A5059973729- Mental Health and Psychiatry
- Health Systems, Economic Evaluations, Quality of Life
- Opioid Use Disorder Treatment
- Substance Abuse Treatment and Outcomes
- Smoking Behavior and Cessation
- Psychosomatic Disorders and Their Treatments
- Child and Adolescent Health
- Health Policy Implementation Science
- Stroke Rehabilitation and Recovery
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Diagnosis and Treatment of Venous Diseases
- Asthma and respiratory diseases
- Pain Mechanisms and Treatments
- Physical Activity and Health
- Health and Wellbeing Research
- Pressure Ulcer Prevention and Management
- Botulinum Toxin and Related Neurological Disorders
- Ethics in Clinical Research
- Pain Management and Opioid Use
- School Health and Nursing Education
- Homelessness and Social Issues
- Health disparities and outcomes
- Behavioral Health and Interventions
- Respiratory and Cough-Related Research
- Wound Healing and Treatments
Sheffield Health and Social Care NHS Foundation Trust
2019-2025
University of York
2023
University of Sheffield
2005-2019
Northern General Hospital
2005
People with severe mental illnesses such as schizophrenia are three times more likely to smoke than the wider population, contributing widening health inequalities. Smoking remains largest modifiable risk factor for this inequality, but people illness have not historically engaged smoking cessation services. We aimed test effectiveness of a combined behavioural and pharmacological intervention targeted specifically at illness.In (SCIMITAR+) trial, pragmatic, randomised controlled study, we...
Diabetic peripheral neuropathic pain (DPNP) is common and often distressing. Most guidelines recommend amitriptyline, duloxetine, pregabalin, or gabapentin as initial analgesic treatment for DPNP, but there little comparative evidence on which one best whether they should be combined. We aimed to assess the efficacy tolerability of different combinations first-line drugs DPNP.OPTION-DM was a multicentre, randomised, double-blind, crossover trial in patients with DPNP mean daily numerical...
Background People with multiple and persistent physical symptoms have impaired quality of life poor experiences health care. We aimed to evaluate the effectiveness a community-based Symptoms Clinic intervention in people symptoms. Trial design Pragmatic multicentre individually randomised parallel group clinical trial. Methods Participants: Recruitment was between December 2018 2021 four areas UK. Eligibility based on electronic records, healthcare use (PHQ-15 10 20) which were not due other...
SPACES (Supporting Physical Activity through Co-production in people with Severe Mental Illness) is a study which aims to develop an intervention increase physical activity created and for severe mental ill health (SMI), their carers professionals involved and/or health. People SMI are less physically active than the general population have increased likelihood of experiencing long-term conditions such as cardiovascular respiratory diseases, diabetes obesity. The team employed comprehensive...
Background Asthma episodes and deaths are known to be seasonal. A number of reports have shown peaks in asthma school-aged children associated with the return school following summer vacation. fall prescription collection month August has been observed, was an increase unscheduled contacts after September. Objective The primary objective study assess whether or not a NHS-delivered public health intervention reduces September peak medical contacts. Design Cluster randomised trial, unit...
Abstract Introduction Evidence suggests that smokers can successfully quit, remain abstinent or reduce smoking during a smoke-free mental health inpatient stay, provided behavioral/pharmacological support are offered. However, few evidence-based strategies to prevent the return prehospital behaviors post-discharge exist. Aims and Methods We report development of an intervention designed smoking-related behavior change following discharge from stay. followed Behavior Change Wheel (BCW)...
Within the UK, during September, there is a pronounced increase in number of unscheduled medical contacts by school-aged children (4–16 years) with asthma. It thought that this might be caused return back to school after summer holidays, suddenly mixing other again and picking up viruses which could affect their There also drop prescriptions administered August. possible therefore not taking medication as they should contributing them becoming ill when school. hoped simple intervention from...
Background The mainstay of treatment for diabetic peripheral neuropathic pain is pharmacotherapy, but the current National Institute Health and Care Excellence guideline not based on robust evidence, as treatments their combinations have been directly compared. Objectives To determine most clinically beneficial, cost-effective tolerated pathway pain. Design A randomised crossover trial with health economic analysis. Setting Twenty-one secondary care centres in UK. Participants Adults a 7-day...
