A5008820697- Congenital Heart Disease Studies
- Cardiac Valve Diseases and Treatments
- Cardiac Structural Anomalies and Repair
- Coronary Artery Anomalies
- Cardiovascular Issues in Pregnancy
- Infective Endocarditis Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Aortic Disease and Treatment Approaches
- Pulmonary Hypertension Research and Treatments
- Vascular anomalies and interventions
- Congenital Diaphragmatic Hernia Studies
- Tracheal and airway disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiovascular and Diving-Related Complications
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Mechanical Circulatory Support Devices
- Cardiomyopathy and Myosin Studies
- Ultrasound in Clinical Applications
- Cardiac Imaging and Diagnostics
- Advanced X-ray and CT Imaging
- Healthcare Policy and Management
- Williams Syndrome Research
- Pericarditis and Cardiac Tamponade
- Vascular Anomalies and Treatments
University of Southampton
2020-2022
Mater Dei Hospital
2009-2017
Imperial College London
1995-2015
Belfast Health and Social Care Trust
2014
Cambridge University Press
2012
University College London
1985-2003
Great Ormond Street Hospital
1966-2003
Royal Children's Hospital
2003
Hull and East Yorkshire Hospitals NHS Trust
2003
Royal Brompton Hospital
1991-2002
Life-threatening ventricular arrhythmia and sudden death remain serious late complications after tetralogy of Fallot repair. Nevertheless, there remains no clear way predicting which patients are at risk.The study population included a total 178 adult survivors (mean follow-up, 21.4 years) repair who were currently attending our clinic. Mechano-electrical relations sought in 41 the 23.6 operated on by one surgeon prospectively studied with 12-lead ECG, chest radiography, two-dimensional...
To assess the natural history, risk factors for death and deterioration of patients with Eisenmenger Syndrome.
In a series of 416 women with congenital heart disease seen in the Royal Brompton National Heart and Lung Hospital, London, Hospital Giovanni Bosco, Torino, Italy, there were 822 pregnancies. The outcomes 96 pregnancies 44 patients cyanotic studied. Patients Eisenmenger reaction excluded. divided arbitrarily into groups according to type maternal cardiac anomaly, factors influencing fetal outcome evaluated. incidence cardiovascular complications was high (32%), one death from endocarditis 2...
Pulmonary autograft replacement of the diseased aortic valve has not been widely practiced due to concerns regarding late competence and consequences creating pulmonary disease. To investigate this, fate pioneering series patients determined.The 131 hospital survivors operation at National Heart Hospital from 1967 1984 were identified their outcomes determined 1994. Age was 11 52 years, 109 male. Autograft implantation orthotopic subcoronary (107), free-standing root (20), or Dacron mounted...
Background —There is a high incidence of anomalous coronary arteries in subjects with congenital heart disease. These abnormalities can be responsible for myocardial ischemia and sudden death or damaged during surgical intervention. It difficult to define the proximal course use conventional x-ray angiography. Magnetic resonance angiography (MRCA) has been shown useful assessment 3-dimensional relationship between great vessels normal cardiac morphology but not used patients Methods Results...
OBJECTIVE--To assess the clinical course of adult patients with corrected transposition great arteries without associated anomalies. DESIGN--All anomalies were reviewed complete and echocardiographic assessment. The complications evaluated in each decade. SETTING--Tertiary centre a specific unit dealing "grown-up" adolescent congenital heart disease, designated as quaternary general hospital referral for disease. PATIENTS--18 (nine male nine female) aged 16-61 years followed 1-30 (mean 10...
<b><i>Objective</i>—To study the determinants and outcome of arrhythmias after Fontan type operation.</b> <b><i>Design</i>—Retrospective analysis data in patients operated on between 1972 1986 (follow up 5–19 years (mean 12 years)).</b> <b><i>Patients</i>—All 60 undergoing a procedure at National Heart Hospital, London, during period age (SD) 12·3 (6·8) years).</b> <b><i>Results</i>—Postoperative occurred 34 (57%), 11 (58%) 19 early postoperative deaths (within seven days) were related to...
Thirty-nine consecutive patients, aged 5 to 57 years, were followed for two 15 years with serial haemodynamic studies after removal of fixed subaortic stenosis, which was never a "membrane". Two late deaths occurred, one sudden and in congestive failure. Of 37 survivors, 25 asymptomatic could be classified as good or excellent if judged by well-being. Seven symptomatic, having had reoperation four needed long-term pacing. Evaluation, including the effect isoprenaline, showed important...
The anatomy of the systemic arterial supply to lungs is described in 30 patients with pulmonary atresia and ventricular septal defect.The pattern variable but broadly falls into two types.Multiple small arteries a widespread origin from aorta its branches are associated full development central arteries.Larger arteries, which fewer number, tend be withfailure artery development.It suggested that these types have different origin, neither type represents true bronchial arteries.The...
Aims To establish the frequency of complications in adults with small ventricular septal defects, which have not undergone surgery. Methods and Results One hundred eighty-eight aged 17–72 (mean, 29·2) years a defect were studied. They referred to national cardiac centre (National Heart Hospital) specialized grown-up congenital heart unit. thirty-eight examined 1994–95. Fifty patients (26·6%) had additional cardiovascular lesions, most commonly bicuspid aortic valve and/or coarctation....
Amiodarone is widely used in adults with congenital heart disease, but no systematic study has been published on its effects thyroid function these patients. A retrospective was performed to examine the frequency of amiodarone-associated dysfunction disease and identify any contributing factors.All (16 60 years old) were identified from a database if they had preexisting taken amiodarone for >/=6 months, currently followed up by 1 consultant (J.S.). Ninety-two patients found evaluated status...
The anatomy of the ostium primum atrial septal defect has been known since Rokitansky's description in 1875.However, until introduction cardiac catheterization and open heart surgery, information about physiology clinical features this condition lagged behind knowledge morbid anatomy.Attempts at surgical correction have influenced natural history, prognosis untreated defect, present scanty, is unlikely to increase as scope surgery widens.The factors severely disabled patients with an those...
Two patients, aged 4 and 23 years, with congenital aneurysms of the coronary arteries are described.The pathology was different in each required surgical techniques involving obliteration aneurysm or establishing flow a saphenous vein graft.The clinical radiologicalfeatures described.Aneurysms rare, it is only after advent arteriography that they have been diagnosed life.They may be due to atherosclerosis, necrotizing arteritis, myocotic emboli, syphilis, trauma, occasionally congenital.The...
Twenty patients with ventricular septal defect and aortic regurgitation had surgical correction using cardiopulmonary bypass. Direct suture of the through aorta repair or replacement valve were performed. Homograft was preferred to associated less after operation. There one operative death late due regurgitation. Follow-up for 1 6 years showed that 17 18 survivors have a satisfactory result.