A5013087727- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Pregnancy and preeclampsia studies
- Thyroid Disorders and Treatments
- Breastfeeding Practices and Influences
- Obesity, Physical Activity, Diet
- Thyroid Cancer Diagnosis and Treatment
- Silicon Nanostructures and Photoluminescence
- Fatty Acid Research and Health
- Assisted Reproductive Technology and Twin Pregnancy
- Per- and polyfluoroalkyl substances research
- Nanowire Synthesis and Applications
- Mobile Health and mHealth Applications
- Growth Hormone and Insulin-like Growth Factors
- Vitamin D Research Studies
- Bariatric Surgery and Outcomes
- Maternal Mental Health During Pregnancy and Postpartum
- Pregnancy and Medication Impact
- Nutrition and Health in Aging
- Body Composition Measurement Techniques
- Health, Environment, Cognitive Aging
- Neonatal Health and Biochemistry
- Reproductive System and Pregnancy
- Folate and B Vitamins Research
- Nutritional Studies and Diet
National University of Singapore
2016-2025
Singapore Institute for Clinical Sciences
2013-2025
Agency for Science, Technology and Research
2013-2025
National University Hospital
2018-2025
Hong Kong Polytechnic University
2025
National University Health System
2013-2024
Duke-NUS Medical School
2024
Harvard University Press
2024
University of California, Davis
2024
KK Women's and Children's Hospital
2024
Our aim was to study the phylogenetic relationships of all known papillomaviruses (PVs) and possibility establishing a supratype taxonomic classification based on this information. Of many detectably homologous segments present in PV genomes, 291-bp segment L1 gene is notable because it flanked by MY09 MY11 consensus primers contains highly conserved amino acid residues which simplify sequence alignment. We determined MY09-MY11 sequences human type 20 (HPV-20), HPV-21, HPV-22, HPV-23,...
Thyroid peroxidase antibodies are associated with an increased risk of miscarriage and preterm birth, even when thyroid function is normal. Small trials indicate that the use levothyroxine could reduce incidence such adverse outcomes.We conducted a double-blind, placebo-controlled trial to investigate whether treatment would increase live-birth rates among euthyroid women who had history or infertility. A total 19,585 from 49 hospitals in United Kingdom underwent testing for function. We...
New ways of detecting low concentrations analytes , which could be used as part integrated on‐chip devices, are offered by surface‐enhanced Raman‐scattering substrates fabricated on the nanoscale. The ability metal surfaces to amplify a signal (see Figure) is combined with an enlarged substrate surface area, allowing orders magnitude enhancement for detection rhodamine 6G and adenine.
OBJECTIVE SMART-GDM examined whether Habits-GDM, a smartphone application (app) coaching program, can prevent excessive gestational weight gain (EGWG) and improve glycemic control maternal neonatal outcomes in diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS In this randomized controlled trial, women diagnosed with GDM between 12 30 weeks were randomly assigned to usual care (control) or additional support from Habits-GDM that integrated dietary, physical activity, weight, glucose...
To explore the associations between type of milk feeding (the "nutrients") and mode breast "nursing") with child cognition. Healthy children from GUSTO (Growing Up in Singapore Toward healthy Outcomes) cohort participated repeated neurodevelopmental assessments 6 54 months. For "nutrients", we compared exclusively bottle-fed according to received: formula only (n = 296) vs some/all 73). "nursing", included who were fully fed milk, comparing those directly at 59) partially/completely by...
Porous silicon microcavity resonators possess the unique characteristics of line narrowing and luminescence enhancement. The emission peak position is completely tunable by changing properties central layer. Increasing thickness active layer introduces multiple narrow peaks in spectrum. Narrow visible are observed with a full width at half maximum (FWHM) value 3 nm. structure highly sensitive any slight change effective optical modifies reflectivity spectra, causing spectral shift...
Genomic variability between different viral isolates provides a powerful epidemiological tool for verifying ultrasensitive diagnostic procedures, understanding infectious pathways in individuals and human populations, studying evolution. The potential of this approach has not yet been exploited the diagnosis papillomaviruses (HPVs) like HPV type 16 (HPV-16), which are involved genital cancer. Toward end, we amplified by polymerase chain reaction, cloned, sequenced 364-bp noncoding segment...
Abstract Epidemiology has linked vitamin D deficiency with preeclampsia in humans. We hypothesized that low status pregnant mice may lead to symptoms of preeclampsia. Female BL6 were raised on D-sufficient or -deficient diets from weeks 4 age and then mated males at week 8. The resulting either allowed deliver pups monitored for blood pressure (BP) weight offspring euthanized day 14 18 gestation (E14 E18) analysis serum, placental/kidney tissues, fetuses. At E14 serum concentrations...
Improved maternal nutrition and glycaemic control before during pregnancy are thought to benefit the health of mother, with consequent benefits for infant body composition later obesity risk. Maternal insulin resistance glycaemia around conception in early may be key determinants physiology placental function, affecting fetal nutrient supply maternal-feto-placental communications throughout gestation, implications postnatal health. This double-blind randomised controlled trial will recruit...
Integrated 24-Hour Movement Guidelines provide specific recommendations on screen viewing (SV), moderate-to-vigorous physical activity (MVPA) and sleep to improve health of children youth. However, few studies have examined whether these guidelines are met in young children, particularly Asia. We evaluated adherence integrated individual its predictors 5.5-year-old Singaporean children.Growing Up Singapore towards Healthy Outcomes (GUSTO) is a mother-offspring birth cohort study. At age 5.5...
OBJECTIVE Better preconception metabolic and nutritional health are hypothesized to promote gestational normoglycemia reduce preterm birth, but evidence supporting improved outcomes with supplementation starting is limited. RESEARCH DESIGN AND METHODS This double-blind randomized controlled trial recruited from the community 1,729 U.K., Singapore, New Zealand women aged 18–38 years planning conception. We investigated whether a formulation containing myo-inositol, probiotics, multiple...
Abstract Health behaviors before, during and after pregnancy can have lasting effects on maternal infant health outcomes. Although digital interventions (DHIs) potential as a pertinent avenue to deliver mechanisms for healthy behavior change, its success is reliant addressing the user needs. Accordingly, current study aimed understand DHI needs expectations of women inform optimize future developments. Forty-four (13 pre-, 16 15 postpregnancy; age range = 21–40 years) completed 60-minute,...