A5046246305- Histone Deacetylase Inhibitors Research
- Synthesis and biological activity
- Microtubule and mitosis dynamics
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- Advanced Nanomaterials in Catalysis
- Crystal structures of chemical compounds
- Cancer Cells and Metastasis
- DNA Repair Mechanisms
- Advanced biosensing and bioanalysis techniques
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- CRISPR and Genetic Engineering
- Peptidase Inhibition and Analysis
- Ferroptosis and cancer prognosis
- TGF-β signaling in diseases
- Electrochemical sensors and biosensors
- Autophagy in Disease and Therapy
- Heat shock proteins research
- Hippo pathway signaling and YAP/TAZ
- Cancer Mechanisms and Therapy
- Organometallic Compounds Synthesis and Characterization
Jining University
2013-2025
Xiyuan Hospital
2025
China Academy of Chinese Medical Sciences
2025
Chengdu University of Traditional Chinese Medicine
2025
Beijing Institute of Neurosurgery
2024
The University of Texas MD Anderson Cancer Center
2022-2024
First Affiliated Hospital of Bengbu Medical College
2024
Shandong Provincial Hospital
2020-2023
Shandong First Medical University
2020-2023
Southwest Medical University
2023
By incorporating histone deacetylase (HDAC) inhibitory functionality into the pharmacophore of epidermal growth factor receptor (EGFR) and human 2 (HER2) inhibitors, we synthesized a novel series compounds with potent, multiacting HDAC, EGFR, HER2 inhibition identified 7-(4-(3-ethynylphenylamino)-7-methoxyquinazolin-6-yloxy)-N-hydroxyheptanamide 8 (CUDC-101) as drug candidate, which is now in clinical development. displays potent vitro activity against an IC(50) 4.4, 2.4, 15.7 nM,...
Abstract Purpose: Given that histone deacetylase (HDAC) inhibitors are known to induce multiple epigenetic modifications affecting signaling networks and act synergistically with phosphatidylinositol 3-kinase (PI3K) inhibitors, we developed a strategy simultaneously inhibit HDACs PI3K in cancer cells. Experimental Design: We constructed dual-acting by incorporating HDAC inhibitory functionality into inhibitor pharmacophore. CUDC-907, development candidate selected from these dual was...
Although immune checkpoint inhibitor (ICI) is regarded as a breakthrough in cancer therapy, only limited fraction of patients benefit from it. Cancer stemness can be the potential culprit ICI resistance, but direct clinical evidence lacking.
Epidemiological studies of mild cognitive impairment (MCI) and subtypes MCI have rarely focused on rural residents in China.This population-based study included 5068 participants (age ≥60 years) who were living communities. We defined MCI, amnestic (aMCI), non-amnestic (naMCI) following the Petersen's criteria that integrated neuropsychological assessments with in-person clinical evaluations.The overall prevalence aMCI, naMCI was 26.48%, 22.30%, 4.18%, respectively. The increased age....
Receptor tyrosine kinase inhibitors have recently become important therapeutics for a variety of cancers. However, due to the heterogeneous and dynamic nature tumors, effectiveness these agents is often hindered by poor response rates acquired drug resistance. To overcome limitations, we created novel small molecule, CUDC-101, which simultaneously inhibits histone deacetylase receptor kinases epidermal growth factor (EGFR) human 2 (HER2) in cancer cells. Because its integrated inhibition,...
Abstract Purpose: We designed and synthesized CUDC-305, an HSP90 inhibitor of the novel imidazopyridine class. Here, we report its unique pharmacologic properties antitumor activities in a variety tumor types. Experimental Design: The potency compound was analyzed by fluorescence polarization competition binding assay. Its antiproliferative were assessed 40 human cancer cell lines. evaluated xenograft models. Results: CUDC-305 shows high affinity for HSP90α/β (IC50, ∼100 nmol/L) complex...
Abstract Tumor invasion and chemotherapy resistance, which are associated with epithelial-mesenchymal transition (EMT), remain as major challenges in hepatocellular carcinoma (HCC) treatment. Neferine, a natural component of Nelumbo nucifera, have been proven the antitumor efficiency cancer, but effects Neferine on HCC chemosensitivity need to be elucidated. Applying multiple assays cell proliferation, flow cytometry, immunofluorescence staining, qRT-PCR, Western blot, fluorescence molecular...
