medication Impact
- Ectopic Pregnancy Diagnosis and Management
- Endometrial and Cervical Cancer Treatments
- Hemostasis and retained surgical items
- Lipid metabolism and disorders
- Gestational Trophoblastic Disease Studies
- Urticaria and Related Conditions
St Mary's Hospital
2010-2022
Manchester University NHS Foundation Trust
2020-2022
University of Manchester
2005-2021
St. Mary's Hospital
2011-2021
St. Mary’s Hospital
2021
Miscarriage Association
2019
Tommy's
2019
University of Birmingham
2019
Tameside Hospital
2013
Royal Albert Edward Infirmary
2010
Does administration of recombinant human granulocyte colony stimulating factor (rhG-CSF) in the first trimester improve pregnancy outcomes, among women with a history unexplained recurrent loss? rhG-CSF administered did not outcomes loss. The only previous randomized controlled study miscarriage 68 primary found statistically significant reduction and improvement live birth rates. A further four observational studies where G-CSF was used population were identified literature, two which...
ObjectiveTo assess the role of variant p.Asn680Ser in follicle-stimulating hormone receptor (FSHR) gene determining ovarian response patients undergoing vitro fertilization (IVF) treatment.DesignProspective observational study.SettingTertiary referral center for reproductive medicine.Patient(s)Women (n = 421) their first cycle controlled stimulation IVF and 83 healthy, ethnically matched controls.Intervention(s)Baseline pelvic ultrasound blood tests taken on days 2 to 3 assessment baseline...
The aim of this study was to compare the effect low-dose metformin and rosiglitazone on clinical, biochemical, ultrasound features endothelial function in patients with polycystic ovary syndrome (PCOS). After randomisation, a group 17 women received 500 mg b.d. (MG) 18 4 o.d. (RG) for 3 months. Serum FSH, LH, testosterone, fasting glucose, insulin, IGF-1, IGFBP-3, CRP were measured at baseline follow-up. Ovarian scan microcirculation studies also performed. It found that there reduction...
Abstract STUDY QUESTION What is the clinical-effectiveness and safety of endometrial scratch (ES) procedure compared to no ES, prior usual first time in vitro fertilisation (IVF) treatment? SUMMARY ANSWER ES was safe but did not improve pregnancy outcomes when performed mid-luteal phase IVF cycle, with or without intracytoplasmic sperm injection (ICSI). WHAT IS KNOWN ALREADY an ‘add-on’ treatment that available women undergoing a cycle IVF, ICSI, despite lack evidence support its use....
Objectives: To determine if an association exists between the follicle-stimulating hormone receptor (FSHR) gene p.Asn680Ser polymorphism and polycystic ovary syndrome (PCOS) or with high anti-mullerian (AMH) levels without PCOS. Patients: Fifty-eight women PCOS, 24 AMH (>44.5 pmol/L) PCOS 80 healthy ethnically matched female controls. Main outcome measures: Prevalence of FSHR polymorphism, baseline serum response to ovulation induction clomiphene citrate. Results: The frequency genotypes...
Laparotomy and debulking surgery followed by chemotherapy have been the treatment of choice in late stage ovarian carcinoma. Developments chemotherapeutic management cancer resulted a change opinion as to optimal this disease. Many patients are now receiving initial trials place compare up front adjuvant surgery. Tissue diagnosis is required prior commencing chemotherapy. This article describes one method for accurately obtaining tumour biopsy. A retrospective case note review 14 women with...
Genetic variation may influence women's response to ovarian stimulation therapy. The purpose of this study was investigate any effects genetic variants in the anti-Müllerian hormone (AMH) and AMH type II receptor genes on response/treatment outcomes current markers reserve individuals undergoing vitro fertilisation (IVF) treatment. In prospective observational study, we genotyped c.146G>T, p.(Ile49Ser) AMHR2 -482A>G 603 unrelated women their first cycle controlled for IVF ICSI...
Endometrial receptivity has been the focus of continuous research for over eight decades; however, current clinical practice lacks an accurate test endometrial to allow prediction successful pregnancy. We aimed characterize metabolomic profiles women who suffered recurrent miscarriage using discovery metabolomics and set foundation development test.This was a prospective multicenter cohort study led by Tommy's National Centre Miscarriage Research in Birmingham. biopsies were obtained during...
Introduction Endometrial trauma commonly known as endometrial scratch (ES) has been shown to improve pregnancy rates in women with a history of repeated implantation failure undergoing vitro fertilisation (IVF), or without intracytoplasmic sperm injection (ICSI). However, the procedure not yet fully explored having IVF/ICSI for first time. This study aims examine effect performing an ES mid-luteal phase prior first-time cycle on chances achieving clinical and live birth. If can influence...
STUDY QUESTIONIs there any effect of the -9C>G variant in bone morphogenic protein-15 (BMP15) gene on ovarian response and/or current markers reserve patients undergoing vitro fertilization (IVF) treatment?