A5063034542- Reproductive System and Pregnancy
- Ectopic Pregnancy Diagnosis and Management
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Endometriosis Research and Treatment
- Reproductive Biology and Fertility
- Pregnancy and preeclampsia studies
- Reproductive Health and Technologies
- Prenatal Screening and Diagnostics
- Pregnancy and Medication Impact
- Maternal and fetal healthcare
- Male Reproductive Health Studies
- Uterine Myomas and Treatments
- Vitamin D Research Studies
- Preterm Birth and Chorioamnionitis
- Sperm and Testicular Function
- Organ and Tissue Transplantation Research
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Gynecological conditions and treatments
- Sexual Differentiation and Disorders
- Pregnancy-related medical research
- Reproductive Health and Contraception
- Renal Transplantation Outcomes and Treatments
- Gestational Trophoblastic Disease Studies
University of Iowa
2019-2024
University of Iowa Hospitals and Clinics
2018-2022
University of Birmingham
2015-2020
University of Iowa Health Care
2020
RELX Group (United States)
2020
Aalborg University Hospital
2020
University Hospitals Birmingham NHS Foundation Trust
2020
University of Amsterdam
2020
University of Glasgow
2020
Heartlands Hospital
2020
Progesterone is essential for the maintenance of pregnancy. However, whether progesterone supplementation in first trimester pregnancy would increase rate live births among women with a history unexplained recurrent miscarriages uncertain.
Bleeding in early pregnancy is strongly associated with loss. Progesterone essential for the maintenance of pregnancy. Several small trials have suggested that progesterone therapy may improve outcomes women who bleeding pregnancy.We conducted a multicenter, randomized, double-blind, placebo-controlled trial to evaluate progesterone, as compared placebo, vaginal Women were randomly assigned receive suppositories containing either 400 mg or matching placebo twice daily, from time at which...
Background and objectives Progesterone is essential to maintain a healthy pregnancy. Guidance from the Royal College of Obstetricians Gynaecologists Cochrane review called for definitive trial test whether or not progesterone therapy in first trimester could reduce risk miscarriage women with history unexplained recurrent (RM). The PROMISE was conducted answer this question. A concurrent cost-effectiveness analysis conducted. Design setting randomised, double-blind, placebo-controlled,...
Does administration of recombinant human granulocyte colony stimulating factor (rhG-CSF) in the first trimester improve pregnancy outcomes, among women with a history unexplained recurrent loss? rhG-CSF administered did not outcomes loss. The only previous randomized controlled study miscarriage 68 primary found statistically significant reduction and improvement live birth rates. A further four observational studies where G-CSF was used population were identified literature, two which...
Background Progesterone is essential for a healthy pregnancy. Several small trials have suggested that progesterone therapy may rescue pregnancy in women with early bleeding, which symptom strongly associated miscarriage. Objectives (1) To assess the effects of vaginal micronised bleeding first 12 weeks (2) evaluate cost-effectiveness bleeding. Design A multicentre, double-blind, placebo-controlled, randomised trial Setting total 48 hospitals UK. Participants Women aged 16–39 years...
Vitamin D deficiency has been associated with an increased risk of abnormal pregnancy implantation leading to obstetric complications such as pre-eclampsia and fetal growth restriction. However, the effect vitamin on reproductive treatment outcomes in couples undergoing assisted is poorly understood. This study investigates association between women treatments? A prospective cohort conducted at a large tertiary teaching hospital, United Kingdom. Five hundred were recruited September 2013...
Abstract Problem Recurrent implantation failure (RIF) after multiple embryo transfers remains a vexing problem and immunomodulators have been used with conflicting results. This study aims to assess the effect of immunomodulation therapy on live birth rate (LBR) in women RIF undergoing assisted reproduction treatment (ART). Method design is retrospective cohort multicentre network private conception units UK. The included who had at least two failed attempts CARE fertility period from 1997...
Objective: To evaluate the dose-dependent effect of propofol in hemodynamic parameters and reproductive outcomes following In-Vitro Fertilization (IVF) oocyte retrieval (OR)Design: Retrospective cohort studySubjects: 1575 women who underwent their first OR under monitored anesthesia care (MAC) subsequent fresh embryo transfer (ET) between January 2016 through December 2022Exposure: Women study were categorized into five cohorts (cohorts A – E) based on increasing dose total μg/kg/min.Main...
Objectives To assess the cost‐effectiveness of progesterone compared with placebo in preventing pregnancy loss women early vaginal bleeding. Design Economic evaluation alongside a large multi‐centre randomised placebo‐controlled trial. Setting Forty‐eight UK NHS units. Population Four thousand one hundred and fifty‐three aged 16–39 years bleeding ultrasound evidence an intrauterine sac. Methods An incremental analysis was performed from National Health Service (NHS) Personal Social Services...
(Abstracted from Am J Obstet Gynecol 2020;223(2):167–176) Historically, a lack of methodologically strong and generalizable studies has limited policy makers recommending the use progesterone supplementation to improve outcomes in women at high risk miscarriage. The PROMISE PRISM trials were carried out rectify this generate robust evidence on role prevent
Abstract Study question What is the relative effectiveness and safety of existing COS protocols for women undergoing assisted reproductive technology (ART) treatment? Summary answer There was no difference in live birth between all protocols, but short antagonist may reduce ovarian hyperstimulation syndrome with predicted normal/high response. known already Controlled stimulation an essential step most ART cycles. It involves administration exogenous gonadotrophins to induce multifollicular...
Purpose of this retrospective study was to investigate if serum markers, men's age, interval since vasectomy, BMI, testicular size and smoking could predict the success epididymal or sperm aspiration (PESA/TESA) in vasectomized men. Forty-four consecutively performed PESA/TESA procedures were reviewed retrospectively. Motile retrieved from 77.3% procedures. Mean Inhibin-B (Inh-B) level tended be higher men who had motile compared those not (180.3 versus 126.2 pg/ml, p = 0.05). Univariate...
( N Engl J Med . 2019;380(19):1815–1824) This study aimed to determine whether the controversial use of progesterone therapy in women with early bleeding pregnancy could result a higher incidence live births than placebo. It was multicenter, randomized, double-blind, placebo-controlled trial evaluate progesterone, as compared placebo, vaginal pregnancy. Women received suppositories or from presentation 16 weeks if helps improve outcomes for