A5043238593- Ovarian function and disorders
- Reproductive Biology and Fertility
- Ectopic Pregnancy Diagnosis and Management
- Endometriosis Research and Treatment
- Gynecological conditions and treatments
- Assisted Reproductive Technology and Twin Pregnancy
- Uterine Myomas and Treatments
- Maternal and fetal healthcare
- Reproductive System and Pregnancy
- Maternal and Perinatal Health Interventions
- Reproductive Health and Contraception
- Pregnancy-related medical research
- Ovarian cancer diagnosis and treatment
- Pregnancy and preeclampsia studies
- Menstrual Health and Disorders
- Pregnancy and Medication Impact
- Sperm and Testicular Function
- Male Reproductive Health Studies
- Sexual Differentiation and Disorders
- Pharmacological Effects and Toxicity Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Hip and Femur Fractures
- Gout, Hyperuricemia, Uric Acid
- Gestational Trophoblastic Disease Studies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
Nottingham University Hospitals NHS Trust
2008-2021
Queen's Medical Centre
2009-2021
University of Birmingham
2019
Miscarriage Association
2019
University of Nottingham
2007-2015
Bleeding in early pregnancy is strongly associated with loss. Progesterone essential for the maintenance of pregnancy. Several small trials have suggested that progesterone therapy may improve outcomes women who bleeding pregnancy.We conducted a multicenter, randomized, double-blind, placebo-controlled trial to evaluate progesterone, as compared placebo, vaginal Women were randomly assigned receive suppositories containing either 400 mg or matching placebo twice daily, from time at which...
BackgroundThe anti-progesterone drug mifepristone and the prostaglandin misoprostol can be used to treat missed miscarriage. However, it is unclear whether a combination of more effective than administering alone. We investigated treatment with plus would result in higher rate completion miscarriage compared alone.MethodsMifeMiso was multicentre, double-blind, placebo-controlled, randomised trial 28 UK hospitals. Women were eligible for enrolment if they aged 16 years older, diagnosed by...
Abstract Objective To estimate the prevalence of congenital uterine anomalies in subfertile women and to evaluate their influence on early pregnancy following assisted reproduction treatment (ART). Methods We prospectively recruited 1402 subjects undergoing ART over a period 5 years from 2005 2009. Three‐dimensional transvaginal sonography was performed follicular phase menstrual cycle (days 2–5) repeated late 10–14) if shape cavity could not be assessed at first scan. All who conceived were...
Abstract Objective To assess the reliability of automated measurements total antral follicle count (AFC) made using Sono‐Automatic Volume Count (SonoAVC), and to compare these two‐dimensional (2D) manual three‐dimensional (3D) techniques. Methods Fifty‐five subjects aged under 40 years who had 3D transvaginal ultrasound examination in early follicular phase their menstrual cycle were prospectively recruited. datasets acquired subsequently analyzed. The AFC (2–10 mm follicles) was calculated...
To compare two-dimensional (2D) ultrasound imaging with automated three-dimensional (3D) for the measurement of antral follicle number and size.Twenty-four subjects aged < 40 years underwent transvaginal examination (Voluson E8) in early follicular phase menstrual cycle. A 2D scan both ovaries was performed; each identified then measured by taking mean two diameters. 3D dataset acquired analyzed using Sonography-based Automated Volume Count (SonoAVC). The time taken to measure size all...
Oral contraceptive pills suppress the hypothalomo-pituitary axis, which can affect ultrasound and endocrine markers used to examine ovarian reserve. The objective of this study was quantify functional reserve in women using a combined oral pill (COCP) for more than year.This prospective case-control involving healthy volunteers: 34 year COCP with hormone-free interval (HFI) were compared 36 normo-ovulatory, age-matched controls who had not hormonal contraception within last year. Volunteers...
To quantify the intracycle variation in markers of ovarian reserve measured by antral follicle counts stratified size using three-dimensional (3D) ultrasound and anti-Müllerian hormone (AMH) women with normal menstrual cycles.Healthy volunteers cycles were prospectively recruited. Three-dimensional examination blood test performed early (F1) mid-follicular (F2) phases periovulatory (PO) luteal (LU) one cycle. Antral follicles 'sonography-based automated volume calculation' post processing...
