A5057527457- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Ethics in Clinical Research
- Health disparities and outcomes
- Cerebral Palsy and Movement Disorders
- Smoking Behavior and Cessation
- Balance, Gait, and Falls Prevention
- Health Policy Implementation Science
- Diabetic Foot Ulcer Assessment and Management
- Mobile Health and mHealth Applications
- Behavioral Health and Interventions
- Dental Health and Care Utilization
- COVID-19 and Mental Health
- Chronic Disease Management Strategies
- Healthcare Systems and Technology
- Delphi Technique in Research
- Healthcare cost, quality, practices
- Family and Disability Support Research
- Orthopedic Surgery and Rehabilitation
- Survey Methodology and Nonresponse
- Noise Effects and Management
- Health, psychology, and well-being
- Total Knee Arthroplasty Outcomes
- Bone fractures and treatments
- Language Development and Disorders
University of York
2016-2025
Cardiff University
2019-2023
University of Leeds
2023
University of Dundee
2023
Department of Medical Sciences
2019-2023
University of Sheffield
2023
Northumbria Healthcare NHS Foundation Trust
2019
Manchester Metropolitan University
2000
University of Salford
1976
People with severe mental illnesses such as schizophrenia are three times more likely to smoke than the wider population, contributing widening health inequalities. Smoking remains largest modifiable risk factor for this inequality, but people illness have not historically engaged smoking cessation services. We aimed test effectiveness of a combined behavioural and pharmacological intervention targeted specifically at illness.In (SCIMITAR+) trial, pragmatic, randomised controlled study, we...
BackgroundOlder adults were more likely to be socially isolated during the COVID-19 pandemic, with increased risk of depression and loneliness. We aimed investigate whether a behavioural activation intervention delivered via telephone could mitigate loneliness in at-risk older people pandemic.MethodsBASIL+ (Behavioural Activation Social Isolation) was pragmatic randomised controlled trial conducted among patients recruited from general practices England Wales, designed assess effectiveness...
Background Older adults, including those with long-term conditions (LTCs), are vulnerable to social isolation. They likely have become more socially isolated during the Coronavirus Disease 2019 (COVID-19) pandemic, often due advice “shield” protect them from infection. This places at particular risk of depression and loneliness. There is a need for brief scalable psychosocial interventions mitigate psychological impacts Behavioural activation (BA) credible candidate intervention, but trial...
This study assessed the feasibility and acceptability of two common types exercise training-high-intensity interval training (HIIT) moderate-intensity continuous (MICT)-in adults with Crohn's disease (CD).In this mixed-methods pilot trial, participants quiescent or mildly-active CD were randomly assigned 1:1:1 to HIIT, MICT usual care control, followed up for 6 months. The HIIT groups offered three sessions per week first 12 weeks. Feasibility outcomes included rates recruitment, retention,...
Oral language skills provide the foundation for formal education, yet many children enter school with weaknesses. This study evaluated efficacy of a new enrichment programme, Nuffield Early Language Intervention-Preschool (NELI Preschool), delivered to in year before they education.
Treatment of prostate cancer with androgen deprivation therapy (ADT) is associated metabolic changes that have been linked to an increase in cardiovascular risk. This randomised controlled trial investigated the effects a 12-week lifestyle intervention included supervised exercise training and dietary advice on markers risk 50 men long-term ADT recruited on-going study investigating such quality life. Participants were randomly allocated receive or usual care. Cardiovascular outcomes...
Laura Clark and colleagues assess the allocation concealment methods in a sample of randomised controlled trial publications
Background Falls are a serious cause of morbidity and cost to individuals society. Evidence suggests that foot problems inappropriate footwear may increase the risk falling. Podiatric interventions could help reduce falls; however, there is limited evidence regarding their clinical effectiveness cost-effectiveness. Objectives To determine cost-effectiveness multifaceted podiatry intervention for preventing falls in community-dwelling older people at falling, relative usual care. Design A...
Abstract Objectives This multicentre, assessor‐blinded, two‐arm cluster randomized trial evaluated the clinical and cost‐effectiveness of a behaviour change intervention promoting toothbrushing for preventing dental caries in UK secondary schools. Methods Pupils aged 11–13 years with their own mobile telephone attending schools above average free school meals eligibility were (at year‐group level) to receive lesson twice‐daily text messages or usual care. Year‐groups ( n = 84) from 42...
