A5016277603- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Reproductive System and Pregnancy
- Prenatal Screening and Diagnostics
- Fatty Acid Research and Health
- Renal and related cancers
- IL-33, ST2, and ILC Pathways
- Endometriosis Research and Treatment
- Preterm Birth and Chorioamnionitis
- Neonatal Respiratory Health Research
- Pregnancy-related medical research
- Diet, Metabolism, and Disease
- Kruppel-like factors research
- Nitric Oxide and Endothelin Effects
- Maternal and fetal healthcare
- Epigenetics and DNA Methylation
- Receptor Mechanisms and Signaling
- Global Maternal and Child Health
- TGF-β signaling in diseases
- COVID-19 Impact on Reproduction
- Vitamin D Research Studies
- Gynecological conditions and treatments
- Cancer Risks and Factors
- Electrostatics and Colloid Interactions
Singapore Institute for Clinical Sciences
2020-2024
Agency for Science, Technology and Research
2020-2024
Shenzhen Maternity and Child Healthcare Hospital
2024
Harvard University Press
2024
University of California, Davis
2024
Guangzhou Women and Children Medical Center
2024
Guangzhou Medical University
2024
Southern Medical University
2024
Peking University Shenzhen Hospital
2024
University of Cambridge
2017-2023
A successful pregnancy depends on the intricate and timely interactions of maternal fetal cells. Placental extravillous cytotrophoblast invasion involves a cellular transition from an epithelial to mesenchymal phenotype. Villous cytotrophoblasts undergo partial (EMT) when differentiating into gain capacity migrate invade. This review summarizes our current knowledge regarding known regulators EMT in human placenta, including inducers EMT, upstream transcription factors that control...
Maternal-offspring interactions in mammals involve both cooperation and conflict. The fetus has evolved ways to manipulate maternal physiology enhance placental nutrient transfer, but the mechanisms involved remain unclear. imprinted Igf2 gene is highly expressed murine endocrine cells. Here, we show that deletion these cells impairs signaling mother, without affecting morphology. controls hormone production, including prolactins, crucial establish pregnancy-related insulin resistance...
OBJECTIVE Better preconception metabolic and nutritional health are hypothesized to promote gestational normoglycemia reduce preterm birth, but evidence supporting improved outcomes with supplementation starting is limited. RESEARCH DESIGN AND METHODS This double-blind randomized controlled trial recruited from the community 1,729 U.K., Singapore, New Zealand women aged 18–38 years planning conception. We investigated whether a formulation containing myo-inositol, probiotics, multiple...
Background Preeclampsia (PE) is a serious hypertensive pregnancy disorder with significant genetic component. Numerous studies, including our own, have yielded many susceptibility genes from distinct functional groups. Additionally, transcriptome profiling of tissues at the maternal-fetal interface has likewise differentially expressed genes. Often there little overlap between these two approaches, although identified in both approaches are significantly associated PE. We thus taken novel...
Fetal growth restriction (FGR) is commonly associated with placental insufficiency and inflammation. Nonetheless, the role played by inflammasomes in pathogenesis of FGR poorly understood. We hypothesised that are differentially expressed contribute to aberrant trophoblast function. Inflammasome gene expression profiles were characterised real-time PCR on human tissues collected from third trimester gestation-matched control pregnancies (n = 25/group). The functional significance a candidate...
Abnormal trophoblast function is associated with fetal growth restriction (FGR). The JAK-STAT pathway one of the principal signalling mechanisms by which cytokines and factors modulate cell proliferation, differentiation, migration apoptosis. expression placental genes in human idiopathic FGR unknown. In this study, we propose hypothesis that are differentially expressed FGR-affected pregnancies contribute to abnormal feto-placental modulating amino acid transporter SNAT2, differentiation...
Fetal growth restriction (FGR) is a leading cause of perinatal morbidity and mortality. Altered placental formation functional capacity are major contributors to FGR pathogenesis. Relating structure function across the placenta in healthy pregnancies remains largely unexplored but could improve understanding diseases. We investigated integration these parameters spatially term human using predictive modelling. Systematic sampling was able overcome heterogeneity morphological molecular...
Abstract Pathological placental inflammation increases the risk for several adult disorders, but these mediators are also expressed under homeostatic conditions, where their contribution to health outcomes is unknown. Here we define an inflammation-related expression signature, primarily in Hofbauer cells of term placenta and use quantitative trait loci create a polygenic score (PGS) predictive its expression. Using this PGS UK Biobank conduct phenome-wide association study, followed by...
Homeobox genes regulate embryonic and placental development, are widely expressed in the human placenta, but their regulatory control by DNA methylation is unclear. analysis was performed on placentae from first, second third trimesters to determine patterns of homeobox gene promoters across gestation. Most were hypo-methylated throughout gestation, suggesting that not primary mechanism involved regulating HOX expression placenta. Nevertheless, several showed variable with a general trend...
Vitamin D-binding protein is a multifunctional serum with multiple actions related to normal health. transports vitamin D and influences the metabolism of this key hormone but it also has additional immunomodulatory actin-clearing properties. We investigated whether expression altered in fetal growth restriction-associated placental dysfunction. Protein was extracted from 35 placentae derived 17 healthy control subjects 18 gestation-matched restriction (FGR). FGR were further subdivided as...
Fetal growth restriction (FGR) is caused by poor placental development and function early in gestation. It well known that placentas from women with FGR exhibit reduced cell growth, elevated levels of apoptosis perturbed expression the factors, cytokines homeobox gene family transcription factors. Previous studies have reported insulin-like factor-2 (IGF2) interacts its receptor-2 (IGF2R) to regulate villous trophoblast survival apoptosis. In this study, we hypothesized human IGF2R-mediated...