To assess how nausea and vomiting in pregnancy (NVP) hyperemesis gravidarum (HG) are managed treated across primary secondary care.Population-based cohort.Medical records (CPRD-GOLD) from England.417 028 pregnancies during 1998-2014.Proportions of with recorded NVP/HG diagnoses, care treatment, hospital admissions were calculated. Multinomial logistic regression was employed to estimate adjusted relative risk ratios (aRRRs) 99% confidence intervals (CIs) for the association between...
ABSTRACT Objectives To determine anxiety levels of women presenting to an early pregnancy assessment unit ( EPAU ) with abdominal pain and/or vaginal bleeding and assess how these change over time according ultrasonographic diagnosis. Methods We undertook a prospective cohort study in large UK teaching hospital. Women (< 12 weeks' gestation) for the first were eligible inclusion study. State assessed using standardized short form Spielberger's state–trait inventory STAI on three occasions...
Background Progesterone is essential for a healthy pregnancy. Several small trials have suggested that progesterone therapy may rescue pregnancy in women with early bleeding, which symptom strongly associated miscarriage. Objectives (1) To assess the effects of vaginal micronised bleeding first 12 weeks (2) evaluate cost-effectiveness bleeding. Design A multicentre, double-blind, placebo-controlled, randomised trial Setting total 48 hospitals UK. Participants Women aged 16–39 years...
Are all patients undergoing chemotherapy for long-term sperm banking at risk of permanent sterility? Male fertility is generally lower in men with cancer and patient groups are azoospermia. Careful management required to ensure that samples not stored excessively long periods should they be required. A retrospective analysis 1688 records prospective recall semen testing were performed. Pre-therapy was compared a group pre-vasectomy as comparator. Those who fail bank spermatozoa, rates...
Endometriosis is a common condition, affecting somewhere between 5% and 60% of women reproductive age approximately 2 million in the UK. The exact prevalence difficult to ascertain varies according diagnostic criteria used populations studied, varying from 50% without symptoms, 40 with dysmenorrhea, 20 30% subfertility1, 2. etiology unknown, but disease characterized by objective demonstration endometrial-like tissue outside uterus. condition seen predominantly age, it occurs all ethnic...
Abstract We present a case of Cesarean scar ectopic pregnancy, complicated by the persistence clinical symptoms despite rapid and complete biochemical response to single systemic injection methotrexate. A 34‐year‐old woman with three previous sections was diagnosed pregnancy following @ in‐vitro fertilization treatment. The diagnosis suggested three‐dimensional (3D) ultrasound scan confirmed magnetic resonance imaging (MRI). Management involved administration methotrexate follow‐up serial...
Sono-automatic volume calculation (SonoAVC) automatically identifies and measures the dimensions of hypoechogenic areas within datasets acquired using three-dimensional ultrasound. The objective this study was to evaluate predictive value automated antral follicle counts according their relative sizes in women undergoing assisted reproduction treatment (ART). A total 156 subjects aged ≤40 years with a baseline FSH ≤15 IU that undergo first cycle ART were prospectively recruited. SonoAVC used...
Objectives To assess the cost‐effectiveness of progesterone compared with placebo in preventing pregnancy loss women early vaginal bleeding. Design Economic evaluation alongside a large multi‐centre randomised placebo‐controlled trial. Setting Forty‐eight UK NHS units. Population Four thousand one hundred and fifty‐three aged 16–39 years bleeding ultrasound evidence an intrauterine sac. Methods An incremental analysis was performed from National Health Service (NHS) Personal Social Services...
Trial design A randomised, parallel-group, double-blind, placebo-controlled multicentre study with health economic and nested qualitative studies to determine if mifepristone (Mifegyne ® , Exelgyn, Paris, France) plus misoprostol is superior alone for the resolution of missed miscarriage. Methods Women diagnosed miscarriage in first 14 weeks pregnancy were randomly assigned (1 : 1 ratio) receive 200 mg oral or matched placebo, followed by 800 μg 2 days later. web-based randomisation system...
The project aim was to investigate the impact of reconfiguring gynaecology services on key performance indicators a University Hospital NHS Trust in UK. reconfiguration involved centralisation elective one hospital site and emergency other. Data measuring outcomes Trust's (clinical outcomes, patient experience, staff satisfaction, teaching/training, research/development value for money) were collected. Two time periods, 12 months before after March 2011, compared all outcome measures except...
"Rectus sheath haematoma in pregnancy: A clinical challenge." Journal of Obstetrics and Gynaecology, 26(8), pp. 822–823