A5074786116- Global Cancer Incidence and Screening
- Cancer Risks and Factors
- Colorectal Cancer Screening and Detection
- Nutritional Studies and Diet
- Health disparities and outcomes
- Cervical Cancer and HPV Research
- Prenatal Screening and Diagnostics
- Ovarian cancer diagnosis and treatment
- Nutrition, Genetics, and Disease
- Endometrial and Cervical Cancer Treatments
- Acute Lymphoblastic Leukemia research
- Breast Cancer Treatment Studies
- Parvovirus B19 Infection Studies
- Genomic variations and chromosomal abnormalities
- Obesity, Physical Activity, Diet
- Global Health Care Issues
- Congenital Heart Disease Studies
- Lymphoma Diagnosis and Treatment
- Cardiac Health and Mental Health
- Genital Health and Disease
- Healthcare Decision-Making and Restraints
- Thyroid Cancer Diagnosis and Treatment
- Criminal Justice and Corrections Analysis
- Chemical Safety and Risk Management
- BRCA gene mutations in cancer
University of Oxford
2015-2025
Tsinghua University
2024
Royal Hobart Hospital
2021
Institut Català de la Salut
2019
North Yorkshire County Council
2017
University of Otago
2017
General Department of Preventive Medicine
2017
West Suffolk College
2017
John Radcliffe Hospital
2017
Campden BRI (United Kingdom)
2017
Abstract Uncertainty remains regarding the role of diet in colorectal cancer development. We examined associations 97 dietary factors with risk 542,778 Million Women Study participants (12,251 incident cases over 16.6 years), and conducted a targeted genetic analysis ColoRectal Transdisciplinary Study, Colon Cancer Family Registry, Genetics Epidemiology Colorectal Consortium (GECCO). Alcohol (relative per 20 g/day=1.15, 95% confidence interval 1.09-1.20) calcium (per 300 mg/day=0.83,...
BackgroundSocial isolation has been associated with increased risk of coronary heart disease and stroke. However, it is unclear whether the associations differ between fatal non-fatal events or by type (living alone having few social contacts). We aimed to examine these in two large UK prospective cohorts.MethodsMillion Women Study Biobank participants without previous stroke who provided data median year 2010 (IQR 2009–2011) on contacts were included this analysis. Participants followed up...
Ovarian cancer is the fifth leading cause of mortality in UK women. survival varies by disease stage at diagnosis, but evidence mixed on effect tumour histological type (histotype) and other factors. 1.3 million women completed a detailed health questionnaire 1996–2001 were followed for incident cancers deaths via linkage to national databases. Using Cox regression models, we estimated adjusted relative risks (RRs) death from ovarian cancer, histotype, 16 personal characteristics During 17.7...
Amiodarone is widely used in adults with congenital heart disease, but no systematic study has been published on its effects thyroid function these patients. A retrospective was performed to examine the frequency of amiodarone-associated dysfunction disease and identify any contributing factors.All (16 60 years old) were identified from a database if they had preexisting taken amiodarone for >/=6 months, currently followed up by 1 consultant (J.S.). Ninety-two patients found evaluated status...
Information regarding the characteristics and health of women who do not attend for breast cancer screening is limited representative data are difficult to obtain.Information on age, deprivation prescriptions various medications was obtained all at two UK general practices were invited through National Health Service Breast Screening Programme. The attended did compared.Of 1064 from practices, 882 (83%) screening. attenders a similar age non-attenders but came significantly less deprived...
Ovarian cancer risk is known to be reduced amongst women who have had children, but reported associations with breastfeeding are varied. Few studies sufficient power explore reliably these by tumour histotype. In a prospective study of 1.1 million UK women, 8719 developed ovarian during follow‐up. Cox regression yielded adjusted relative risks (RRs) overall and histotype different childbearing patterns. Nulliparous 24% greater than one child, significant heterogeneity ( p = 0.01). There was...
With a range that covered most of northern Eurasia and parts North America, the cave lion (Panthera spelaea) was one widespread carnivores Late Pleistocene. Earlier ancient DNA analyses have shown it is distinct from modern lions, suggested demographic decline in Beringia during marine isotope stage 3 (MIS 3). Here, we further investigate Pleistocene population dynamics more detail by combining powerful algorithm couples MCMC with coalescent simulations under an approximate Bayesian...
