A5023392469- Genetic Mapping and Diversity in Plants and Animals
- Fungal and yeast genetics research
- Genetic Associations and Epidemiology
- Genetics, Aging, and Longevity in Model Organisms
- Bioinformatics and Genomic Networks
- Evolution and Genetic Dynamics
- RNA and protein synthesis mechanisms
- CRISPR and Genetic Engineering
- Genomics and Chromatin Dynamics
- Fermentation and Sensory Analysis
- Genomics and Rare Diseases
- Genomics and Phylogenetic Studies
- Gene expression and cancer classification
- Genomic variations and chromosomal abnormalities
- Genetic and phenotypic traits in livestock
- SARS-CoV-2 and COVID-19 Research
- Marine Ecology and Invasive Species
- Chromosomal and Genetic Variations
- Gene Regulatory Network Analysis
- Planarian Biology and Electrostimulation
- Genetics and Neurodevelopmental Disorders
- Circadian rhythm and melatonin
- RNA Research and Splicing
- Genetic Syndromes and Imprinting
- Epigenetics and DNA Methylation
Howard Hughes Medical Institute
2016-2025
University of California, Los Angeles
2016-2025
QB3
2019-2022
Quantitative BioSciences
2019
UCLA Health
2015-2016
Princeton University
2006-2015
Institute for Integrative and Experimental Genomics
2009
Fred Hutch Cancer Center
1999-2006
University of Bamako
2006
Cancer Research Center
2000-2004
Single-nucleotide polymorphisms (SNPs) are the most frequent type of variation in human genome, and they provide powerful tools for a variety medical genetic studies. In large-scale survey SNPs, 2.3 megabases genomic DNA was examined by combination gel-based sequencing high-density variation-detection chips. A total 3241 candidate SNPs were identified. map constructed showing location 2227 these SNPs. Prototype genotyping chips developed that allow simultaneous 500 The results...
To begin to understand the genetic architecture of natural variation in gene expression, we carried out linkage analysis genomewide expression patterns a cross between laboratory strain and wild Saccharomyces cerevisiae. Over 1500 genes were differentially expressed parent strains. Expression levels 570 linked one or more different loci, with most showing complex inheritance patterns. The loci detected by fell largely into two categories: cis-acting modulators single trans-acting many genes....
Inheritance of a defect in neuronal mechanism that regulates response to auditory stimuli was studied nine families with multiple cases schizophrenia. The defect, decrease the normal inhibition P50 auditory-evoked second paired stimuli, is associated attentional disturbances Decreased occurs not only most schizophrenics, but also many their nonschizophrenic relatives, distribution consistent inherited vulnerability for illness. Neurobiological investigations both humans and animal models...
A physical map has been constructed of the human genome containing 15,086 sequence-tagged sites (STSs), with an average spacing 199 kilobases. The project involved assembly a radiation hybrid 6193 loci and incorporated genetic linkage 5264 loci. This information was combined results STS-content screening 10,850 against yeast artificial chromosome library to produce integrated map, anchored by maps. provides coverage 99 percent 94 genome. also represents early step in international generate...
We used molecular markers to study genetic relationships in a diverse collection of 85 domestic dog breeds. Differences among breeds accounted for ∼30% variation. Microsatellite genotypes were correctly assign 99% individual dogs Phylogenetic analysis separated several with ancient origins from the remaining modern European origins. identified four clusters, which predominantly contained similar geographic origin, morphology, or role human activities. These results provide classification and...
Many studies have identified quantitative trait loci (QTLs) that contribute to continuous variation in heritable traits of interest. However, general principles regarding the distribution QTL numbers, effect sizes, and combined effects multiple QTLs remain be elucidated. Here, we characterize complex genetics underlying inheritance thousands transcript levels a cross between two strains Saccharomyces cerevisiae . Most detected weak effects, with median variance explained 27% for highly...
Identifying regions of the human genome that have been targets natural selection will provide important insights into evolutionary history and may facilitate identification complex disease genes. Although signature imparts on DNA sequence variation is difficult to disentangle from effects neutral processes such as population demographic history, selective forces can be distinguished by analyzing multiple loci dispersed throughout genome. We studied molecular evolution 132 genes...