A5032061643- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Ectopic Pregnancy Diagnosis and Management
- Gynecological conditions and treatments
- Ovarian function and disorders
- Reproductive Health and Technologies
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Biology and Fertility
- Maternal and fetal healthcare
- Ovarian cancer diagnosis and treatment
- Gestational Trophoblastic Disease Studies
- Endometrial and Cervical Cancer Treatments
- Reproductive System and Pregnancy
- Intestinal and Peritoneal Adhesions
- Delphi Technique in Research
- Pregnancy-related medical research
- Pelvic floor disorders treatments
- COVID-19 Impact on Reproduction
- Prenatal Screening and Diagnostics
- Hernia repair and management
- Neonatal Respiratory Health Research
- Menstrual Health and Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Reproductive Health and Contraception
- Pregnancy and Medication Impact
University College London
2016-2025
University College Hospital
2015-2025
London Women's Clinic
2015-2025
The Centre for Reproductive & Genetic Health
2020-2021
MRC Centre for Reproductive Health
2020-2021
University College London Hospitals NHS Foundation Trust
2020-2021
National Health Service
2020
Royal London Hospital
2015-2017
King's College School
2016
King's College Hospital
2007-2015
What is the prevalence of adenomyosis in a population women attending general gynaecological clinic?Adenomyosis was present 206 985 [20.9%; 95% confidence interval (CI): 18.5-23.6%] included study.Previous studies occurrence have been limited to who underwent hysterectomy, which likely overestimate its compared with women. There are no large prospective on adenomyosis, either or gynaecology clinic setting.This observational study set university teaching hospital between January 2009 and...
ABSTRACT Objectives To assess the efficacy of ultrasound‐guided suction curettage for management pregnancies implanted into lower uterine segment Cesarean section scar. Methods This was a retrospective study including women diagnosed with scar pregnancy at two large tertiary referral early units between 1997 and 2014. Surgical evacuation offered to selected presenting in first trimester ≤ 14 weeks' gestation. All procedures were performed transcervically under ultrasound guidance using...
Is the presence of adenomyosis associated with menorrhagia? There was no significant association between and menorrhagia, but there a positive correlation severity on ultrasound amount menstrual loss estimated using pictorial blood assessment charts. is consensus in literature regards to menorrhagia. Previous studies have been limited retrospective highly selected populations which mainly included women who underwent hysterectomy. are large prospective evaluating either general population or...
Endometriosis is a common condition which causes pain and reduced fertility. Treatment can be difficult, especially for severe disease, an accurate preoperative assessment would greatly help in the managment of these patients. The objective this study to assess accuracy pre-operative transvaginal ultrasound scanning (TVS) identifying specific features pelvic endometriosis adhesions comparison with laparoscopy.Consecutive women clinically suspected or proven endometriosis, who were booked...
Does maternal infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the first trimester affect risk of miscarriage before 13 week's gestation?
Abstract STUDY QUESTION What are the clinical and ethical challenges of performing ovarian stimulation oocyte cryopreservation in adolescents barriers to providing treatment? SUMMARY ANSWER Our study shows that, one largest case series date this population, post-pubertal as young age 13 years can undergo with a response comparable adults. WHAT IS KNOWN ALREADY Fertility preservation has not been well studied, little data available existing literature. Referrals for fertility increasing due...
Submucous fibroids are common benign tumours responsible for menorrhagia, subfertility and miscarriage. They can be readily removed by hysteroscopic transcervical resection of myoma (TCRM). To facilitate resection, pre-operative GnRH analogues have been suggested, but the value this treatment is uncertain. Our aim was to assess submucous fibroids. This a prospective, double-blind, placebo-controlled, randomized trial. Women found on three-dimensional saline infusion sonohysterography (3D...
To investigate the association between ultrasound features of adenomyosis and severity menstrual pain.This was a prospective observational study set in general gynecology clinic university teaching hospital January 2009 2010. A total 718 consecutive premenopausal women aged 17 55 years attended underwent structured clinical transvaginal examinations accordance with protocol. Morphological on scan were recorded systematically. quantitative assessment pain made by completion numerical rating...
