A5058622525- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Hip and Femur Fractures
- Orthopedic Infections and Treatments
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Shoulder Injury and Treatment
- Hip disorders and treatments
- Bone health and osteoporosis research
- Cardiac, Anesthesia and Surgical Outcomes
- Bone health and treatments
- Rheumatoid Arthritis Research and Therapies
- Vasculitis and related conditions
- Pelvic and Acetabular Injuries
- Shoulder and Clavicle Injuries
- Orthopedic Surgery and Rehabilitation
- Health Systems, Economic Evaluations, Quality of Life
- Musculoskeletal Disorders and Rehabilitation
- Bone fractures and treatments
- Musculoskeletal pain and rehabilitation
- Healthcare Policy and Management
- Chronic Disease Management Strategies
- Parathyroid Disorders and Treatments
- Primary Care and Health Outcomes
- Otitis Media and Relapsing Polychondritis
Southmead Hospital
2017-2025
National Institute for Health Research
2015-2025
University of Bristol
2011-2025
Nuffield Orthopaedic Centre
2016-2025
NIHR Bristol Biomedical Research Centre
2017-2025
University Hospitals Bristol NHS Foundation Trust
2019-2025
University Hospitals Bristol and Weston NHS Foundation Trust
2022-2025
University of Glasgow
2025
University of Oxford
2015-2024
NIHR Bristol Cardiovascular Biomedical Research Unit
2023-2024
Large-scale and contemporary population-based studies of heart failure incidence are needed to inform resource planning research prioritisation but current evidence is scarce. We aimed assess temporal trends in prevalence a large general population cohort from the UK, between 2002 2014.For this study, we used linked primary secondary electronic health records 4 million individuals Clinical Practice Research Datalink (CPRD), that representative UK terms age sex. Eligible patients were aged 16...
<h3>Objectives</h3> Data on the incidence of symptomatic osteoarthritis (OA) are scarce. We estimated clinical hip, knee and hand OA, studied effect prevalent OA joint-specific incident OA. <h3>Methods</h3> SIDIAP contains primary care records for>5 million people from Catalonia (Spain). Participants aged ≥40 years with an diagnosis knee, hip or between 2006 2010 were identified using International Classification Diseases (ICD)-10 codes. Incidence rates female-to-male rate ratios (RRs)...
BackgroundTotal joint replacements for end-stage osteoarthritis of the hip and knee are cost-effective demonstrate significant clinical improvement. However, robust population based lifetime-risk data implant revision not available to aid patient decision making, which is a particular problem in young groups deciding on best-timing surgery.MethodsWe did survival analysis all patients within Clinical Practice Research Datalink who had undergone total replacement or replacement. These were...
BackgroundTotal knee replacement (TKR) or unicompartmental (UKR) are options for end-stage osteoarthritis. However, comparisons between the two procedures confounded by differences in baseline characteristics of patients undergoing either procedure and insufficient reporting endpoints other than revision. We aimed to compare adverse outcomes each matched patients.MethodsWith propensity score techniques, we compared TKR UKR National Joint Registry England Wales. The started collecting data...
BackgroundArthroscopic sub-acromial decompression (decompressing the space by removing bone spurs and soft tissue arthroscopically) is a common surgery for subacromial shoulder pain, but its effectiveness uncertain. We did study to assess investigate mechanism surgical decompression.MethodsWe multicentre, randomised, pragmatic, parallel group, placebo-controlled, three-group trial at 32 hospitals in UK with 51 surgeons. Participants were patients who had pain least 3 months intact rotator...
Objective. To identify pre-operative predictors of patient-reported outcomes primary total knee replacement (TKR) surgery.
To develop and validate revised classification criteria for eosinophilic granulomatosis with polyangiitis (EGPA).Patients vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in five phases: (1) identification of candidate items using consensus methodology, (2) prospective collection present at the time diagnosis, (3) data-driven reduction number items, (4) expert panel review cases to define reference diagnosis (5) derivation a points-based risk...
