Environmental factors and diet are generally believed to be accelerators of obesity hypertension, but they not the underlying cause. Our animal model hypertension is based on observation that impaired fetal growth has long-term clinical consequences induced by programming. Using undernutrition throughout pregnancy, we investigated whether effects programming adult mediated changes in insulin leptin action increased appetite may a behavioral trigger disease. Virgin Wistar rats were time mated...

An adverse prenatal environment may induce long-term metabolic consequences, in particular obesity and insulin resistance. Although the mechanisms are unclear, this programming has generally been considered an irreversible change developmental trajectory. Adult offspring of rats subjected to undernutrition during pregnancy develop obesity, hyperinsulinemia, hyperleptinemia, especially presence a high-fat diet. Reduced locomotor activity hyperphagia contribute increased fat mass. Using model...

Significant alterations in maternal nutrition may induce long-term metabolic consequences offspring, particular obesity and leptin insulin resistance. Although nutrient deprivation has been well characterized this context, there is a relative paucity of data on how high fat (HF) impacts the subsequent generation. The present study investigated effects HF either throughout mother's life up to including pregnancy lactation or restricted lactation, growth parameters male female offspring....

Developmental plasticity in response to environmental cues can take the form of polyphenism, as for discrete morphs some insects, or an apparently continuous spectrum phenotype, most mammalian traits. The metabolic phenotype adult rats, including propensity obesity, hyperinsulinemia, and hyperphagia, shows prenatal nutrition neonatal administration adipokine leptin. Here, we report that effects leptin on hepatic gene expression epigenetic status adulthood are directionally dependent animal's...

The discovery of a link between in utero experience and later metabolic cardiovascular disease is one the most important advances epidemiology research recent years. There now increasing evidence that alterations fetal environment have long-term consequences on endocrine pathophysiology adult life. This process has been termed "fetal programming," we shown undernutrition mother during gestation leads to obesity, hypertension, hyperphagia, hyperinsulinemia, hyperleptinemia offspring. Using...

The association between an adverse early life environment and increased susceptibility to later-life metabolic disorders such as obesity, type 2 diabetes cardiovascular disease is described by the developmental origins of health hypothesis. Employing a rat model maternal high fat (MHF) nutrition, we recently reported that offspring born MHF mothers are small at birth develop postnatal phenotype closely resembles human syndrome. Livers also display fatty reflecting hepatic steatosis...

While prepubertal nutritional influences appear to play a role in sexual maturation, there is need clarify the potential contributions of maternal and childhood setting tempo reproductive maturation. In present study we employed an established model programming evaluate relative prenatal postnatal nutrition on growth ovarian function female offspring.Pregnant Wistar rats were fed either calorie-restricted diet, high fat or control diet during pregnancy and/or lactation. Offspring then from...

An adverse prenatal environment may induce long-term metabolic consequences, in particular obesity, hyperleptinemia, insulin resistance, and type 2 diabetes. Although the mechanisms are unclear, this "programming" has generally been considered an irreversible change developmental trajectory. Adult offspring of rats subjected to undernutrition (UN) during pregnancy develop hyperinsulinemia, especially presence a high-fat diet. Using model maternal UN, we have recently shown that neonatal...

Maternal high-fat or high-salt diets can independently program adverse cardiometabolic outcomes in offspring. However, there is a paucity of evidence examining their effects combination on metabolic function adult Female Sprague Dawley rats were randomly assigned to either: control (CD; 10% kcal from fat, 1% NaCl), (SD; 4% (HF; 45% NaCl) and salt (HFSD; 21 days prior mating throughout pregnancy lactation. Male offspring weaned onto standard chow diet culled postnatal day 130 for plasma...

We have previously reported that offspring of mothers fed a high fat (HF) diet during pregnancy and lactation enter puberty early are hyperleptinaemic, hyperinsulinaemic obese as adults. Poor maternal care bonding can also impact development disease risk.We therefore hypothesized prenatal nutrition would affect an interaction may exist between HF care, subsequently impacting on phenotype.Wistar rats were mated randomized to control dams (CON) or from conception until the end (HF). Maternal...

Background We have shown recently that maternal undernutrition (UN) advanced female pubertal onset in a manner is dependent upon the timing of UN. The long-term consequence this accelerated puberty on ovarian function unknown. Recent findings suggest oxidative stress may be one mechanism whereby early life events impact later physiological functioning. Therefore, using an established rodent model UN at critical windows development, we examined UN-induced changes offspring and determined...

Abstract The effects of maternal fructose intake on offspring health remain largely unknown, despite the marked increase in consumption sweetened beverages that has paralleled obesity epidemic. present study investigated impact placental, fetal, and neonatal development. Female Wistar rats were time-mated allocated to receive either water [control (CONT)] or solution designed provide 20% caloric from (FR). FR was administered d 1 pregnancy until postnatal day (P) 10. All dams had ad libitum...

The global obesity pandemic is often causally linked to marked changes in diet and lifestyle, namely increases dietary intakes of high-energy diets concomitant reductions physical activity levels. However, far less attention has been paid the role developmental plasticity alterations phenotypic outcomes resulting from environmental perturbations during early-life period. Human animal studies have highlighted link between environment increased susceptibility related metabolic disorders later...

Abstract Background Fecal microbiota transplantation (FMT) is a therapeutic intervention used to treat diseases associated with the gut microbiome. In human microbiome, phages have been implicated in influencing health, successful engraftment of donor correlated FMT treatment efficacy. The impact that gastrointestinal exert on health has primarily connected their ability modulate bacterial communities gut. Nonetheless, how affects recipients’ phage populations, and turn, this influences...

Obesity and its related disorders are the most prevalent health problems in Western world. Using paradigm of fetal programming we developed a rodent model which displays phenotype obesity metabolic commonly observed human populations. We apply maternal undernutrition throughout gestation, generating nutrient-deprived intrauterine environment to induce programming. Maternal results growth retardation significantly decreased body weight at birth. Programmed offspring develop hyperphagia,...

The discovery of a link between in utero experience and later metabolic cardiovascular disease is one the most important advances epidemiology research recent years. There increasing evidence that alterations fetal environment may have long-term consequences on cardiovascular, metabolic, endocrine pathophysiology adult life. This process has been termed programming, we shown undernutrition mother during gestation leads to programming hyperphagia, obesity, hypertension, hyperinsulinemia,...