A5101219450- Immune Response and Inflammation
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Musculoskeletal synovial abnormalities and treatments
- Antimicrobial Resistance in Staphylococcus
- Immune Cell Function and Interaction
- COVID-19 Impact on Reproduction
- Knee injuries and reconstruction techniques
- Cancer-related molecular mechanisms research
- Pharmacogenetics and Drug Metabolism
- MicroRNA in disease regulation
- Folate and B Vitamins Research
- Pluripotent Stem Cells Research
- HIV/AIDS drug development and treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Blood groups and transfusion
- Reproductive System and Pregnancy
- Antimicrobial Peptides and Activities
- Renal Transplantation Outcomes and Treatments
- Biochemical and Molecular Research
- Chemokine receptors and signaling
- Tendon Structure and Treatment
- Pregnancy and Medication Impact
- Glioma Diagnosis and Treatment
- Genetics and Neurodevelopmental Disorders
Children's Hospital of Capital Institute of Pediatrics
2023-2025
Nanfang Hospital
2023-2024
Hangzhou Medical College
2024
Zhejiang Provincial People's Hospital
2024
Southern Medical University
2023-2024
Pudong New Area People's Hospital
2023
Shandong Tumor Hospital
2023
Zhengzhou University
2023
Shandong First Medical University
2023
Shanghai Medical College of Fudan University
2007
<title>Abstract</title> Combined methylmalonic acidemia and homocystinemia (cblC) is an autosomal recessive disorder characterized by aberrant organic acid metabolism. The c.80A > G mutation in the <italic>MMACHC</italic> gene has been documented numerous studies linked to cblC phenotypes. However, this mutation's pathogenic mechanisms remain elusive, as it not yet validated through functional studies. In a previous study, we developed murine model with Mmachc elucidate intricacies of...
<title>Abstract</title> Combined methylmalonic acidemia and homocystinemia (cblC) is an autosomal recessive disorder characterized by aberrant organic acid metabolism. The c.80A > G mutation in the <italic>MMACHC</italic> gene has been documented numerous studies linked to cblC phenotypes. However, this mutation's pathogenic mechanisms remain elusive, as it not yet validated through functional studies. In a previous study, we developed murine model with Mmachc elucidate intricacies of...
Th1-type immune cytokines are essential to establish adaptive immunity against various microbial pathogens, including Escherichia coli, which cause most urinary tract infections (UTIs). Dendritic cells (DCs) vital initiate Th1 immunity, while neutrophils, also referred here as polymorphonuclear leukocytes (PMN) reported be involved in initiation by secreting several chemokines and cytokines. We found that lipopolysaccharide (LPS)-triggered PMN (LPS-PMN) vitro induced strong up-regulation of...
Tendons serve as important weight-bearing structures that smoothly transfer forces from muscles to skeletal parts, allowing contracted muscle movements be translated into corresponding joint movements. For body mechanics, tendon tissue plays an role. If the tendons are damaged varying degrees, it can lead disability or pain in patients. That is say, injuries havea significant impact on quality of life and deserve our high attention. Compared other musculoskeletal tissues, hypovascular...
Abstract Mycophenolic acid (MPA) is commonly used to treat autoimmune diseases in children, and therapeutic drug monitoring recommended ensure adequate exposure. However, multiple blood sampling required calculate the area under plasma concentration‐time curve (AUC), causing patient discomfort waste of human financial resources. This study aims use machine learning deep algorithms develop a prediction model MPA exposure for pediatric with optimizing frequency. Pediatric patients' data were...
Background: Numerous studies have highlighted the crucial role of G protein-coupled receptors (GPCRs) in tumor microenvironment (TME) remodeling and their correlation with progression. However, association between GPCRs TME glioblastoma (GBM) remains largely unexplored. Methods: In this study, we investigated expression profile GBM using integrated data from single-cell RNA sequencing bulk sequencing. Surgical samples obtained meningioma patients underwent to examine GPCR levels cell-cell...
OBJECTIVE To investigate whether polymorphonuclear neutrophilic leucocyte (PMN) can induce the maturation and activation of immature dendritic cells, thus promoting Th1 immunity to microbial pathogens in vitro. METHODS PMN isolated from mouse bone marrow were stimulated by lipopolysaccharide (LPS), cultured with DC (imDCs) for 18 hours. Then analysis surface markers CD40 CD86 was done flow cytometry, ELISA used detect levels TNF-alpha IL-12. Purified cocultured LPS-PMN (PMN-DC) imDC...
The DEPDC5 gene (OMIM 614191) has been proven to be a frequent cause of familial and sporadic focal epilepsy. A human induced pluripotent stem cell (iPSC) line was generated from child diagnosed with epilepsy, which caused by DEDPC5 mutation. iPSC expresses high pluripotency markers, carries the mutation, can differentiate into three germ layers in vitro. lines offer promising technique for studying pathogenesis conducting drug screening DEDPC5-related