Abstract Exercise is recommended as an adjunct treatment, alongside compression therapy to increase venous leg ulcer (VLU) wound healing times, however, there are no published programmes available that support patients exercise at home on their own. To develop exercise‐based lifestyle intervention feasible and acceptable people with VLUs, a participatory approach was utilised. Clinicians, researchers, living VLUs collaborated in the design of “FISCU Home”. Two focus groups nine interviews...
Aims We describe how patient and public involvement (PPI) was integrated into the design of an intervention for a randomised controlled trial (RCT) based within primary care. The RCT, known as PLEASANT trial, aimed to reduce unscheduled medical contacts in children with asthma associated start new school year September simple postal intervention, highlighting importance maintaining medication helping prevent increased exacerbations.PPI is key feature UK health research policy, often...
Persistent physical symptoms (which cannot be adequately attributed to disease) affect around 1 million people (2% of adults) in the UK. They patients' quality life and account for at least one third referrals from General Practitioners (GPs) specialists. These give patients little benefit but have a real cost health services time diagnostic resources. The clinic has been designed help make sense persistent (especially if medical tests negative) reduce impact on daily life. This pragmatic,...
Large observational datasets such as Clinical Practice Research Datalink (CPRD) provide opportunities to conduct clinical studies and economic evaluations with efficient designs. Our objectives were report the evaluation methodology for a cluster randomised controlled trial (RCT) of UK NHS-delivered public health intervention children asthma that was evaluated using CPRD describe impact this on results. identified eligible patients predefined diagnostic codes captured 1-year pre-...
Background There is a high prevalence of smoking among people with severe mental ill health (SMI). Helping SMI to quit could improve their and longevity, reduce inequalities. However, those are less likely access engage routine cessation services than the general population. Objectives To compare clinical effectiveness cost-effectiveness bespoke (BSC) intervention usual stop for SMI. Design A pragmatic, two-arm, individually randomised controlled trial. Setting Primary care secondary in...
Abstract Background: Recruitment of general practices and their patients into research studies is frequently reported as a challenge. The Preventing Lessening Exacerbations Asthma in School-aged children Associated with New Term (PLEASANT) trial recruited 142 practices, across England Wales delivered the study intervention to time target. Aims: To describe process recruitment used within cluster randomised PLEASANT present results on factors that influenced recruitment. Methods: Data were...
Around 246 million people globally suffer from depression. Physical activity (PA) can reduce the risk of depression by 30% and is recognised as an effective treatment for mild-to-moderate (MMD). However, a high proportion patients with MMD are currently inactive implementation PA adherent not well understood. This study contributes to growing body research exploring how support who experiencing increase their levels (i.e. initiation maintenance). It investigated which factors individuals...
Abstract Background Venous leg ulcers (VLUs) heal slowly, are painful for patients and costly healthcare systems; they also affect patients’ quality of life. Previous work suggests that supervised exercise training used in combination with compression therapy may offer clinical benefits. However, a large population people VLUs unable to access such an intervention due frailty age. Objectives To assess the feasibility ‘FISCU Home’ (a co-designed, 12-week home-based self-managed lifestyle...
Severe mental ill health (SMI) includes schizophrenia, bipolar disorder and schizoaffective is associated with premature deaths when compared to people without SMI. Over 70% of those are attributed preventable conditions, which have the potential be positively affected by adoption healthy behaviours, such as physical activity. People SMI generally less active than face unique barriers being physically active. Physical activity interventions for demonstrate promise, however, there important...
ABSTRACT Introduction Thousands of patients with mental illness are admitted to acute adult health wards every year in England, where local guidance recommends that all settings be entirely smokefree. Mental trusts presently invest substantial effort and resources implement smokefree policies deliver tobacco dependence treatment patients. Providing adequate support can help smokers remain abstinent or quit smoking during their inpatient stay beyond. At present, little is known about how best...
In line with national guidance, mental health Trusts in England are implementing complete smoke-free policies. We investigated inpatients' changes smoking behavior, tobacco dependence, vaping, and motivation to stop between pre-admission post-discharge.