A5006661478- Menopause: Health Impacts and Treatments
- Estrogen and related hormone effects
- Global Maternal and Child Health
- Ectopic Pregnancy Diagnosis and Management
- Thyroid Disorders and Treatments
- Reproductive Health and Contraception
- Phytoestrogen effects and research
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Pregnancy and Medication Impact
- Menstrual Health and Disorders
- Environmental Toxicology and Ecotoxicology
- Maternal and Perinatal Health Interventions
- Ovarian cancer diagnosis and treatment
- Biochemical effects in animals
- Folate and B Vitamins Research
- Electrochemical sensors and biosensors
- Adolescent Sexual and Reproductive Health
- Aquaculture Nutrition and Growth
- Antioxidant Activity and Oxidative Stress
- Neuropeptides and Animal Physiology
- Enzyme Catalysis and Immobilization
- Thyroid Cancer Diagnosis and Treatment
- Trace Elements in Health
- Gynecological conditions and treatments
Heartlands Hospital
2010-2023
University Hospitals Birmingham NHS Foundation Trust
2019-2021
NIHR Surgical Reconstruction and Microbiology Research Centre
2019-2020
Heart of England NHS Foundation Trust
2006-2017
Solihull Hospital
2004-2017
Kaiser Permanente San Francisco Medical Center
2017
Kaiser Permanente Oakland Medical Center
2011-2016
North American Menopause Society
2012-2014
Maulana Azad National Institute of Technology
2014
San Francisco General Hospital
2008
Progesterone is essential for the maintenance of pregnancy. However, whether progesterone supplementation in first trimester pregnancy would increase rate live births among women with a history unexplained recurrent miscarriages uncertain.
Thyroid peroxidase antibodies are associated with an increased risk of miscarriage and preterm birth, even when thyroid function is normal. Small trials indicate that the use levothyroxine could reduce incidence such adverse outcomes.We conducted a double-blind, placebo-controlled trial to investigate whether treatment would increase live-birth rates among euthyroid women who had history or infertility. A total 19,585 from 49 hospitals in United Kingdom underwent testing for function. We...
Objectives To determine, first, the prevalence and severity of various symptoms related to estrogen deficiency in women within a few years receiving treatment for breast cancer, second, how perceive effects these on their quality life and, third, what measures have been taken relieve vasomotor symptoms.
BackgroundThe anti-progesterone drug mifepristone and the prostaglandin misoprostol can be used to treat missed miscarriage. However, it is unclear whether a combination of more effective than administering alone. We investigated treatment with plus would result in higher rate completion miscarriage compared alone.MethodsMifeMiso was multicentre, double-blind, placebo-controlled, randomised trial 28 UK hospitals. Women were eligible for enrolment if they aged 16 years older, diagnosed by...
Background and objectives Progesterone is essential to maintain a healthy pregnancy. Guidance from the Royal College of Obstetricians Gynaecologists Cochrane review called for definitive trial test whether or not progesterone therapy in first trimester could reduce risk miscarriage women with history unexplained recurrent (RM). The PROMISE was conducted answer this question. A concurrent cost-effectiveness analysis conducted. Design setting randomised, double-blind, placebo-controlled,...
Tubal ectopic pregnancies can cause substantial morbidity or even death. Current treatment is with methotrexate surgery. Methotrexate fails in approximately 30% of women who subsequently require rescue Gefitinib, an epidermal growth factor receptor inhibitor, might improve the effects methotrexate. We assessed efficacy oral gefitinib methotrexate, versus alone, to treat tubal pregnancy.We performed a multicentre, randomised, double-blind, placebo-controlled trial across 50 UK hospitals....
BackgroundChronic pelvic pain affects 2–24% of women worldwide and evidence for medical treatments is scarce. Gabapentin effective in treating some chronic conditions. We aimed to measure the efficacy safety gabapentin with no obvious pathology.MethodsWe performed a multicentre, randomised, double-blind, placebo-controlled randomised trial 39 UK hospital centres. Eligible participants were (with or without dysmenorrhoea dyspareunia) at least 3 months duration. Inclusion criteria 18–50 years...
Abstract Objective To describe the prevalence of and factors associated with different thyroid dysfunction phenotypes in women who are asymptomatic preconception. Design Observational cohort study. Setting A total 49 hospitals across United Kingdom between 2011 2016. Participants Women aged 16 to 41years history miscarriage or subfertility trying for a pregnancy. Methods Prevalences 95% confidence intervals (CIs) were estimated using binomial exact method. Multivariate logistic regression...
Does administration of recombinant human granulocyte colony stimulating factor (rhG-CSF) in the first trimester improve pregnancy outcomes, among women with a history unexplained recurrent loss? rhG-CSF administered did not outcomes loss. The only previous randomized controlled study miscarriage 68 primary found statistically significant reduction and improvement live birth rates. A further four observational studies where G-CSF was used population were identified literature, two which...
