A5002200527- Endometriosis Research and Treatment
- Ectopic Pregnancy Diagnosis and Management
- Uterine Myomas and Treatments
- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Gynecological conditions and treatments
- Maternal and fetal healthcare
- Gestational Trophoblastic Disease Studies
- Immunotoxicology and immune responses
- Reproductive System and Pregnancy
- Animal testing and alternatives
- Ureteral procedures and complications
- Intraperitoneal and Appendiceal Malignancies
- Intestinal and Peritoneal Adhesions
- Ovarian function and disorders
- Pelvic floor disorders treatments
- Surgical Simulation and Training
- Minimally Invasive Surgical Techniques
- Cervical Cancer and HPV Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Reproductive Health and Contraception
- Historical Geography and Geographical Thought
- Carcinogens and Genotoxicity Assessment
- Eastern European Communism and Reforms
- Computational Drug Discovery Methods
Guy's and St Thomas' NHS Foundation Trust
2018-2023
King's College Hospital
2007-2021
Medical Trust Hospital
2021
St Thomas' Hospital
2017-2020
St. Thomas Hospital
2020
University of Birmingham
2019
Miscarriage Association
2019
University College London
2008-2018
University College Hospital
2008-2018
King's College London
2016
The IDEA (International Deep Endometriosis Analysis group) statement is a consensus opinion on terms, definitions and measurements that may be used to describe the sonographic features of different phenotypes endometriosis. Currently, it difficult compare results between published studies because authors use terms when describing same structures anatomical locations. We hope suggested herein will adopted in centers around world. This would result consistent nomenclature ultrasound location...
What is the prevalence of adenomyosis in a population women attending general gynaecological clinic?Adenomyosis was present 206 985 [20.9%; 95% confidence interval (CI): 18.5-23.6%] included study.Previous studies occurrence have been limited to who underwent hysterectomy, which likely overestimate its compared with women. There are no large prospective on adenomyosis, either or gynaecology clinic setting.This observational study set university teaching hospital between January 2009 and...
Bleeding in early pregnancy is strongly associated with loss. Progesterone essential for the maintenance of pregnancy. Several small trials have suggested that progesterone therapy may improve outcomes women who bleeding pregnancy.We conducted a multicenter, randomized, double-blind, placebo-controlled trial to evaluate progesterone, as compared placebo, vaginal Women were randomly assigned receive suppositories containing either 400 mg or matching placebo twice daily, from time at which...
Endometriosis is a common condition which causes pain and reduced fertility. Treatment can be difficult, especially for severe disease, an accurate preoperative assessment would greatly help in the managment of these patients. The objective this study to assess accuracy pre-operative transvaginal ultrasound scanning (TVS) identifying specific features pelvic endometriosis adhesions comparison with laparoscopy.Consecutive women clinically suspected or proven endometriosis, who were booked...
Tubal ectopic pregnancies can cause substantial morbidity or even death. Current treatment is with methotrexate surgery. Methotrexate fails in approximately 30% of women who subsequently require rescue Gefitinib, an epidermal growth factor receptor inhibitor, might improve the effects methotrexate. We assessed efficacy oral gefitinib methotrexate, versus alone, to treat tubal pregnancy.We performed a multicentre, randomised, double-blind, placebo-controlled trial across 50 UK hospitals....
The objective of this study was to examine the ability preoperative transvaginal ultrasound (TVS) scanning assess severity pelvic endometriosis.Consecutive women with clinically suspected or proven endometriosis, who were booked for laparoscopy, invited join study. endometriosis assessed preoperatively using TVS and findings compared results obtained by laparoscopy American Society Reproductive Medicine (ASRM) classification.In total, 201 had laparoscopies. Of these, no found at 62/201...
To investigate the association between ultrasound features of adenomyosis and severity menstrual pain.This was a prospective observational study set in general gynecology clinic university teaching hospital January 2009 2010. A total 718 consecutive premenopausal women aged 17 55 years attended underwent structured clinical transvaginal examinations accordance with protocol. Morphological on scan were recorded systematically. quantitative assessment pain made by completion numerical rating...
To prospectively evaluate ultrasound criteria for the diagnosis of pregnancy in rudimentary horn a unicornuate uterus (cornual pregnancy).This was prospective observational study over period 90 months tertiary referral center London teaching hospital. A cornual made when all following were met: (1) single interstitial portion Fallopian tube main uterine body; (2) gestational sac, mobile and separate from uterus, surrounded by myometrium; (3) vascular pedicle joining sac to uterus. In cases...
