A5029011020- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Health disparities and outcomes
- Primary Care and Health Outcomes
- Emergency and Acute Care Studies
- Health Policy Implementation Science
- Musculoskeletal pain and rehabilitation
- Cerebral Palsy and Movement Disorders
- Geriatric Care and Nursing Homes
- Healthcare Systems and Technology
- Electronic Health Records Systems
- Balance, Gait, and Falls Prevention
- Nursing Roles and Practices
- Ethics in Clinical Research
- Global Health Workforce Issues
- Clinical practice guidelines implementation
- Alzheimer's disease research and treatments
- COVID-19 and Mental Health
- Frailty in Older Adults
- Mental Health and Patient Involvement
- Health and Medical Research Impacts
- Cardiac, Anesthesia and Surgical Outcomes
- Vitamin K Research Studies
- Healthcare Policy and Management
- Child and Adolescent Psychosocial and Emotional Development
University of York
2014-2024
Royal College of Surgeons of England
2020-2021
Department of Medical Sciences
2011-2021
Barts Health NHS Trust
2021
University Teaching Hospital
2021
Newcastle University
1987-2020
St Thomas' Hospital
2018
Cambridge University Hospitals NHS Foundation Trust
2016
Bradford Teaching Hospitals NHS Foundation Trust
2013
University of Warwick
2013
We describe two extended haplotypes that cover the human tau gene. In a total of ∼200 unrelated caucasian individuals there is complete disequilibrium between polymorphisms which span gene (which covers ∼100 kb DNA). This suggests establishment was an ancient event and either recombination suppressed in this region, or recombinant genes are selected against. Furthermore, we show more common haplotype (H1) significantly over-represented patients with progressive supranuclear palsy (PSP),...
To analyze the association of polymorphisms in tau gene with pathologically confirmed corticobasal degeneration (CBD).The authors previously described an extended haplotype (H1) that covers human and is associated development progressive supranuclear palsy (PSP). The now extend this analysis to CBD, a neurodegenerative condition clinical neuropathologic similarities PSP. Like PSP, CBD accumulation aggregates containing 4-repeat isoforms tau. Because difficulty diagnosis only analyzed cases...
Expanded glutamine repeats of the ataxin-2 (ATXN2) protein cause spinocerebellar ataxia type 2 (SCA2), a rare neurodegenerative disorder. More recent studies have suggested that expanded ATXN2 are genetic risk factor for amyotrophic lateral sclerosis (ALS) via an RNA-dependent interaction with TDP-43. Given phenotypic diversity observed in SCA2 patients, we set out to determine polymorphic nature repeat length across spectrum disorders. In this study, genotyped 3919 disease patients and 4877...
Background Pragmatic trials compare the effects of different decisions in usual clinical practice. Objectives To develop and evaluate methods to implement simple pragmatic using routinely collected electronic health records (EHRs) recruiting patients at point care; identify barriers facilitators for general practitioners (GPs) experiences trial participants. Design Two exemplar randomised (Retropro eLung) with qualitative evaluations. Setting Four hundred fifty-nine English Scottish...
<h3>Importance</h3> There is little evidence to guide management of depressive symptoms in older people. <h3>Objective</h3> To evaluate whether a collaborative care intervention can reduce and prevent more severe depression <h3>Design, Setting, Participants</h3> Randomized clinical trial conducted from May 24, 2011, November 14, 2014, 32 primary centers the United Kingdom among 705 participants aged 65 years or with<i>Diagnostic Statistical Manual Mental Disorders</i>(Fourth Edition)...
Splice-site and missense mutations have been identified in tau associated with frontotemporal dementia parkinsonism linked to chromosome 17. In this study we assessed the genetic contribution of three patient series non-Alzheimer's (non-AD) degenerative dementia. The groups included (1) a community-based from Minnesota, MN; (2) referral clinicopathological tauopathy; (3) pathologically confirmed familial Manchester, UK. Comparing clinical series: stringently diagnosed Manchester series, were...
Background Depression in older adults is common and associated with poor quality of life, increased morbidity early mortality, health social care use. Collaborative care, a low-intensity intervention for depression that shown to be effective working-age adults, has not yet been evaluated people who are managed UK primary care. The CollAborative Screen-Positive EldeRs (CASPER) plus trial fills the evidence gap identified by most recent guidelines on management. Objectives To establish...
Objectives: Multi-method approaches are increasingly advocated in health services research (HSR). This paper examines the use of standardised self-completion questionnaires and questions, during in-depth interviews, a technique termed 'questerviews'. Methods: 'Questerview' techniques were used four empirical studies perceptions conducted by authors. The included both questions or interviews. Respondents tape-recorded while they completed encouraged to discuss their definitions terms...
The aim of our study was to investigate plasma and genetic risk factors for rupture cerebral aneurysms. In London, a case-control made 56 consecutive patients admitted regional neurosurgical service treatment ruptured aneurysm 93 control subjects. A further 40 in Arhus with also were studied. British showed that smoking associated an increased (odds ratio, 9.1; 95% confidence interval [CI], 3.4 23.8; P < .001 history > 10 pack years). After age sex adjustment, included cholesterol...
A large proportion of people living with hip or knee pain do not consult health care professionals. Pain severity is often believed to be the main reason for help seeking in this population; however evidence contradictory. This study explores importance several potential risk factors on across different practitioner groups, among adults chronic a community sample.Health utilization, defined as having seen family doctor (GP) during past 12 months; an allied professional (AHP) alternative...
Research suggests that food intolerance may be a precipitating factor for migraine like headaches.
Background: although maintaining activity is key to successful pain management, and important health wellbeing, it known that older people in frequently alter or reduce levels. A 'fear-avoidance' model often used explain avoidance of the face pain. However, this not intended take account wider context which changes place, nor people's own explanations for their behaviour. Objective: investigate reasons why community adjust levels when living with chronic Methods: thirty-one aged between 67...