A5002078868- Reproductive Health and Technologies
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Biology and Fertility
- Ectopic Pregnancy Diagnosis and Management
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Ovarian function and disorders
- Reproductive Health and Contraception
- Gestational Trophoblastic Disease Studies
- Gynecological conditions and treatments
- Mitochondrial Function and Pathology
- Pluripotent Stem Cells Research
- Renal and related cancers
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Metabolism and Genetic Disorders
- Maternal and fetal healthcare
- Maternal and Perinatal Health Interventions
- Neuroendocrine regulation and behavior
- CRISPR and Genetic Engineering
- Microtubule and mitosis dynamics
- Molecular Biology Techniques and Applications
- Vascular Malformations Diagnosis and Treatment
- Endometrial and Cervical Cancer Treatments
- Forensic and Genetic Research
Newcastle upon Tyne Hospital
2012-2024
Newcastle upon Tyne Hospitals NHS Foundation Trust
2014-2024
Centre for Life
2004-2024
Newcastle University
2012-2024
Sri Karan Narendra Agriculture University, Jobner
2022
Royal Victoria Infirmary
2016-2021
Oxford Fertility
2021
University of Oxford
2021
Miscarriage Association
2019
University of Birmingham
2019
Bleeding in early pregnancy is strongly associated with loss. Progesterone essential for the maintenance of pregnancy. Several small trials have suggested that progesterone therapy may improve outcomes women who bleeding pregnancy.We conducted a multicenter, randomized, double-blind, placebo-controlled trial to evaluate progesterone, as compared placebo, vaginal Women were randomly assigned receive suppositories containing either 400 mg or matching placebo twice daily, from time at which...
Most human embryos are aneuploid. Aneuploidy frequently arises during the early mitotic divisions of embryo, but its origin remains elusive. Human zygotes that cluster their nucleoli at pronuclear interface thought to be more likely develop into healthy euploid embryos. Here, we show parental genomes with in each pronucleus within and bovine zygotes, clustering is required for reliable unification after fertilization. During migration intact pronuclei, polarize toward other a process driven...
BackgroundThe anti-progesterone drug mifepristone and the prostaglandin misoprostol can be used to treat missed miscarriage. However, it is unclear whether a combination of more effective than administering alone. We investigated treatment with plus would result in higher rate completion miscarriage compared alone.MethodsMifeMiso was multicentre, double-blind, placebo-controlled, randomised trial 28 UK hospitals. Women were eligible for enrolment if they aged 16 years older, diagnosed by...
Abstract Studies in the mouse demonstrate importance of fibroblast growth factor (FGF) and extra-cellular receptor tyrosine kinase (ERK) specification embryo-fated epiblast yolk-sac-fated hypoblast cells from uncommitted inner cell mass (ICM) prior to implantation. Molecular mechanisms regulating early lineages human development are comparatively unclear. Here we show that exogenous FGF stimulation leads expanded molecular marker expression, at expense epiblast. Conversely, specifically...
Abstract Human embryonic stem cells (hESC) promise tremendous potential as a developmental and cell therapeutic tool. The combined effort of stimulatory inhibitory signals regulating gene expression, which drives the tissue differentiation morphogenetic processes during early embryogenesis, is still very poorly understood. With scarcity availability human embryos for research, hESC can be used an alternative source to study embryogenesis. Hyaluronan (HA), simple hydrating sugar, present...
Background Progesterone is essential for a healthy pregnancy. Several small trials have suggested that progesterone therapy may rescue pregnancy in women with early bleeding, which symptom strongly associated miscarriage. Objectives (1) To assess the effects of vaginal micronised bleeding first 12 weeks (2) evaluate cost-effectiveness bleeding. Design A multicentre, double-blind, placebo-controlled, randomised trial Setting total 48 hospitals UK. Participants Women aged 16–39 years...
