A5101862771- Cell Adhesion Molecules Research
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pregnancy and preeclampsia studies
- S100 Proteins and Annexins
- Birth, Development, and Health
- Cellular Mechanics and Interactions
- Phagocytosis and Immune Regulation
- Erythrocyte Function and Pathophysiology
- Extracellular vesicles in disease
- Intestinal and Peritoneal Adhesions
- Receptor Mechanisms and Signaling
- Protein Kinase Regulation and GTPase Signaling
- Congenital Diaphragmatic Hernia Studies
- Congenital Anomalies and Fetal Surgery
- Platelet Disorders and Treatments
- Maternal and fetal healthcare
- Renal and related cancers
- Protease and Inhibitor Mechanisms
- Blood properties and coagulation
- Pulmonary Hypertension Research and Treatments
- Diabetes and associated disorders
- Immune Response and Inflammation
- Advanced Glycation End Products research
The University of Melbourne
2016-2024
King's College London
2015-2021
University of Cambridge
2018-2020
Royal Women's Hospital
2016
British Heart Foundation
2015
University of Cape Town
2003
A successful pregnancy depends on the intricate and timely interactions of maternal fetal cells. Placental extravillous cytotrophoblast invasion involves a cellular transition from an epithelial to mesenchymal phenotype. Villous cytotrophoblasts undergo partial (EMT) when differentiating into gain capacity migrate invade. This review summarizes our current knowledge regarding known regulators EMT in human placenta, including inducers EMT, upstream transcription factors that control...
L-selectin is a cell adhesion molecule that tethers free-flowing leukocytes from the blood to luminal vessel walls, facilitating initial stages of their emigration circulation toward an extravascular inflammatory insult. Following shear-resistant wall, has frequently been reported be rapidly cleaved plasma membrane (known as ectodomain shedding), with little knowledge timing or functional consequence this event. Using advanced imaging techniques, we observe shedding occurring exclusively...
ABSTRACT The migration of circulating neutrophils towards damaged or infected tissue is absolutely critical to the inflammatory response. L-selectin a cell adhesion molecule abundantly expressed on neutrophils. For over two decades, neutrophil has been assigned exclusive role supporting tethering and rolling – initial stages multi-step cascade. Here, we provide direct evidence for contributing transendothelial (TEM). We show that co-clusters with PECAM-1 well-characterised involved in...
The endothelium is an attractive drug target and important site of adverse reactions. Endothelial dysfunction strongly associated with inflammation contributes to drug-induced cardiovascular toxicity. cells in the circulation are exposed haemodynamic forces including shear stress. Including stress may improve future endothelial cell discovery or toxicity screening. Piezo-1 required for respond In this study, we investigated whether a small molecule activator Piezo-1, Yoda-1, can mimic effect...
Abstract Activated, procoagulant platelets shed phosphatidylserine (PS)-exposing extracellular vesicles (EVs) from their surface in a Ca 2+ - and calpain-dependent manner. These PS-exposing EVs are prothrombotic proinflammatory found at elevated levels many cardiovascular metabolic diseases. How is not fully understood. A clearer understanding of this process may aid the development drugs to selectively block release. In study we report that 2-aminoethoxydiphenylborate (2-APB) significantly...
HMGB1 and HMGB2 are DNA-interacting proteins but can also have extracellular actions during inflammation. Despite their relatively high homology, they may distinct roles, making it essential to be able differentiate between the two. Here we examine specificity of five commercially-available anti-HMGB1 antibodies. By Western blotting recombinant HMGB1−/− mouse embryonic fibroblasts, identified only one antibody that, under our experimental conditions, did not detect HMGB2. Selecting specific...