Background Depression alongside multiple long-term conditions (MLTCs) in older adults poses a critical public health challenge, worsening physical and mental increasing healthcare costs. COVID-19 restrictions further exacerbated these impacts. Behavioural activation (BA) shows promise as remote intervention for depression during isolation, but its cost-effectiveness depressed, socially isolated remains uncertain. Objective This study aimed to assess the cost-utility of BA versus usual care...
Abstract Background Older adults were more likely to be socially isolated during the COVID-19 pandemic, with increased risk of depression and loneliness. The Behavioural Activation in Social Isolation (BASIL+) trial investigated whether a (BA) intervention delivered remotely could mitigate loneliness at-risk older people pandemic. Methods We undertook multicentre randomised controlled [ISRCTN63034289] BA among (65+) multiple long-term health conditions, including low mood or depression. was...
Background Low participant recruitment and retention rates are a significant barrier to successful Randomised Controlled Trials (RCTs). A Study Within Trial (SWAT) is an effective way explore which trial delivery methods may be useful for improving rates. Infographics information tool that improve participants’ understanding of the thus or This SWAT was embedded within Behavioural Activation in Social Isolation (BASIL+) RCT. BASIL+ delivered during Covid-19 pandemic evaluated clinical...
Background Falls are a major cause of morbidity among older people. A multifaceted podiatry intervention may reduce the risk falling. This study evaluated such an intervention. Design Pragmatic cohort randomised controlled trial in England and Ireland. 1010 participants were (493 to Intervention group 517 Usual Care) either: intervention, including foot ankle exercises, orthoses and, if required, new footwear, falls prevention leaflet or usual treatment plus leaflet. The primary outcome was...
Objectives Antiepileptic and antiarrhythmic drugs inhibit voltage-gated sodium (Na + ) channels (VGSCs), preclinical studies show that these medications reduce tumour growth, invasion metastasis. We investigated the association between VGSC inhibitor use survival in patients with breast, bowel prostate cancer. Design Retrospective cohort study. Setting Individual electronic primary healthcare records extracted from Clinical Practice Research Datalink. Participants Records for 132 996 a...
Abstract Metastasis is the leading cause of cancer-related deaths. Voltage-gated sodium channels (VGSCs) regulate invasion and metastasis. Several VGSC-inhibiting drugs reduce metastasis in murine cancer models. We aimed to test hypothesis that patients taking who developed live longer than those not these drugs. A cohort study was performed on primary care data from QResearch database, including with breast, bowel or prostate cancer. Cox proportional hazards regression used compare survival...
Introduction Police officers frequently come into contact with individuals mental health problems. Specialist training in this area for police may improve how they respond to problems; however, evidence support is sparse. This study evaluated the effectiveness of one bespoke package frontline relative routine training. Design Pragmatic, two-armed cluster randomised controlled trial force England. stations North Yorkshire were receiving either a or The primary outcome was number incidents...
Background Home oxygen therapy (HOT) is commonly used for patients with severe chronic heart failure (CHF) who have intractable breathlessness. There no trial evidence to support its use. Objectives To detect whether or not there was a quality-of-life benefit from HOT given as long-term (LTOT) at least 15 hours per day in the home, including overnight hours, compared best medical (BMT) severely symptomatic CHF. Design A pragmatic, two-arm, randomised controlled recruiting It included linked...
Randomised controlled trials are generally regarded as the 'gold standard' experimental design to determine effectiveness of an intervention. Unfortunately, many either fail recruit sufficient numbers participants, or recruitment takes longer than anticipated. The current embedded trial evaluates optimised patient information sheets on participants in a falls prevention trial.A three-arm, randomised methodology was conducted within National Institute for Health Research-funded REducing Falls...
Abstract Aims Morphine is shown to relieve chronic breathlessness in obstructive pulmonary disease. There are no definitive data people with heart failure. We aimed determine the effectiveness and cost‐effectiveness of 12 weeks morphine therapy for relief failure compared placebo. Methods results Parallel group, double‐blind, randomized, placebo‐controlled, phase III trial 20 mg daily oral modified release was conducted 13 sites England Scotland: hospital/community cardiology or palliative...
Objectives To assess the impact of retraction on citation randomized controlled trials. Methods We used an interrupted time-series with matched controls. PubMed, CINHAL, Google and Retraction Watch Database were searched. identified retracted publications reporting results trials involving human participants two years available data before after retraction. obtained monthly counts across all articles for 24 months retraction, from Web Science. a Poisson segmented regression to detect changes...