South Asian populations represent the largest minority ethnic group in UK. Subjective well-being (depressed mood and life satisfaction) first generation mid-aged immigrants originating from Indian subcontinents (UKA) is examined compared to that of UK Caucasian (UKC) (resident Delhi) (DEL) women. women (UKA DEL) reported higher levels depressed than UKC sample, but UKA samples were more satisfied with their lives Delhi sample. Life satisfaction was associated country residence depression...
Malignant ovarian germ cell tumors (MOGCT) are rare, accounting for 5% of all malignancies. In the first two decades life, almost 70% and these one-third malignant. Bilateral involvement in MOGCT is very rare. This case presented a unique challenge fertility-sparing surgery MOGCT. Although recommended even advanced stages if fertility desired, bilaterality disease precluded option index case. Neoadjuvant chemotherapy has been attempted patients with malignant extensive intra-abdominal...
Objectives First, to examine the experience of menopause and quality life in a migrated Asian population from Indian subcontinent living Birmingham, UK, and, second, compare their with matched sample Caucasian women same geographical area also similar socioeconomic background Delhi, India.Methods In this cross-sectional study 153 peri- postmenopausal aged 45–55 years, 52 originating Birmingham (UKA, mean age 51.4 years), 51 (UKC, 52.3 years) 50 India (DEL, 49.72 were interviewed collect...
We previously found differences in experience of menopausal symptoms between a migrated Asian sample women from the Indian subcontinent living UK (UKA), and matched samples Caucasian (UKC) Delhi, India (DEL). This study aims to explain these using quantitative qualitative methods.A total 153 peri- postmenopausal aged 45-55 years (52 UKA, 51 UKC 50 DEL) were interviewed about their menopause, lifestyle health. The current combines analysis potential predictors (sociodemographic variables,...
Objective To examine the relationship between climate (including altitude, temperature, humidity and annual range of temperature) experience hot flushes night sweats amongst Spanish-speaking mid-aged women living in five urban centers.Methods A total 896 peri- postmenopausal from centers Chile (Santiago de Chile), Ecuador (Guayaquil Quito), Panama (Panama City) Spain (Madrid) completed questionnaires eliciting information about sociodemographics, (prevalence, frequency problem-rating),...
The aim of the study was to assess continuation rates and satisfaction among post-partum intrauterine device (PPIUD) accepters.This prospective observational comprised 591 Zambian women who underwent PPIUD insertion at sites Society for Family Health, Lusaka, Zambia. were contacted 6-12 months after asked return clinic interview examination. If IUD strings not visible, an ultrasound performed. Participants about their with PPIUD. Main outcome measures short-term reported complications...
To determine, first, the effects of menopausal status on circulating calcitonin gene-related peptide (CGRP) levels and, second, correlation between CGRP and biomarkers for cardiovascular disease.Cross-sectional study healthy premenopausal postmenopausal women volunteers admitted elective benign abdominal surgery in a district general hospital. All were non-smokers, had no history endocrinological problems not receiving any hormone therapy. Fasting blood samples (premenopausal (n = 45):...
In Brief Objective: To compare serum 17β-estradiol (E2), estrone (E1), sulfate, follicle-stimulating hormone, luteinizing sex hormone-binding globulin, vaginal pH, and the maturation indices in women using a low-dose transdermal patch releasing 14 μg of E2 per day ring 7.5 day. Design: Twenty-four postmenopausal were randomly assigned to either (n = 12) or for 12-week study period. Serum E2, E1, globulin measured by immunoassay at baseline 6 12 weeks. Vaginal pH was determined cytologic...
Calcitonin gene-related peptide (CGRP) is a vasoactive, proinflammatory neuropeptide implicated in the pathogenesis of cardiovascular disease. Elevated CGRP levels during hot flushes and pregnancy suggest that reproductive hormones may influence secretion. related protein adrenomedullin (ADM) function through adipose tissue-mediated effects, since tissue an important site cytokine production main for estrogen after menopause. This study examined mRNA expression CGRP, ADM, receptor...
Objective To examine the relationships between climate (season, temperature, humidity), lifestyle, health, mood and beliefs experience of hot flushes night sweats amongst mid-aged women living in eight urban Indian centers.Methods A total 717 peri- postmenopausal women, aged 45–55 years, from centers different regions India were included. Data collected during both summer winter months. Participants completed questionnaires eliciting information about sociodemographics, (prevalence,...
To examine the relationships between temperature, season (summer versus winter), lifestyle, health, mood, beliefs, and experience of hot flushes night sweats (HFNS), amongst mid-aged women living in United Arab Emirates (UAE).The UAE climate is hyper-arid, being a desert climate, with warm winters summers. A total 372 peri- postmenopausal women, aged from 45 to 55 years, urban regions were included. Data collected during both summer winter months. Participants completed questionnaires...
To assess the cost-effectiveness of mifepristone and misoprostol (MifeMiso) compared with only for medical management a missed miscarriage.Within-trial economic evaluation model-based analysis to set findings in context wider evidence range comparators. Incremental costs outcomes were calculated using nonparametric bootstrapping reported acceptability curves. Analyses performed from perspective UK's National Health Service (NHS).Twenty-eight UK NHS early pregnancy units.A cohort 711 women...