Abstract Objectives To describe the clinical and ultrasound characteristics of granulosa cell tumors (GCTs) ovary, to define appearance GCTs based on pattern recognition. Methods Databases four gynecological centers were searched identify patients with histologically proven who had undergone a standard preoperative examination. Results A total 23 women confirmed GCT identified. Twelve (52%) postmenopausal, nine (39%) fertile age two (9%) prepubertal. Clinical symptoms abdominal distension...
Is there any benefit to including the routine examination by ultrasound of bladder, ureters and kidneys women with endometriosis? The complete urinary tract suspected endometriosis is that ureteric endometriosis, or without hydronephrosis, can be detected which facilitates early intervention prevent nephropathy. Women get obstruction but no clear consensus on correct diagnostic technique. Ultrasound accurate at detecting bladder involvement has not been assessed previously. This was a...
To investigate the prevalence and location of pelvic adhesions in women with a history Cesarean section to identify risk factors for their formation symptoms associated presence.This was prospective observational study whom one or more sections had been performed > 12 months previously who attended gynecological ultrasound examination. In all women, both transvaginal transabdominal scans were order presence adhesions. Medical surgical recorded structured questionnaire used enquire about any...
Abstract Objectives To assess the value of pattern recognition for preoperative ultrasound diagnosis borderline ovarian tumors (BOTs). Methods This was a prospective study women who were referred to our regional cancer center with an adnexal mass on Level II (routine) gynecological scan. Women lesions uncertain nature III (expert) scan in tertiary center. The tumor method used differentiate between various types tumors. Morphological features suggestive BOTs were: unilocular cyst positive...
To determine how accurately and confidently examiners with different levels of ultrasound experience can classify adnexal masses as benign or malignant suggest a specific histological diagnosis when evaluating images using pattern recognition.Ultrasound selected were evaluated by 3 expert sonologists, 2 senior 4 junior trainees. They instructed to the recognition malignant, state level confidence which this classification was made diagnosis. Sensitivity, specificity, accuracy positive...
Fibroids are common, hormone-dependent, benign uterine tumors. They can cause significant morbidity and the symptoms depend largely on their size. The aim of this study was to describe natural history fibroids identify factors that may influence growth.This a retrospective longitudinal premenopausal women who were diagnosed with ultrasound examination. All underwent at least two transvaginal scans, which all performed by single operator. measured in three perpendicular planes mean diameter...
To investigate the feasibility of identifying pelvic segments normal ureters and measuring their size on standard transvaginal ultrasound examination.This was a prospective observational study from June to July 2012. All women in underwent examination performed for various indications either by an expert or intermediate-level operator. A standardized assessment organs performed, recording any congenital acquired uterine pathology ovarian abnormalities. Visualization both attempted all cases....
Submucous fibroids are a common cause of menstrual disturbance that can be treated by hysteroscopic resection. Preoperative patient selection is critical for the success surgery and it usually based on assessment fibroid protrusion into uterine cavity. Three-dimensional saline contrast sonohysterography (3D-SCSH) provides additional information about size location submucous fibroids, but has not yet been evaluated its usefulness in preoperative assessment. The aim this study was to examine...
Abstract Background Endometriosis affects 190 million women and those assigned female at birth worldwide. For some, it is associated with debilitating chronic pelvic pain. Diagnosis of endometriosis often achieved through diagnostic laparoscopy. However, when isolated superficial peritoneal (SPE), the most common subtype, identified during laparoscopy, limited evidence exists to support decision surgically remove via excision or ablation. Improved understanding impact surgical removal SPE...
The aim of this study was to assess the natural history ultrasonically diagnosed ovarian dermoid cysts in a large group women who were managed expectantly, and factors that associated with failure expectant management.Our database searched for on ultrasonography by single expert operator between 2001 2007 retrospective study. In opted management, demographic data including age, gravidity parity recorded. Indications scan, site cysts, dimensions outcomes management also recorded.Two hundred...
Abstract Objectives To determine the effect of an ultrasound training course on performance pattern recognition when used by less experienced examiners and to compare recognition, a logistic regression model scoring system estimate risk malignancy between with different levels experience. Methods Using images selected adnexal masses, two trainees classified masses as benign or malignant using both before after they had attended theoretical gynecological course. They also system, but only The...
To examine the reproducibility of assessment severity pelvic endometriosis by transvaginal sonography (TVS).This was a prospective observational study conducted from August 2006 to July 2009 in two academic departments obstetrics and gynecology. Women with clinically suspected or proven were invited join study. All patients included underwent TVS performed observers laparoscopic endometriosis. The ultrasound blinded each other's results. examined evaluation interobserver agreement for...