Some investigators have reported an excess risk of venous thromboembolism (VTE) associated with depression and use antidepressant drugs. We explored these associations in a large prospective study UK women.
Summary The aetiology of most haematological malignancies is largely unknown. Studies migrant populations can provide insights into the relative importance genetic and environmental risk factors for these diseases. This study compares incidence rates in B ritish I ndians, P akistanis, angladeshis, lack A fricans, C aribbeans, hinese W hites E ngland from 2001 to 2007. We analysed 134 302 cancer registrations with ethnicity obtained by linkage H ospital pisodes S tatistics database. Mid‐year...
Associations between behavioural and other personal factors colorectal cancer risk have been reported to vary by tumour characteristics, but evidence is inconsistent. In a large UK-based prospective study we examined associations of 14 postulated with overall, across three anatomical sites four morphological subtypes. Among 1.3 million women, 18,518 incident cancers were identified during 13.8 (SD 3.4) years follow-up via record linkage national registry data. Cox regression yielded adjusted...
There is limited information about participation in organised population-wide screening programmes by people with disabilities.
Abstract Background Ethnic minority women are commonly reported to have more aggressive breast cancer than White women, but there is little contemporary national evidence available. Methods We analysed data from the National Cancer Registration and Analysis Service on diagnosed with invasive during 2013–2018. Multivariable logistic regression yielded adjusted odds ratios (and 95% confidence intervals) of less favourable tumour characteristics (high stage, high grade, ER negative, Her2...
Abstract Background Most previous studies of rheumatoid arthritis (RA) and cancer risk have lacked information on potential confounding factors. We investigated RA-associated risks in a large cohort women the UK, taking account shared Methods In 1996–2001, aged 50–64, who were invited for routine breast screening at 66 National Health Service (NHS) centres England Scotland, also to take part Million Women Study. Participants provided sociodemographic, lifestyle health-related factors,...
To assess the short- and long-term reproducibility of a short food group questionnaire, to compare its performance for estimating nutrient intakes in comparison with 7-day diet diary.Participants study completed questionnaire at two time points, up 2 years apart. Participants both diary few months Reproducibility was assessed by kappa statistics percentage change between questionnaires; statistics, rank correlations percentages participants classified into same opposite thirds intake.A...
Incidence rates for many cancers are lower in India than Britain and it is therefore of interest to compare British Indians whites, as well India. We present estimates Leicester, which has the largest population Indian origin Britain, also virtually complete, self-assigned, ethnicity data.We obtained data on all cancer registrations from 2001 2006 Leicester with by linkage Hospital Episode Statistics database. Age-standardised incidence were calculated whites rate ratios, adjusted age...
<h3>Objective</h3> To compare the incidence of six gastrointestinal cancers (colorectal, oesophageal, gastric, liver, gallbladder and pancreatic) among main 'non-White' ethnic groups in England (Indian, Pakistani, Bangladeshi, Black African, Caribbean Chinese) to each other Whites. <h3>Methods</h3> We analysed all 378 511 cancer registrations from 2001–2007 England. Ethnicity was obtained by linkage Hospital Episodes Statistics database we used mid-year population estimates 2001–2007....
Excess weight is associated with poor health and increased health-care costs. However, a detailed understanding of the effects excess on total hospital costs for different conditions needed.
Tubal ligation is known to be associated with a reduction in ovarian cancer risk. Associations breast, endometrial and cervical cancers have been suggested. We investigated associations for 26 site-specific large UK cohort. Study participants completed questionnaire on reproductive lifestyle factors 1996–2001, were followed death via national registries. Using Cox regression models, we estimated adjusted relative risks (RRs) among women vs without tubal ligation. In 1 278 783 previous...
Journal Article Postoperative autologous transfusion in cardiac surgery. A prospective, randomised study Get access European of Cardio-Thoracic Surgery, Volume 4, Issue 11, November 1990, Pages 595–600, https://doi.org/10.1016/1010-7940(90)90018-U Published: 01 1990
Although international comparisons reveal large geographical differences in the incidence of breast and gynaecological cancers, data for ethnic groups England remains scarce. We compared breast, ovarian, cervical endometrial cancer British Indians, Pakistanis, Bangladeshis, Black Africans, Caribbeans, Chinese Whites between 2001 2007. identified 357,476 registrations from which rates were calculated using mid-year population estimates to Ethnicity was obtained through linkage Hospital...