A5040670526- Pregnancy and preeclampsia studies
- Reproductive System and Pregnancy
- Birth, Development, and Health
- Maternal and fetal healthcare
- Endometriosis Research and Treatment
- Nitric Oxide and Endothelin Effects
- Neonatal Respiratory Health Research
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Angiogenesis and VEGF in Cancer
- Blood Coagulation and Thrombosis Mechanisms
- Cell Adhesion Molecules Research
- Pregnancy and Medication Impact
- Physiological and biochemical adaptations
- Cancer, Hypoxia, and Metabolism
- Congenital heart defects research
- Organ Transplantation Techniques and Outcomes
- Eicosanoids and Hypertension Pharmacology
- Preterm Birth and Chorioamnionitis
- Congenital Diaphragmatic Hernia Studies
- Ovarian function and disorders
- Liver Disease Diagnosis and Treatment
- TGF-β signaling in diseases
- Prenatal Screening and Diagnostics
- Reproductive Physiology in Livestock
St George's, University of London
2013-2025
Genomics (United Kingdom)
2025
National Institutes of Health
2020
Yale University
2020
Harvard University
2020
Rockefeller University
2020
Brigham and Women's Hospital
2020
Federation of American Societies for Experimental Biology
2020
Max Delbrück Center
2010-2017
University of London
2004-2016
Progesterone is indispensable for differentiation of human endometrial stromal cells (HESCs) into decidual cells, a process that critically controls embryo implantation. We now show an important role androgen receptor (AR) signaling in this process. Decreased posttranslational modification the AR by small ubiquitin-like modifier (SUMO)-1 decidualizing accounted increased responsiveness to androgen. By combining interfering RNA technology with genome-wide expression profiling, we found and...
Abstract During human pregnancy, natural killer (NK) cells accumulate in the maternal decidua, but their specific roles remain to be determined. Decidual NK (dNK) are present during trophoblast invasion and uterine spiral artery remodelling. These events crucial for successful placentation provision of an adequate blood supply developing fetus. Remodelling arteries is impaired dangerous pregnancy complication pre‐eclampsia. We studied dNK isolated from pregnancies at 9–14 weeks' gestation,...
Objective— Invasion of uterine spiral arteries by extravillous trophoblasts in the first trimester pregnancy results loss endothelial and musculoelastic layers. This remodeling is crucial for an adequate blood supply to fetus with a failure remodel implicated etiology hypertensive disorder preeclampsia. The mechanism which induce this key process unknown. study gives insights into potential mechanisms involved. Methods Results— Spiral were dissected from nonplacental bed biopsies obtained at...
The expression of hepatocyte growth factor (HGF) is essential for normal placental development although its function unknown. In this study we examined the effect HGF on trophoblast cell motility and invasion fibrin gels investigated possible role nitric oxide (NO) in process. human extravillous line SGHPL‐4 express both constitutive inducible isoforms synthase (NOS). significantly stimulates monolayer culture, production guanosine 3′:5′‐cyclic monophosphate (cyclic GMP). Invasion, cyclic...
Remodeling of the uterine spiral arteries during pregnancy transforms them from high to low resistance vessels that lack vasoconstrictive properties. This process is essential meet demand for increased blood flow imposed by growing fetus. Loss endothelial and smooth muscle cells (SMC) evident in remodeled but mechanisms underlying this transformation remain unknown. study investigated hypothesis fetal trophoblast invading placenta instigate remodeling triggering cell death vascular SMC....
During the first trimester of pregnancy, uterine spiral arteries are remodeled, creating heavily dilated conduits that lack maternal vasomotor control but allow placenta to meet an increasing requirement for nutrients and oxygen. To effect permanent vasodilatation, internal elastic lamina medial elastin fibers must be degraded. In this study, we sought identify elastolytic proteases involved in process. Primary first-trimester cytotrophoblasts (CTBs) derived from exhibited intracellular...
Transformation of the uterine spiral arteries (SAs) during pregnancy is critical to support developing fetus, and impaired in some disorders, including preeclampsia. Decidual natural killer (dNK) cells play a role SA remodeling, although their interactions with fetal trophoblast remain unclear. A artery Doppler resistance index (RI) first trimester can be used as proxy measure extent remodeling; we have this technique characterize dNK from pregnancies normal (normal RI) (high which display...
Progressive tumour growth is dependent on the development of a functional vasculature and highly regulated by factors cytokines. Nitric oxide (NO) free radical, produced both host cells, functions as signalling molecule downstream several angiogenic factors. Both pro- antitumourigenic properties have been attributed to NO. The expression inducible isoform NO synthase (iNOS) was knocked down in C6 glioma cell line using constitutive antisense RNA, effect tumour-derived progression...
During pregnancy, a specialized type of NK cell accumulates in the lining uterus (decidua) and interacts with semiallogeneic fetal trophoblast cells. dNK cells are functionally phenotypically distinct from PB implicated regulation transformation uterine spiral arteries, which if inadequately performed, can result pregnancy disorders. Here, we have used artery Doppler RI first trimester as proxy measure extent arteries to identify pregnancies high RI, indicative impaired remodeling. We flow...
Preeclampsia is a complex and common human-specific pregnancy syndrome associated with placental pathology. The human specificity provides both intellectual methodological challenges, lacking robust model system. Given the role of imprinted genes in placentation vulnerability to loss imprinting changes, there has been extensive speculation, but no evidence, that are involved preeclampsia. Our study aims investigate whether disturbed contributes preeclampsia.We first aimed confirm...
Pre-eclampsia is a leading cause of maternal mortality and morbidity that involves pregnancy-related stressors on the cardiovascular metabolic systems. As nutrition important to support optimal development placenta for developing fetus, diets may play role in preventing pre-eclampsia. The purpose this scoping review map nutritional deficiencies imbalances associated with pre-eclampsia incidence discuss evidence consistency linkages current understandings etiology
Experimental evidence suggests that estrogens stimulate the production of nitric oxide (NO) by vascular endothelial cells. This effect has been attributed to increased expression and enzymatic activity both constitutive inducible isoforms NO synthase. In this study, we have investigated whether regulate metabolism or release asymmetric dimethylarginine (ADMA), an endogenous inhibitor synthase.The concentration ADMA in plasma 15 postmenopausal women was 0.722+/-0.04 micromol/L (mean+/-SEM)....
Rats harboring the human angiotensinogen and renin genes develop preeclamptic features in pregnancy. The rats exhibit a deeper trophoblast invasion associated with reduced resistance index by uterine Doppler. Doxycycline inhibits matrix metalloproteinase activity. We tested hypothesis that inhibition reduces subsequent changes placental perfusion. Preeclamptic pregnant control Sprague-Dawley were treated doxycycline (30 mg/kg of body weight orally) from gestational day 12 until 18. Placental...