A5101790514- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Technologies
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Neurotransmitter Receptor Influence on Behavior
- Sports Performance and Training
- American Environmental and Regional History
- Injury Epidemiology and Prevention
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Receptor Mechanisms and Signaling
- Sperm and Testicular Function
- Innovations in Medical Education
- Health Sciences Research and Education
- Ovarian cancer diagnosis and treatment
- Pregnancy and Medication Impact
- Architecture, Design, and Social History
- Sports and Physical Education Research
- Diverse Educational Innovations Studies
- Historical Studies and Socio-cultural Analysis
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Muscle metabolism and nutrition
- Ectopic Pregnancy Diagnosis and Management
- Cystic Fibrosis Research Advances
- Neuroscience and Neuropharmacology Research
NSW Department of Communities and Justice
2024
Courtauld Institute of Art
2022
Newcastle upon Tyne Hospitals NHS Foundation Trust
2015-2021
Centre for Life
2004-2019
Royal Victoria Infirmary
1998-2019
Newcastle upon Tyne Hospital
2012-2018
Cornell University
2018
University of Nottingham
2010-2017
Nottingham Biomedical Research Centre
2017
Queen's Medical Centre
2017
Background and objectives Progesterone is essential to maintain a healthy pregnancy. Guidance from the Royal College of Obstetricians Gynaecologists Cochrane review called for definitive trial test whether or not progesterone therapy in first trimester could reduce risk miscarriage women with history unexplained recurrent (RM). The PROMISE was conducted answer this question. A concurrent cost-effectiveness analysis conducted. Design setting randomised, double-blind, placebo-controlled,...
Does administration of recombinant human granulocyte colony stimulating factor (rhG-CSF) in the first trimester improve pregnancy outcomes, among women with a history unexplained recurrent loss? rhG-CSF administered did not outcomes loss. The only previous randomized controlled study miscarriage 68 primary found statistically significant reduction and improvement live birth rates. A further four observational studies where G-CSF was used population were identified literature, two which...
A broad spectrum of GnRH-deficient phenotypes has been identified in individuals with both mono- and biallelic GNRHR mutations. The objective the study was to determine correlation between severity reproductive phenotype(s) number functional rare sequence variants GNRHR. Eight hundred sixty-three probands different forms GnRH deficiency, 46 family members 422 controls were screened for 70 subjects (32 patients 38 members) harboring mutations divided into four groups (G1-G4) based on...
Optimisation of the environment favourable for satisfactory ovarian response to stimulation and successful embryo implantation remains at core assisted conception programmes. The evidence base routine use different adjuvants, alone or in combination, women undergoing their first vitro fertilisation (IVF) treatment cycle those with poor prognosis is inadequate. aim this document update last review available literature carried out by British Fertility Society Policy Practice Committee (BFS...
BACKGROUND: Stromal leucocyte populations in human endometrium comprise T cells, macrophages, and phenotypically unusual endometrial granulated lymphocytes. Their proportions vary during the menstrual cycle and, particular, lymphocytes increase number late secretory phase. The stimulus responsible for these cyclical changes is unknown but it likely that steroid hormones oestrogen progesterone play a role. AIMS: To define further expression of hormone receptors by leucocytes non-pregnant...
This study aims to provide an estimate of women's risk ovarian hyperstimulation syndrome (OHSS) when undergoing superovulation donate eggs for research. is essential prerequisite appropriate informed consent. In the absence sufficiently large numbers egg donors assess risk, comparative data was obtained from women same protocol in vitro fertilization (IVF) treatment. this prospective 339 women, who developed >/=20 follicles after their first treatment cycle (total number cycles during period...
Background Unintentional injuries among 0- to 4-year-olds are a major public health problem incurring substantial NHS, individual and societal costs. However, evidence on the effectiveness cost-effectiveness of preventative interventions is lacking. Aim To increase base for thermal injury, falls poisoning prevention under-fives. Methods Six work streams comprising five multicentre case–control studies assessing risk protective factors, study measuring quality life injury costs, national...
Human endometrial leukocytes undergo regular cyclical changes during the menstrual cycle, with a striking increase in phenotypically unusual population of CD56+ CD16- granulated lymphocytes (eGLs) late secretory phase and early pregnancy. The factors that regulate this eGL numbers are unclear; their morphology, however, has led to suggestion they apoptosis at end cycle. Apoptosis, bcl-2 expression, proliferative activity were examined stroma normal cycling, progesterone-treated,...
BACKGROUND: The demand for sperm donors has continued despite the introduction of ICSI. This study was undertaken in light impending changes donor anonymity laws to evaluate recruitment process donors. METHODS: Retrospective analysis 1101 potential a tertiary referral centre between January 1994 and August 2003. main outcome measures were determine demographic details, rate reasons rejection RESULTS: majority applicants aged <36 years (88.07%), students (54.88%), without partner (53.47%),...
Mitochondrial disease is a disorder of energy metabolism that affects 1 in 4300 adults the UK. Pregnancy associated with physiological demands have implications for metabolism. We were interested to know how pregnancy was affected women mitochondrial disease, particularly those most common pathogenic mutation m.3243A>G.Retrospective case-comparison study.Sixty-seven genetically confirmed from UK Diseases Cohort and 69 unaffected participated.Participants answered questionnaires regarding...
Key content Male factors alone account for up to 30% of subfertile couples undergoing in vitro fertilisation. infertility may be due problems with sperm production or transport and also sexual dysfunction. The underlying cause most cases is idiopathic. Modifiable lifestyle can have an impact on male fertility, but medical treatments a limited value enhancing semen quality. Most are based assisted fertilisation techniques, rather than treatment the cause. number quality that recovered, either...
<h3>Objectives</h3> To assess the effectiveness of thermostatic mixing valves (TMVs) in reducing bath hot tap water temperature, acceptability TMVs to families and impact on time safety practices. <h3>Design</h3> Pragmatic parallel arm randomised controlled trial. <h3>Setting</h3> A social housing organisation Glasgow, Scotland, UK. <h3>Participants</h3> 124 with at least one child under 5 years. <h3>Intervention</h3> TMV fitted by a qualified plumber educational leaflets before fitting....
The UK national sperm donor shortage is well known. We aimed to analyse the trends in various aspects of programme at Newcastle Fertility Centre (NFC) between 2000 and 2010. A retrospective review assisted conception treatments with was performed. decline numbers donors recruited alongside a declining trend number patients treated insemination (DI) treatment cycles carried out apparent. There an accompanying rising IVF same-sex couples single women coming for treatment. transfer local...