A5073535992- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Genomics and Rare Diseases
- CRISPR and Genetic Engineering
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Bioinformatics and Genomic Networks
- Genetics and Neurodevelopmental Disorders
- Genetic Associations and Epidemiology
- Bone Metabolism and Diseases
- interferon and immune responses
- RNA Research and Splicing
- Neurological and metabolic disorders
- Genetic Syndromes and Imprinting
- Polyomavirus and related diseases
- Autophagy in Disease and Therapy
- Parkinson's Disease Mechanisms and Treatments
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- Neurological diseases and metabolism
Central South University
2018-2023
Second Xiangya Hospital of Central South University
2021-2023
Xiangya Hospital Central South University
2022-2023
SUNY Upstate Medical University
2021-2023
Laboratoire de Génétique Médicale
2021
Hunan Normal University
2017
POU3F2 regulates expression of key genes in postmortem brain tissue from patients with schizophrenia or bipolar disorder.
Genome-wide association studies (GWASs) have been successful in identifying loci associated with osteoporosis and obesity. However, the findings explain only a small fraction of total genetic variance.The aim this study was to identify novel pleiotropic genes important obesity.A conditional false discovery rate method applied three independent GWAS summary statistics femoral neck bone mineral density, body mass index, waist-to-hip ratio. Next, differential expression analysis performed for...
Abstract Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and aging genetic environmental exposure can contribute to its pathogenesis. DNA methylation has been suggested play a pivotal role in neurodevelopment diseases. 5-hydroxymethylcytosine (5hmC) generated through 5-methylcytosine (5mC) oxidization by ten-eleven translocation proteins particularly enriched brain. Although 5hmC linked multiple neurological disorders, little known about alterations substantia...
Abstract Background and Hypothesis Viral infections are increasingly recognized in the etiology of psychiatric disorders based on epidemiological serological studies. Few studies have analyzed viruses directly within brain no comprehensive investigation viral infection diseased brains has been completed. This study aims to determine whether tissues is a risk factor for 3 major disorders, including schizophrenia, bipolar disorder, autism spectrum disorder. Study Design evaluated presence DNA...