A5102818137- Gut microbiota and health
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Temporomandibular Joint Disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Fungal and yeast genetics research
- Esophageal and GI Pathology
- Orthodontics and Dentofacial Orthopedics
- Oropharyngeal Anatomy and Pathologies
- Metabolomics and Mass Spectrometry Studies
- Genomics and Chromatin Dynamics
- Vitamin D Research Studies
- Cancer, Hypoxia, and Metabolism
- Clostridium difficile and Clostridium perfringens research
- Tracheal and airway disorders
- Folate and B Vitamins Research
- TGF-β signaling in diseases
- Bone health and treatments
- DNA Repair Mechanisms
- RNA Research and Splicing
- Tryptophan and brain disorders
- Drug Transport and Resistance Mechanisms
- Cancer Mechanisms and Therapy
- Esophageal Cancer Research and Treatment
- Bone health and osteoporosis research
Hebei University
2025
Dalian Polytechnic University
2025
Shanghai University of Traditional Chinese Medicine
2017-2024
University of Chinese Academy of Sciences
2024
Second Affiliated Hospital of Zhejiang University
2024
Institute of High Energy Physics
2024
Chinese Academy of Sciences
2024
Zhejiang Lab
2024
Shanghai Institute of Nutrition and Health
2024
Zhengzhou University
2012-2022
A physical map has been constructed of the human genome containing 15,086 sequence-tagged sites (STSs), with an average spacing 199 kilobases. The project involved assembly a radiation hybrid 6193 loci and incorporated genetic linkage 5264 loci. This information was combined results STS-content screening 10,850 against yeast artificial chromosome library to produce integrated map, anchored by maps. provides coverage 99 percent 94 genome. also represents early step in international generate...
A map of 30,181 human gene–based markers was assembled and integrated with the current genetic by radiation hybrid mapping. The new gene contains nearly twice as many genes previous release, includes most that encode proteins known function, is twofold to threefold more accurate than version. redesigned, informative functional World Wide Web site ( www.ncbi.nlm.nih.gov/genemap ) provides mapping information associated data annotations. This resource constitutes an important infrastructure...
The emerging evidence supports the use of prebiotics like herb-derived polysaccharides for treating nonalcoholic fatty liver disease (NAFLD) by modulating gut microbiome. present study was initiated on microbiota-dependent anti-NAFLD effect Astragalus (APS) extracted from mongholicus Bunge in high-fat diet (HFD)-fed mice. However, exact mechanisms underlying beneficial effects APS NAFLD formation remain poorly understood.Co-housing experiment used to assess microbiota dependent APS. Then,...
Accumulating evidence indicates gut microbiota contributes to aging-related disorders. However, the exact mechanism underlying dysbiosis-related pathophysiological changes during aging remains largely unclear. In current study, we first performed remodeling on old mice by fecal transplantation (FMT) from young mice, and then characterized bacteria signature that was specifically altered FMT. Our results revealed FMT significantly improved natural systemic disorders, particularly exerted...
Aging is usually characterized with inflammation and disordered bile acids (BAs) homeostasis, as well gut dysbiosis. The pathophysiological changes during aging are also sexual specific. However, it remains unclear about the modulating process among microbiota, BA metabolism, aging. In this study, we established a direct link between microbiota profile in liver, serum, four intestinal segments of both sexes remodeling by co-housing old mice young ones. We found reduced Actinobacteria male...
Most herbal polysaccharides possess multiple benefits against metabolic disorders, such as non-alcoholic fatty liver disease (NAFLD) and obesity. However, the underlying mechanisms are largely unknown. Here, male C57BL/6J mice were fed with chow or high-fat diet (HFD) without Astragalus (APS) supplementation, gut microbial profile metabolite studied by metagenomic sequencing untargeted metabolomics, respectively. APS was effective in alleviating HFD-induced alteration of microbiota...
