A5051169402- Congenital gastrointestinal and neural anomalies
- Gastrointestinal motility and disorders
- Intestinal Malrotation and Obstruction Disorders
- Neuropeptides and Animal Physiology
- Infant Health and Development
- Digestive system and related health
- Nitric Oxide and Endothelin Effects
- Retinal Development and Disorders
- Neuroscience and Neuropharmacology Research
- Photoreceptor and optogenetics research
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Congenital Anomalies and Fetal Surgery
- Congenital heart defects research
- Receptor Mechanisms and Signaling
- Axon Guidance and Neuronal Signaling
- Neurogenesis and neuroplasticity mechanisms
- Neuroendocrine regulation and behavior
- Congenital Diaphragmatic Hernia Studies
- Gastroesophageal reflux and treatments
- Diet and metabolism studies
- Atomic and Subatomic Physics Research
- Neuroscience of respiration and sleep
- Nerve injury and regeneration
- Anesthesia and Neurotoxicity Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
Institute for Gerontological Research
2024
The University of Melbourne
2011-2022
Mayo Clinic Hospital
2022
Western University
2017-2021
North Yorkshire County Council
2017
University of Otago
2017
West Suffolk College
2017
General Department of Preventive Medicine
2017
University of Oxford
2017
Robarts Clinical Trials
2017
Abstract Enteric neurons and glia arise from the neural crest. The phenotype of crest‐derived cells was examined as they differentiated into or in mouse small large intestine. Previous studies have shown that undifferentiated enteric crest–derived are Phox2b + /Ret /p75 /Sox10 , at embryonic day (E) 10.5, about 10–15% intestine started to differentiate neurons. In current study, by E12.5 E14.5, 25% 47%, respectively, were immunoreactive pan‐neuronal protein, ubitquitin hydrolase (PGP9.5),...
Cell therapy has the potential to treat gastrointestinal motility disorders caused by diseases of enteric nervous system. Many studies have demonstrated that various stem/progenitor cells can give rise functional neurons in embryonic gut; however, it is not yet known whether transplanted neural progenitor migrate, proliferate, and generate postnatal bowel vivo. We neurospheres generated from fetal intestinal crest–derived into colon mice. The neurosphere-derived migrated, proliferated, glial...
Cells of the enteric nervous system are derived from neural crest. Probes to a number molecules identify crest-derived cells within gastrointestinal tract embryonic mice prior their differentiation into neurons and glial cells. However, it is unclear whether different markers identifying all In this study distribution p75NTR-immunoreactivity was compared with that Ret-, Phox2a-, Phox2b-, tyrosine hydroxylase (TH) in undifferentiated E10.5–E13.5 mouse intestine. Neural colonise gut...
Tachykinins, including substance P, neurokinin A, and neuropeptides K γ, are expressed widely in the peripheral nervous system where they affect smooth muscle contraction, exocrine gland secretion, vascular permeability, neurotransmission. Substance preferred ligand for NK1 receptor, is found high concentrations enteric system. In present study, localisation distribution of receptor was studied throughout gastrointestinal tract guinea-pig by using a polyclonal antiserum raised against...
The recent availability of antisera to the vesicular acetylcholine transporter (VAChT) and choline acetyltransferase (ChAT) that demonstrate peripheral cholinergic neurons has made possible anatomical identification in enteric nervous system. In this study, we localised mouse small large intestine identified which substances are found colocalised neurons.Immunohistochemical single double staining techniques were used on whole mount preparations frozen sections examine localisation chemical...