Can a core outcome set to standardize selection, collection and reporting across future infertility research be developed?A minimum data set, known as has been developed for randomized controlled trials (RCTs) systematic reviews evaluating potential treatments infertility.Complex issues, including failure consider the perspectives of people with fertility problems when selecting outcomes, variations in definitions selective outcomes on basis statistical analysis, make results difficult...
Can the priorities for future research in infertility be identified?The top 10 four areas of male infertility, female and unexplained medically assisted reproduction ethics, access organization care people with fertility problems were identified.Many fundamental questions regarding prevention, management consequences remain unanswered. This is a barrier to improving received by those problems.Potential collated from an initial international survey, systematic review clinical practice...
To prospectively evaluate ultrasound criteria for the diagnosis of pregnancy in rudimentary horn a unicornuate uterus (cornual pregnancy).This was prospective observational study over period 90 months tertiary referral center London teaching hospital. A cornual made when all following were met: (1) single interstitial portion Fallopian tube main uterine body; (2) gestational sac, mobile and separate from uterus, surrounded by myometrium; (3) vascular pedicle joining sac to uterus. In cases...
To validate the efficacy and safety of our clinical protocol for expectant management selected women diagnosed with tubal ectopic pregnancy.This was a prospective observational study carried out in early pregnancy unit London inner-city university teaching hospital from 1(st) January 2008 to 31(st) May 2011. All presenting suspected complications were assessed clinically by transvaginal ultrasound. Those conclusive ultrasound diagnosis either surgical or management. Selection criteria...
To investigate the prevalence and location of pelvic adhesions in women with a history Cesarean section to identify risk factors for their formation symptoms associated presence.This was prospective observational study whom one or more sections had been performed > 12 months previously who attended gynecological ultrasound examination. In all women, both transvaginal transabdominal scans were order presence adhesions. Medical surgical recorded structured questionnaire used enquire about any...
Endometriosis is a common gynaecological disorder affecting 5–10% of women reproductive age who often experience chronic pelvic pain and infertility. Definitive diagnosis through laparoscopy, exposing patients to potentially serious complications, delayed. Non-invasive biomarkers are urgently required accelerate for triaging potential surgery. This retrospective case control biomarker discovery validation study used quantitative 2D-difference gel electrophoresis tandem mass tagging–liquid...
Fibroids are common, hormone-dependent, benign uterine tumors. They can cause significant morbidity and the symptoms depend largely on their size. The aim of this study was to describe natural history fibroids identify factors that may influence growth.This a retrospective longitudinal premenopausal women who were diagnosed with ultrasound examination. All underwent at least two transvaginal scans, which all performed by single operator. measured in three perpendicular planes mean diameter...
To investigate the feasibility of identifying pelvic segments normal ureters and measuring their size on standard transvaginal ultrasound examination.This was a prospective observational study from June to July 2012. All women in underwent examination performed for various indications either by an expert or intermediate-level operator. A standardized assessment organs performed, recording any congenital acquired uterine pathology ovarian abnormalities. Visualization both attempted all cases....
Submucous fibroids are a common cause of menstrual disturbance that can be treated by hysteroscopic resection. Preoperative patient selection is critical for the success surgery and it usually based on assessment fibroid protrusion into uterine cavity. Three-dimensional saline contrast sonohysterography (3D-SCSH) provides additional information about size location submucous fibroids, but has not yet been evaluated its usefulness in preoperative assessment. The aim this study was to examine...
Can consensus definitions for the core outcome set infertility be identified in order to recommend a standardized approach reporting?Consensus individual outcomes, contextual statements, and reporting table have been developed.Different exist outcomes infertility. This variation increases opportunities researchers engage with selective reporting, which undermines secondary research compromises clinical practice guideline development.Potential were by systematic review of definition...
Objective Evaluate the impact of COVID-19 pandemic on access to contraception and pregnancy intentions. Design Nationwide prospective cohort study. Setting United Kingdom. Participants Women in UK who were pregnant between 24 May 31 December 2020. Main outcome measures Access level intentions, using London Measure Unplanned Pregnancy (LMUP) women whose last menstrual period was before or after 1 April While official date first lockdown 23 March, we used ensure that those post-lockdown group...