Plasminogen activator inhibitor-1 (PAI-1), thrombospondin-1 (THBS1) and thrombomodulin (TM) are involved in atherothrombosis. Vitamin D receptor agonists (VDRAs) provide survival/cardiovascular benefits for chronic kidney disease patients.The effects of VDRAs on regulating PAI-1, THBS1 TM human aortic smooth muscle cells (SMC) endothelial (EC) were studied.In SMC, paricalcitol calcitriol downregulated the expression PAI-1 mRNA protein a dose-dependent manner (EC(50) = 0.7 4.4 nM,...
Cardiac microvascular endothelial cells (CMECs) dysfunction contributes to cardiovascular complications in diabetes, whereas, the underlying mechanism is not fully clarified. FoxO transcription factors are involved apoptosis and reactive oxygen species (ROS) production. Therefore, present study was designed elucidate potential role of FoxO3a on CMECs injury induced by high glucose.CMECs were isolated from hearts adult rats cultured normal or glucose medium for 6 h, 12 h 24 respectively. To...
Amyloid-β (Aβ), the hallmark of Alzheimer's disease (AD), is known to induce reactive oxygen species, peroxynitrite (ONOO-) which plays a crucial role in pathogenesis and progression this incurable disease. However, development tools that can directly detect presence monitor level Aβ-induced ONOO- remains great challenge. We report herein an Aβ synergistically activated NIR fluorescent probe for highly selective imaging vivo. Importantly, responsive exhibits not only strong enhancement...
Vascular calcification is a mortality risk factor for stage 5 chronic kidney disease patients. We investigated the role of phosphorus and vitamin D analogs in pathogenesis vascular using vivo, ex vitro models. Our results demonstrate that uremic rats receiving hyperphosphatemia-inducing diet did not exhibit aortic despite elevated levels serum calcium-phosphorus (CaxP) product. The analog 1α-hydroxyvitamin-D<sub>2</sub> [1α(OH)D<sub>2</sub>] at 0.17 μg/kg raised calcium, phosphorus, CaxP...
TSF3 encodes one of six (TSF1 to TSF6) recently identified global negative regulators transcription in Saccharomyces cerevisiae. Mutant tsf3 strains exhibit defects transcriptional silencing the GAL1 promoter, allow expression from upstream activation sequence-less promoters, and pleiotropic cell growth development. Here we show that is involved mediated by alpha 2 repressor demonstrate specific systems may depend on more role TSF3. Cloning sequencing allowed us predict a 974-amino-acid gene...
Summary Chewing‐side preference ( CSP ) may be associated with temporomandibular disorders. However, little information exists regarding whether will lead to osseous changes of joint TMJ in asymptomatic participants. The aim this study was investigate the relationship between morphology participants and without . Of 121 healthy dentate participants, 35 left , 38 right other 48 were scanned by cone‐beam computed tomography. dimensions reconstructed images opposing s compared. Statistical...
// Cheng-Shi Chen 1 , Fang-Kun Li Chen-Yang Guo Jin-Cheng Xiao Hong-Tao Hu Cheng Lin Zheng Deng-Wei Zong Jun-Li Ma Jiang Hai-Liang Department of Radiology, Zhengzhou University Affiliated Cancer Hospital, 450008, China Correspondence to: Li, e-mail: cjr.lihailiang@vip.163.com Keywords: hepatocellular carcinoma, transarterial chemoembolization, lipiodol, tumor vascularity, overall survival Received: July 23, 2015 Accepted: December 04, Published: January 12, 2016 ABSTRACT This study evaluated...
Bone morphogenetic protein-4 (BMP4) plays a crucial role in carcinogenesis, but the effects and signaling mechanisms of BMP4 hepatocellular carcinoma (HCC) are not clearly clarified. The present study aimed to identify roles proliferation human HCC. In this study, expression its correlation with clinicopathological characteristics survival HCC patients were analyzed two independent cohorts consisting 310 subjects. Functional analysis on was performed vitro vivo specimens, cells Bel-7402...
Gut dysbiosis is heavily involved in the development of various human diseases. There are thousands publications per year for investigating role gut microbiota However, emerging evidence has indicated frequent data inconsistency between different studies, which largely over looked. many factors that can cause variation and during process study, particular, sample storage conditions sequencing process. Here, we systemically evaluated impacts six fecal (three non-commercial protocols, -80 ℃, ℃...