A5078517652- Inhalation and Respiratory Drug Delivery
- Asthma and respiratory diseases
- Neonatal Respiratory Health Research
- Pediatric health and respiratory diseases
- RNA Interference and Gene Delivery
- Drug Solubulity and Delivery Systems
- Pregnancy and preeclampsia studies
- Antimicrobial Peptides and Activities
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Immune Response and Inflammation
- Advanced Drug Delivery Systems
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Toxin Mechanisms and Immunotoxins
- RNA modifications and cancer
- Pregnancy-related medical research
- Microbial Metabolic Engineering and Bioproduction
- DNA and Nucleic Acid Chemistry
- Birth, Development, and Health
- Atomic and Subatomic Physics Research
- Circadian rhythm and melatonin
- Berberine and alkaloids research
- Pleural and Pulmonary Diseases
- Electromagnetic Fields and Biological Effects
- NF-κB Signaling Pathways
University of Manchester
2022-2025
Monash University
2017-2024
Australian Regenerative Medicine Institute
2019-2024
Amity University
2014-2024
Centre for Immunity, Infection and Evolution
2023
University of Calcutta
2022
Clayton Foundation
2019
Czech Academy of Sciences, Institute of Biotechnology
2015
Amity University
2015
Noida International University
2015
This review delves into the pivotal role of long non-coding RNA NEAT1 in cancer biology, particularly lung (LC). It emphasizes NEAT1's unique subcellular localization and active involvement gene regulation chromatin remodeling. The highlights impact on LC development progression, including cell processes such as proliferation, migration, invasion, resistance to therapy, positioning it a potential diagnostic marker therapeutic target. complex web regulatory interactions with proteins...
Fetal growth restriction (FGR) is commonly associated with placental insufficiency and inflammation. Nonetheless, the role played by inflammasomes in pathogenesis of FGR poorly understood. We hypothesised that are differentially expressed contribute to aberrant trophoblast function. Inflammasome gene expression profiles were characterised real-time PCR on human tissues collected from third trimester gestation-matched control pregnancies (n = 25/group). The functional significance a candidate...
Chronic inflammation, oxidative stress, and airway remodelling represent the principal pathophysiological features of chronic respiratory disorders. Inflammation stimuli like lipopolysaccharide (LPS) activate macrophages dendritic cells, with concomitant M1 polarization release pro-inflammatory cytokines. inflammation stress lead to causing irreversible functional structural alterations lungs. Airway is multifactorial, however, hormone transforming growth factor-β (TGF-β) one main...
Idiopathic pulmonary fibrosis (IPF) is characterised by lung scarring and stiffening, for which there no effective cure. Based on the immunomodulatory anti-fibrotic effects of induced pluripotent stem cell (iPSC) mesenchymoangioblast-derived mesenchymal cells (iPSCs-MSCs), this study evaluated therapeutic iPSCs-MSCs in a bleomycin (BLM)-induced model fibrosis. Adult male C57BL/6 mice received double administration BLM (0.15 mg/day) 7-days apart were then maintained further 28-days (until...
Carbon nanosheets with sharp “knife-like” edges interact an <italic>E. coli</italic> bacterial membrane resulting in cell death.
Despite developments in pulmonary radiotherapy, radiation-induced lung toxicity remains a problem. More sensitive imaging able to increase the accuracy of diagnosis and radiotherapy may help reduce this Super-paramagnetic iron oxide nanoparticles are used imaging, but without further modification can cause unwanted inflammation. Complex carbohydrate polymer-based coatings have been used, simpler compounds provide additional benefits. Herein, we designed generated super-paramagnetic coated...
We described a novel synthetic peptide in which glutamine residue binds through hydrogen bonding to guanine-base and trytophan intercalates with K+ resulting stabilization of human telomeric G-quadruplex high selectivity over its complementary c-rich strand double-stranded DNA C-rich strand. This offers great potential for cancer treatment by inhibiting the telomere extension telomerase.
Fibrosis, a hallmark of chronic kidney disease (CKD), impairs the viability human bone marrow derived-mesenchymal stromal cells (BM-MSCs) post-transplantation. To address this, we demonstrated that combining BM-MSCs with anti-fibrotic drug, serelaxin (RLX), enhanced BM-MSC-induced renoprotection in preclinical CKD models. Given increased interest and manufacturing advantages to using stem cell-derived exosomes (EXO) as therapeutics, this study determined whether RLX could enhance therapeutic...
Research in recent decades has revealed that the guanine (G)-quadruplex secondary structure DNA modulates a variety of cellular events are mostly related to serious diseases. Systems capable regulating G-quadruplex structures would therefore be useful for modulation various produce biological effects. A high specificity recognition telomeric been observed BLM helicase. We identified peptides from HRDC domain using molecular docking approach with available solutions and crystal human...
Rationale Asthma is a rhythmic inflammatory disease of the airway, regulated by circadian clock. “Spill-over” airway inflammation into systemic circulation occurs in asthma and reflected circulating immune cell repertoire. The objective present study was to determine how impacts peripheral blood diurnal rhythmicity. Methods 10 healthy mild/moderate participants were recruited an overnight study. Blood drawn every 6 h for 24 h. Main results molecular clock cells altered; PER3 significantly...
Nicotine is a parasympathomimetic alkaloid found in the nightshade family of plants (Solanaceae) and cholinergic drug. It acts directly by stimulating nicotinic or muscarinic receptors indirectly inhibiting cholinesterase, promoting acetylcholine release, other mechanisms. 3% tobacco one cigarette yields 1 mg nicotine. As nicotine enters body, it disturbs healthy functioning body. In this study, we isolated UMNSAH/DF-1 cell line from Gallus gallus. For this, 9 ± 2 day old chicken embryo was...