To develop and validate revised classification criteria for granulomatosis with polyangiitis (GPA).Patients vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in five phases: (1) identification of candidate items using consensus methodology, (2) prospective collection present at the time diagnosis, (3) data-driven reduction number items, (4) expert panel review cases to define reference diagnosis (5) derivation a points-based risk score disease...
Whether to use total or unicompartmental knee replacement (TKA/UKA) for end-stage osteoarthritis remains controversial. Although UKA results in a faster recovery, lower rates of morbidity and mortality fewer complications, the long-term revision rate is substantially higher than that TKA. The effect each intervention on patient-reported outcome unclear. aim this study was determine whether six-month measures (PROMs) are better patients after TKA UKA, using data from large national joint...
Using a large cohort of hip fracture patients, we estimated hospital costs to be £14,163 and £2139 in the first second year following fracture, respectively. Second non-hip fractures were major cost drivers. There is strong economic incentive identify cost-effective approaches for prevention. The purpose this study was estimate up 2 years post-fracture compare before after index fracture. A patients aged over 60 admitted with UK region between 2003 2013 identified from records followed until...
Objective To develop and validate updated classification criteria for giant cell arteritis (GCA). Methods Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in six phases: (1) identification of candidate items, (2) prospective collection items present at the time diagnosis, (3) expert panel review cases, (4) data‐driven reduction (5) derivation a points‐based risk score development data set (6) validation independent set. Results...
Background: High-volume surgeons attain the best results following unicompartmental knee replacement (UKR), but exact relationship between caseload and outcome is not clear. It known whether this effect due to patient selection or surgical skill nor a similar seen in total (TKR). The aim of study was quantify on survival both TKR UKR. Methods: This based 459,280 records (422,149 TKRs 37,131 UKRs) from National Joint Registry for England Wales. caseload-outcome characterized graphically...
To develop and validate classification criteria for microscopic polyangiitis (MPA).Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in five phases: (1) identification of candidate items using consensus methodology, (2) prospective collection present at the time diagnosis, (3) data-driven reduction number items, (4) expert panel review cases to define reference diagnosis (5) derivation a points-based risk score disease...
Despite considerable improvements in heart failure care, mortality rates among patients high-income countries have changed little since the early 2000s. Understanding reasons underlying these trends may provide valuable clues for developing more targeted therapies and public health strategies.To investigate following a new diagnosis of examine changes over time by cause death important patient features.This population-based retrospective cohort study analyzed anonymized electronic records...
To develop and validate revised classification criteria for granulomatosis with polyangiitis (GPA).
Objective To develop and validate new classification criteria for Takayasu arteritis (TAK). Methods Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in six phases: (1) identification of candidate items, (2) collection items present at diagnosis, (3) expert panel review cases, (4) data‐driven reduction (5) derivation a points‐based score development data set (6) validation independent set. Results consisted 316 cases TAK 323...
Objective To develop and validate classification criteria for microscopic polyangiitis (MPA). Methods Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 5 phases: 1) identification of candidate items using consensus methodology, 2) prospective collection present at the time diagnosis, 3) data‐driven reduction number items, 4) expert panel review cases to define reference 5) derivation a points‐based risk score disease...
Objective To develop and validate updated classification criteria for giant cell arteritis (GCA). Methods Patients with vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 6 phases: 1) identification of candidate items, 2) prospective collection items present at the time diagnosis, 3) expert panel review cases, 4) data‐driven reduction 5) derivation a points‐based risk score development data set, 6) validation independent set. Results set...
Objective To develop and validate revised classification criteria for eosinophilic granulomatosis with polyangiitis (EGPA). Methods Patients vasculitis or comparator diseases were recruited into an international cohort. The study proceeded in 5 phases: 1) identification of candidate items using consensus methodology, 2) prospective collection present at the time diagnosis, 3) data‐driven reduction number items, 4) expert panel review cases to define reference 5) derivation a points‐based...