A5089561939- Amyotrophic Lateral Sclerosis Research
- Vascular Procedures and Complications
- Peripheral Artery Disease Management
- Nerve injury and regeneration
- Coronary Interventions and Diagnostics
- Aortic aneurysm repair treatments
- Aortic Disease and Treatment Approaches
- Genetic Neurodegenerative Diseases
- Skin and Cellular Biology Research
- Signaling Pathways in Disease
- Hemoglobinopathies and Related Disorders
- Functional Brain Connectivity Studies
- Transcranial Magnetic Stimulation Studies
- Neurological diseases and metabolism
- Muscle activation and electromyography studies
- Mitochondrial Function and Pathology
Beijing Fengtai Hospital
2023
Nanchang University
2014
Nagoya University
1998-1999
Expanded glutamine repeats of the ataxin-2 (ATXN2) protein cause spinocerebellar ataxia type 2 (SCA2), a rare neurodegenerative disorder. More recent studies have suggested that expanded ATXN2 are genetic risk factor for amyotrophic lateral sclerosis (ALS) via an RNA-dependent interaction with TDP-43. Given phenotypic diversity observed in SCA2 patients, we set out to determine polymorphic nature repeat length across spectrum disorders. In this study, genotyped 3919 disease patients and 4877...