Abstract Activation of autophagy significantly affects cancer cell behaviors, such as proliferation, differentiation, and invasiveness. Epithelial‐to‐mesenchymal transition (EMT) an initial step malignant transformation cells was linked to the activation autophagy, but detailed molecular mechanisms are still unknown. The present study investigates effects Beclin‐1, a key molecule involved in on EMT colon cells. normal epithelia line CCD‐18Co six lines with different expression levels...
Autophagy is a conserved catabolic process with complicated roles in tumor development. Bone morphogenetic protein 4 (BMP4), member of the transforming growth factor (TGF-β) family regulatory proteins, plays crucial role human malignancies. However, whether BMP4 contributes to regulation autophagy hepatocellular carcinoma (HCC) progression remains elusive.Functional analysis on HCC proliferation and was performed both vitro vivo HepG2 HCCLM3 cells. Autophagic activity estimated by Western...
Purpose: It remains unclear that long noncoding RNAs' role in cancer initiation and progression, including osteosarcoma. Long RNA LINC00963 was found to be participated carcinogenesis progression of However, the molecular mechanisms engaged osteosarcoma (OS) still needs explored.Methods: miR-204-3p expression levels were quantified by PCR OS tissues cells. CCK 8 assay, wound healing assay transwell migration invasion chosen assess cell growth, viability, migration, invasion. Luciferase...
Developing a new cost-effective and reliable approach used for the detection of uric acid (UA) with no requirement uricase is still very challenging. Herein, an easily realized, cost-effective, uricase-free reported selective colorimetric biosensing UA utilizing polypyrrole (PPy)-coated polyoxometalate-encapsulated fourfold helical metal-organic frameworks Ag5[bimt]2[PMo12O40]·2H2O (Ag5PMo12) as monolithic peroxidase mimic. It demonstrated that as-obtained Ag5PMo12@PPy possesses excellent...
Abstract CUDC-305 is a heat shock protein 90 (HSP90) inhibitor of the novel imidazopyridine class. Here, we report its activities in non–small cell lung cancer (NSCLC) lines with gene deregulations conferring primary or secondary resistance to epidermal growth factor receptor (EGFR) inhibitors. We show that binds strongly HSP90 extracted from erlotinib-resistant NSCLC cells (IC50 70 nmol/L). This result correlates well potent antiproliferative activity 120–700 nmol/L) reported previously....
To explore the effect of cognitive behavioral therapy (CBT) in combination with systemic family (SFT) on mild to moderate postpartum depression and sleep quality.249 primiparous women were recruited randomly assigned a control group (n=128), which received conventional care, or psychological intervention (n=121), care combined intervention. The Edinburgh Postnatal Depression Scale (EPDS) Pittsburgh Sleep Quality Index (PSQI) employed evaluate quality, respectively.104 patients 109 completed...
Background: Oxaliplatin (OXA) chemotherapy is widely used in the clinical treatment of colon cancer. However, chemo-resistance still a barrier to effective cases Accumulated evidence suggests that epithelial mesenchymal transition (EMT) may be critical factor chemo-sensitivity. The present study investigated effects Zinc finger E-box binding homeobox 1 (ZEB1) on OXA-sensitivity cancer cells. Method: ZEB1expression and its correlation with clinicopathological characteristics were analyzed...
Background: Chemoresistance is a major obstacle to improving the survival rate of colorectal cancer (CRC) patients. Forkhead box protein C2 (FOXC2), member forkhead (Fox) transcription factor family, reported be an important regulator epithelial-to-mesenchymal transition (EMT) and plays key role in tumor progression. However, little known about effects FOXC2 on oxaliplatin (OXA) resistance CRC. Methods: OXA-resistant cells were generated from HCT116 cells. CCK-8, colony formation, flow...
Cell surface proteins play essential roles in various biological processes and are highly related to cancer development. They also serve as important markers for cell identity targets pharmacological intervention. Despite their great potentials biomedical research, comprehensive functional analysis of remains scarce. Here, with a de novo designed library targeting proteins, we performed vivo CRISPR screens evaluate the effects on tumor survival proliferation. We found that Kirrel1 loss...
This study aimed to explore the knowledge, attitude, and practice (KAP) concerning anterior cruciate ligament (ACL) injuries among youth. cross-sectional was conducted at Hospital of Chengdu University TCM between January 2024 March 2024, included youth aged from 18 39 years old. Demographic characteristics KAP scores were collected via self-administered questionnaires. A total 561 valid questionnaires analyzed. Of these, 292 respondents (52.05 %) female, 317 (56.51 had experienced ACL or...