Krys Baker
A5017705632- Cancer Risks and Factors
- Thyroid Disorders and Treatments
- BRCA gene mutations in cancer
- Global Cancer Incidence and Screening
- Thyroid Cancer Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Homicide, Infanticide, and Child Abuse
- Palliative Care and End-of-Life Issues
- Childhood Cancer Survivors' Quality of Life
- Total Knee Arthroplasty Outcomes
- Obesity, Physical Activity, Diet
- Inflammatory Bowel Disease
- Metabolism, Diabetes, and Cancer
- Microscopic Colitis
- Obesity and Health Practices
- Rheumatoid Arthritis Research and Therapies
- Vitamin D Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Health and Mental Health
- Cervical Cancer and HPV Research
- Genetic Associations and Epidemiology
- Blood Pressure and Hypertension Studies
- Prenatal Screening and Diagnostics
- Endometrial and Cervical Cancer Treatments
- Colorectal Cancer Screening and Detection
Fred Hutch Cancer Center
2024
University of Oxford
1989-2019
University of Birmingham
2019
Coventry (United Kingdom)
2018
North Yorkshire County Council
2017
West Suffolk College
2017
University of Otago
2017
General Department of Preventive Medicine
2017
Lancet Laboratories
2010
Weatherford College
2010
Thyroid peroxidase antibodies are associated with an increased risk of miscarriage and preterm birth, even when thyroid function is normal. Small trials indicate that the use levothyroxine could reduce incidence such adverse outcomes.We conducted a double-blind, placebo-controlled trial to investigate whether treatment would increase live-birth rates among euthyroid women who had history or infertility. A total 19,585 from 49 hospitals in United Kingdom underwent testing for function. We...
There is limited evidence on how the risk of breast cancer and its subtypes depend low-penetrance susceptibility loci, individually or in combination.To analyze risk, overall by tumor subtype, relation to 14 individual single-nucleotide polymorphisms (SNPs) previously linked disease, a polygenic score.Study 10,306 women with (mean age at diagnosis, 58 years) 10,393 without who 2005-2008 provided blood samples for genotyping large prospective study UK women; meta-analysis these results other...
Some investigators have reported an excess risk of venous thromboembolism (VTE) associated with depression and use antidepressant drugs. We explored these associations in a large prospective study UK women.
Abstract Background Most previous studies of rheumatoid arthritis (RA) and cancer risk have lacked information on potential confounding factors. We investigated RA-associated risks in a large cohort women the UK, taking account shared Methods In 1996–2001, aged 50–64, who were invited for routine breast screening at 66 National Health Service (NHS) centres England Scotland, also to take part Million Women Study. Participants provided sociodemographic, lifestyle health-related factors,...
Excess weight is associated with poor health and increased health-care costs. However, a detailed understanding of the effects excess on total hospital costs for different conditions needed.
SUMMARY A pilot study was performed to assess the role of cyclosporin in management severe inflammatory bowel disease. Twelve patients with Crohn's disease and 12 ulcerative colitis were admitted hospital a attack. They treated an intravenous regimen corticosteroids for 5 days followed by oral therapy. In addition, they received 6‐week course cyclosporin, initially 15 mg kg −1 day reduced 7.5 . comparison historical controls, addition standard corticosteroid therapy appeared have no benefit....
Abstract Background The strong association of body mass index (BMI) with increased oesophageal adenocarcinoma risk is established, but its relationship squamous cell carcinoma less clear. There little evidence regarding the abdominal adiposity either subtype. Methods In a large prospective cohort women in UK, mean age 56.2 [standard deviation (SD) = 4.9] years, we investigated and relation to self-reported BMI, waist circumference (WC) waist-hip ratio (WHR), using Cox regression estimate...
Setting: The Million Women Study is a cohort study of women aged 50–64 years in England and Scotland. As component the follow-up questionnaire, participants were asked to indicate if they had an abnormal cervical smear previous five years. This compared self-reported abnormalities with screening records obtained from National Health Service Cervical Screening Programme. Methods: For 1944 randomly selected Oxfordshire, assessed over six-year period prior date self-reporting. was chosen allow...
Background Thyroid autoantibodies, specifically thyroid peroxidase antibodies, have been associated with miscarriage and pre-term birth in women a normal function. Small randomised controlled trials found that treatment levothyroxine may reduce such adverse outcomes pregnancy. Objectives The AntiBodies LEvoThyroxine (TABLET) trial was conducted to explore the effects of euthyroid antibodies. A concurrent mechanistic study examine effect on immune responses. Design This randomised,...
This large multicenter randomized double-blind placebo-controlled trial, in euthyroid women with thyroid peroxidase antibodies and a history of miscarriage or infertility, found no effect levothyroxine substitution from before conception to the end pregnancy on likelihood live birth.
Both genetic and environmental factors contribute to the risk of breast cancer but it is unclear whether specific gene-environment interactions increase risk. Genome-wide association studies identified a number low-penetrance susceptibility polymorphisms. There are scant data on combined effects these polymorphisms incidence cancer. Some suggested possible between some use hormone replacement therapy (HRT) or cancer, were inconsistent. The aim this prospective cohort study was determine...
BACKGROUND Thyroid peroxidase antibodies are associated with increased risk of miscarriage and preterm birth, even when thyroid function is normal. Small trials indicate levothyroxine could reduce such adverse outcomes. METHODS We conducted a double-blind, placebo-controlled trial to investigate whether treatment would increase live birth rates among euthyroid women history or infertility. randomly assigned receive 50mcg daily placebo, commenced preconception continued until the end...