A5008586817- Assisted Reproductive Technology and Twin Pregnancy
- Uterine Myomas and Treatments
- Thyroid Disorders and Treatments
- Maternal and fetal healthcare
- Child Abuse and Related Trauma
- Reproductive Biology and Fertility
- Ectopic Pregnancy Diagnosis and Management
- Child Abuse and Trauma
- Homicide, Infanticide, and Child Abuse
- Ovarian function and disorders
- Prenatal Screening and Diagnostics
- Hernia repair and management
- Pelvic floor disorders treatments
- Gynecological conditions and treatments
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Ethics in Clinical Research
- Biomedical and Chemical Research
- Ovarian cancer diagnosis and treatment
- Preterm Birth and Chorioamnionitis
- Thyroid Cancer Diagnosis and Treatment
- Reproductive Health and Technologies
- Maternal and Perinatal Health Interventions
- Pregnancy-related medical research
- Psychotherapy Techniques and Applications
St Mary's Hospital
2020
St Mary's Hospital
2003-2019
Manchester University NHS Foundation Trust
2019
St. Mary’s Hospital
1998-2019
University of Birmingham
1998-2019
Manchester University
2019
University of Manchester
2002-2018
St. Mary's Hospital
1999-2016
University of Saint Mary
2007-2014
St. Thomas Hospital
2004
Thyroid peroxidase antibodies are associated with an increased risk of miscarriage and preterm birth, even when thyroid function is normal. Small trials indicate that the use levothyroxine could reduce incidence such adverse outcomes.We conducted a double-blind, placebo-controlled trial to investigate whether treatment would increase live-birth rates among euthyroid women who had history or infertility. A total 19,585 from 49 hospitals in United Kingdom underwent testing for function. We...
To estimate the incidence of caesarean scar pregnancy (CSP) and to describe management outcomes associated with this condition.A national cohort study using UK Early Pregnancy Surveillance Service (UKEPSS).86 participating Units.All women diagnosed in units CSP between November 2013 January 2015.Cohort identified through UKEPSS monthly mailing system.Incidence, clinical complications.102 cases were reported, an estimated 1.5 per 10 000 (95% CI 1.1-1.9) maternities. Full outcome data...
Abstract Objective To describe the prevalence of and factors associated with different thyroid dysfunction phenotypes in women who are asymptomatic preconception. Design Observational cohort study. Setting A total 49 hospitals across United Kingdom between 2011 2016. Participants Women aged 16 to 41years history miscarriage or subfertility trying for a pregnancy. Methods Prevalences 95% confidence intervals (CIs) were estimated using binomial exact method. Multivariate logistic regression...
To compare the influence on caesarean section morbidity of uterine exteriorisation or in situ repair.Randomised controlled trial.Princess Anne Maternity Unit Royal Bolton Hospital, UK.One hundred and ninety-four women undergoing delivery by section.Two intra-operative readings arterial pulse rate, mean blood pressure, haemoglobin oxygen saturation were obtained. Pre-operative day-3 concentrations determined. Intra- post-operative complications, puerperal pain scores, febrile infectious...
A 31-year-old nulliparous patient presents with a three-day history of right sided colicky abdominal pain and associated nausea. This has previously presented twice ovarian torsion the background polycystic ovaries in last two consecutive years. Blood tests were normal. Due to previous history, there was high index clinical suspicion that this may be further torsion. Therefore, taken theatre for diagnostic laparoscopy noted. At time, oophoropexy performed uterosacral ligament prevent order...
Objective To determine whether administration of exogenous human chorionic gonadotrophin (hCG) treatment improve the pregnancy outcome in first trimester threatened miscarriages. Design A prospective, double blind, randomised, placebo‐controlled trial. Setting The Early Pregnancy Assessment Unit, Royal Bolton Hospital, Bolton, United Kingdom. Population One hundred and eighty‐three women with vaginal bleeding a viable fetus seen on ultrasound scan (USS) 12 weeks pregnancy. Methods patients...
Two cases are reported of successful pregnancies following long-term semen banking prior to chemotherapy and radiotherapy for malignancy. With the first case, patient banked at age 20 years Hodgkin's disease; 11 later thawed was used IVF with intracytoplasmic sperm injection (ICSI), resulting in twins being born transfer frozen–thawed embryos. In second 17 acute myeloid leukaemia; 8 it ICSI, triplets These support men whose future fertility may be compromised by suppression spermatogenesis...
Background Thyroid autoantibodies, specifically thyroid peroxidase antibodies, have been associated with miscarriage and pre-term birth in women a normal function. Small randomised controlled trials found that treatment levothyroxine may reduce such adverse outcomes pregnancy. Objectives The AntiBodies LEvoThyroxine (TABLET) trial was conducted to explore the effects of euthyroid antibodies. A concurrent mechanistic study examine effect on immune responses. Design This randomised,...
Transvaginal evisceration of bowel has been described following vaginal, abdominal and laparoscopic hysterectomy, enterocele repair perineal proctectomy. This complication may happen anytime af...
Introduction: Multiple trials of immunotherapy for reproductive failure have failed to demonstrate significant benefit. A reason this may be the lack a test that selects which women will benefit from treatment. High density uterine naturak killer (uNK) cells has been associated with recurrent miscarriage (RM) and prednisolone was shown reduce uNK cell density. Hence we carried out double blind randomised placebo controlled trial versus in early pregnancy RM increased The aim pilot assess...
This large multicenter randomized double-blind placebo-controlled trial, in euthyroid women with thyroid peroxidase antibodies and a history of miscarriage or infertility, found no effect levothyroxine substitution from before conception to the end pregnancy on likelihood live birth.