A5091610751- Maternal and fetal healthcare
- Maternal and Perinatal Health Interventions
- Pregnancy and preeclampsia studies
- Preterm Birth and Chorioamnionitis
- Pregnancy-related medical research
- Neonatal Respiratory Health Research
- Birth, Development, and Health
- Global Maternal and Child Health
- Blood Coagulation and Thrombosis Mechanisms
- Ectopic Pregnancy Diagnosis and Management
- Cardiovascular Issues in Pregnancy
- Reproductive System and Pregnancy
- Assisted Reproductive Technology and Twin Pregnancy
- Reproductive Health and Contraception
- Pregnancy and Medication Impact
- Venous Thromboembolism Diagnosis and Management
- Infant Development and Preterm Care
- Emergency and Acute Care Studies
- Maternal Mental Health During Pregnancy and Postpartum
- Gestational Diabetes Research and Management
- COVID-19 Impact on Reproduction
- Trauma and Emergency Care Studies
- Hemophilia Treatment and Research
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Platelet Disorders and Treatments
Leiden University Medical Center
2011-2025
University Medical Center Utrecht
2016-2025
Wilhelmina Children's Hospital
2016-2025
Leiden University
2007-2025
Utrecht University
2017-2025
The University of Adelaide
2018-2023
University of Oxford
2023
Universidade Federal de São Paulo
2023
UNSW Sydney
2023
Universidade Estadual de Campinas (UNICAMP)
2023
To compare the effect of induction labour with a policy expectant monitoring for intrauterine growth restriction near term.
Progesterone is essential for the maintenance of pregnancy. However, whether progesterone supplementation in first trimester pregnancy would increase rate live births among women with a history unexplained recurrent miscarriages uncertain.
To compare maternal mortality in eight countries with enhanced surveillance systems.Descriptive multicountry population based study.Eight permanent systems using methods to identify, document, and review deaths. The most recent available aggregated data were collected for three year periods France, Italy, the UK five Denmark, Finland, Netherlands, Norway, Slovakia.297 835 live births Denmark (2013-17), 301 169 Finland (2008-12), 2 435 583 France (2013-15), 1 281 986 Italy 856 572 Netherlands...
Background At present, there is insufficient evidence to guide appropriate management of women with preterm prelabor rupture membranes (PPROM) near term. Methods and Findings We conducted an open-label randomized controlled trial in 60 hospitals The Netherlands, which included non-laboring >24 h PPROM between 34+0 37+0 wk gestation. Participants were randomly allocated a 1∶1 ratio induction labor (IoL) or expectant (EM) using block randomization. main outcome was neonatal sepsis. Secondary...
Recurrent miscarriage affects 1-2% of women. In more than half all recurrent the cause still remains uncertain. Thrombophilia has been identified in about 50% women with and thromboprophylaxis suggested as an option treatment. A randomised double-blind (for aspirin) multicentre trial was performed among 207 three or consecutive first trimester (<13 weeks) miscarriages, two second (13-24 miscarriages one third fetal loss combined miscarriage. Women were analysed for thrombophilia. After...
Increasing evidence suggests that preeclampsia is associated with complement dysregulation. The origin of dysregulation in unknown, and further unraveling this mechanism could provide both diagnostic tools therapeutic targets. Because the placenta believed to play a crucial role pathogenesis preeclampsia, we investigated placentas from preeclamptic women (n=28) controls (n=44) for presence activation products. Immunohistochemistry was performed C1q, mannose-binding lectin, properdin, C4d....
It has been hypothesized that internal tocodynamometry, as compared with external monitoring, may provide a more accurate assessment of contractions and thus improve the ability to adjust dose oxytocin effectively, resulting in fewer operative deliveries less fetal distress. However, few data are available test this hypothesis.We performed randomized, controlled trial six hospitals The Netherlands compare tocodynamometry monitoring uterine activity women for whom induced or augmented labor...
Maternal infections are an important cause of maternal mortality and severe morbidity. We report the main findings WHO Global Sepsis Study, which aimed to assess frequency in health facilities, according characteristics outcomes, coverage core practices for early identification management.We did a facility-based, prospective, 1-week inception cohort study 713 facilities providing obstetric, midwifery, or abortion care, where women could be admitted because complications pregnancy,...
To estimate the performance of combining cervical length measurement with fetal fibronectin testing in predicting delivery women symptoms preterm labor.We conducted a prospective nationwide cohort study all 10 perinatal centers The Netherlands. Women labor between 24 and 34 weeks gestation intact membranes were included. In women, qualitative (0.050-microgram/mL cutoff) performed. Logistic regression was used to predict spontaneous within 7 days after testing. A risk less than 5%,...
<b>Objective</b> To determine women's satisfaction with pain relief using patient controlled analgesia remifentanil compared epidural during labour. <b>Design</b> Multicentre randomised equivalence trial. <b>Setting</b> 15 hospitals in the Netherlands. <b>Participants</b> Women an intermediate to high obstetric risk intention deliver vaginally. exclude a clinically relevant difference of more than 10%, we needed include 1136 women. Because missing values for this number was increased 1400...
Background and objectives Progesterone is essential to maintain a healthy pregnancy. Guidance from the Royal College of Obstetricians Gynaecologists Cochrane review called for definitive trial test whether or not progesterone therapy in first trimester could reduce risk miscarriage women with history unexplained recurrent (RM). The PROMISE was conducted answer this question. A concurrent cost-effectiveness analysis conducted. Design setting randomised, double-blind, placebo-controlled,...