Abstract Acentrosomal meiosis in oocytes represents a gametogenic challenge, requiring spindle bipolarization without predefined bipolar cues. While much is known about the structures that promote acentrosomal microtubule nucleation, less mediate mammalian oocytes. Here, we show mouse oocytes, kinetochores are required for I. This process promoted by oocyte-specific, microtubule-independent enrichment of antiparallel crosslinker Prc1 at via Ndc80 complex. In contrast, II, cytoplasm contains...
Abstract Clothing serves several essential functions, including protection, identification, and adornment. Among the methods used to enhance fabrics, printing techniques play a significant role, while conventional like screen block are still commonly used. Recently, eco-printing has emerged as contemporary sustainable technique that utilizes plant materials create unique colors patterns on textiles. Mordants, particularly few Natural Mordants critical in this process they improve color...
Isolation of human embryonic stem cell lines has opened a promising and pioneering area basic applied medical research. The issues in relation to couples' decision donating their supernumerary embryos for research need be investigated further.We carried out prospective study 300 couples who underwent IVF/ICSI treatment cycles our unit. We analysed various factors contributing consent donate spare or preimplantation genetic diagnosis research.The majority (54%) consented surplus Couples...
Does age of the sperm donor have an effect on reproductive outcomes (live birth rate and miscarriage occurrence) insemination or in vitro fertilization treatment using donated sperm?Live occurrence assisted reproduction sperms was not found to be affected by donors up 45 years old.Literature outcome medically is scarce. Most researchers agree that semen parameters deteriorate with increasing paternal age. However, there no substantial evidence suggest this deterioration adversely affects...
The aim of this study was to evaluate clinicians' views managing women with first-trimester Recurrent Miscarriage within the UK compared RCOG guidance. An online survey 150 Association Early Pregnancy Units members conducted using SurveyMonkey™. Analysis limited UK-based respondents (102). Of three key investigations, 98% performed antiphospholipid antibodies (APA) screening, 93.1% karyotyping for subsequent miscarriages and 86.3% a pelvic ultrasound routinely. Other routine investigations...
Abstract STUDY QUESTION What is the clinical-effectiveness and safety of endometrial scratch (ES) procedure compared to no ES, prior usual first time in vitro fertilisation (IVF) treatment? SUMMARY ANSWER ES was safe but did not improve pregnancy outcomes when performed mid-luteal phase IVF cycle, with or without intracytoplasmic sperm injection (ICSI). WHAT IS KNOWN ALREADY an ‘add-on’ treatment that available women undergoing a cycle IVF, ICSI, despite lack evidence support its use....
To assess the cost-effectiveness of mifepristone and misoprostol (MifeMiso) compared with only for medical management a missed miscarriage.Within-trial economic evaluation model-based analysis to set findings in context wider evidence range comparators. Incremental costs outcomes were calculated using nonparametric bootstrapping reported acceptability curves. Analyses performed from perspective UK's National Health Service (NHS).Twenty-eight UK NHS early pregnancy units.A cohort 711 women...
Abstract STUDY QUESTION Are live birth (LB) and perinatal outcomes affected by the use of frozen own versus donor oocytes? SUMMARY ANSWER Treatment cycles using oocytes have a lower LB rate but risk low weight (LBW) as compared with oocytes. WHAT IS KNOWN ALREADY A rising trend oocyte cryopreservation has been noted internationally in creation banks freezing for later settings fertility preservation social egg freezing. Published literature on primarily utilised data from due to relative...
Objectives To assess the cost‐effectiveness of progesterone compared with placebo in preventing pregnancy loss women early vaginal bleeding. Design Economic evaluation alongside a large multi‐centre randomised placebo‐controlled trial. Setting Forty‐eight UK NHS units. Population Four thousand one hundred and fifty‐three aged 16–39 years bleeding ultrasound evidence an intrauterine sac. Methods An incremental analysis was performed from National Health Service (NHS) Personal Social Services...