A5037261045- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Breast Cancer Treatment Studies
- Colorectal Cancer Screening and Detection
- Economic and Financial Impacts of Cancer
- COVID-19 and healthcare impacts
- Venous Thromboembolism Diagnosis and Management
- Estrogen and related hormone effects
- Nutritional Studies and Diet
- Ovarian cancer diagnosis and treatment
- Breast Implant and Reconstruction
- Cancer Diagnosis and Treatment
- Biomedical Text Mining and Ontologies
- Genetic factors in colorectal cancer
- Menopause: Health Impacts and Treatments
- Women's cancer prevention and management
- BRCA gene mutations in cancer
- Cancer survivorship and care
- Pancreatic and Hepatic Oncology Research
- Nutrition, Genetics, and Disease
- Surgical Sutures and Adhesives
- Advances in Oncology and Radiotherapy
- School Health and Nursing Education
- Antiplatelet Therapy and Cardiovascular Diseases
- Mental Health and Patient Involvement
University of Oxford
2016-2025
Oxford University Hospitals NHS Trust
2013-2025
Nuffield Health
2021
Oxford Health NHS Foundation Trust
2021
General Department of Preventive Medicine
2017
North Yorkshire County Council
2017
University of Otago
2017
West Suffolk College
2017
Churchill Hospital
2017
GlaxoSmithKline (United Kingdom)
2016
Breast cancer is now the most commonly diagnosed in world. The recent global burden figures estimate that there were 2.26 million incident breast cases 2020 and disease leading cause of mortality women worldwide. incidence strongly correlated with human development, a large rise anticipated regions world are currently undergoing economic transformation. Survival, however, far less favourable developed regions. There multitude factors behind disparities survival rates, including delays...
Abstract Delays in cancer diagnosis and treatment due to the COVID-19 pandemic is a widespread source of concern, but scale challenge for different tumour sites not known. Routinely collected NHS England Cancer Waiting Time data were analysed compare activity breast first 6 months 2020 compared same time period 2019. The number referrals suspected was 28% lower ( N = 231,765 versus 322,994), patients who received their 16% 19,965 23,881). These suggest that cancers diagnosed during half as...
In the United Kingdom, breast cancer incidence is lower in South Asian and Black women than White women, but extent to which this due known risk factors unknown. a large prospective study, we describe by ethnicity, before after adjustment for disease. Women were recruited into Million Study 1996–2001, when information on reproductive lifestyle influence of was obtained. Ethnicity determined from study questionnaires hospital admission data. Cox regression models used calculate adjusted...
Some investigators have reported an excess risk of venous thromboembolism (VTE) associated with depression and use antidepressant drugs. We explored these associations in a large prospective study UK women.
:IntroductionPrevious studies have reported an overall lower breast cancer incidence in women from Asian and Black backgrounds compared with white women. Age standardised age specific rates the largest ethnicities within groups are not reported.Materials methodsData on population size distribution of five ethnic interest (white British, African, Caribbean, Indian Pakistani) were extracted Office for National Statistics 2001, 2011 2021 census data England.Cancer registrations invasive (ICD-10...
Breast cancer (BC) is a heterogeneous disease with subtypes based on receptor status (estrogen [ER], progesterone [PR], and human epidermal growth factor 2 [HER2]), influencing prognosis treatment. A higher socioeconomic position (SEP) associated an increased BC risk, but its relation to less clear. This study analyzed 311,631 women from the EPIC cohort, focusing incidence of in situ invasive (overall by subtype). Educational attainment was used as proxy for SEP, hazard ratios (HRs) were...
Associations between behavioural and other personal factors colorectal cancer risk have been reported to vary by tumour characteristics, but evidence is inconsistent. In a large UK-based prospective study we examined associations of 14 postulated with overall, across three anatomical sites four morphological subtypes. Among 1.3 million women, 18,518 incident cancers were identified during 13.8 (SD 3.4) years follow-up via record linkage national registry data. Cox regression yielded adjusted...
There is limited information about participation in organised population-wide screening programmes by people with disabilities.
Abstract Background Ethnic minority women are commonly reported to have more aggressive breast cancer than White women, but there is little contemporary national evidence available. Methods We analysed data from the National Cancer Registration and Analysis Service on diagnosed with invasive during 2013–2018. Multivariable logistic regression yielded adjusted odds ratios (and 95% confidence intervals) of less favourable tumour characteristics (high stage, high grade, ER negative, Her2...
Abstract Background Most previous studies of rheumatoid arthritis (RA) and cancer risk have lacked information on potential confounding factors. We investigated RA-associated risks in a large cohort women the UK, taking account shared Methods In 1996–2001, aged 50–64, who were invited for routine breast screening at 66 National Health Service (NHS) centres England Scotland, also to take part Million Women Study. Participants provided sociodemographic, lifestyle health-related factors,...
Excess weight is associated with poor health and increased health-care costs. However, a detailed understanding of the effects excess on total hospital costs for different conditions needed.
Cancer services were seriously disrupted during the COVID-19 pandemic. Using publicly available data for England, we show that breast cancer diagnoses decreased substantially in first year of pandemic, but have recovered to at least pre-pandemic levels. Long term follow-up is needed assess impact on outcomes.
The lower incidence of breast cancer in Asian populations where the intake animal products is than that Western has led some to suggest a vegetarian diet might reduce risk. Between 2011 and 2014 we conducted multicentre hospital based case—control study eight centres India. Eligible cases were women aged 30–70 years, with newly diagnosed invasive (ICD10 C50). Controls frequency matched by age region residence chosen from accompanying attendants patients or those general without cancer....
Outcomes from breast cancer for women in the UK have improved significantly over recent decades. These gains are largely attributable to a combination of earlier diagnosis and access treatments delivered patients by National Health Service irrespective cost. Ethnic minority groups make up almost fifteen percent population there is concern however that these may poorer outcomes disease. In this short report we seek summarise what current evidence tells us about patterns incidence ethnic order...
Limited information is available about patterns of surgical management early breast cancer by ethnicity women in England, and any potential inequalities the treatment received for cancer.National Cancer Registration Analysis Service data diagnosed with invasive (ICD-10 C50) during 2012-2017 were analysed. Multivariable logistic regression was used to estimate odds ratios (ORs) 95 per cent confidence intervals risk mastectomy versus breast-conserving surgery (black African, black Caribbean,...
Abstract Background The strong association of body mass index (BMI) with increased oesophageal adenocarcinoma risk is established, but its relationship squamous cell carcinoma less clear. There little evidence regarding the abdominal adiposity either subtype. Methods In a large prospective cohort women in UK, mean age 56.2 [standard deviation (SD) = 4.9] years, we investigated and relation to self-reported BMI, waist circumference (WC) waist-hip ratio (WHR), using Cox regression estimate...
Abstract The associations of certain factors, such as age and menopausal hormone therapy, with breast cancer risk are known to differ for interval screen‐detected cancers. However, the extent which other established factors by mode detection is unclear. We investigated a wide range using data from large UK cohort linkage National Health Service Breast Screening Programme, registration, health records. used Cox regression estimate adjusted relative risks (RRs) 95% confidence intervals (CIs)...
David Dodwell and colleagues examine why treatment variation continues to occur in breast cancer despite high quality evidence on best practice