A5087465807- Neuroscience and Neuropharmacology Research
- Neural dynamics and brain function
- Neuroscience and Neural Engineering
- Photoreceptor and optogenetics research
- Memory and Neural Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Molecular Communication and Nanonetworks
- Zebrafish Biomedical Research Applications
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Sleep and Wakefulness Research
- Genetics and Neurodevelopmental Disorders
- Stress Responses and Cortisol
- Advanced Fluorescence Microscopy Techniques
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
Daegu Gyeongbuk Institute of Science and Technology
2021-2025
Johns Hopkins Medicine
2021-2023
Johns Hopkins University
2021-2023
Max Planck Florida Institute for Neuroscience
2017-2023
Seoul National University
2019-2021
New Generation University College
2020
Seoul National University Hospital
2013-2015
Abstract Verifying causal effects of neural circuits is essential for proving a direct circuit-behavior relationship. However, techniques tagging only active neurons with high spatiotemporal precision remain at the beginning stages. Here we develop soma-targeted Cal-Light (ST-Cal-Light) which selectively converts somatic calcium rise triggered by action potentials into gene expression. Such modification simultaneously increases signal-to-noise ratio reporter expression and reduces light...
Cognitive flexibility is a brain's ability to switch between different rules or action plans depending on the context. However, cellular level understanding of cognitive have been largely unexplored. We probed specific serotonergic pathway from dorsal raphe nuclei (DRN) orbitofrontal cortex (OFC) while animals are performing reversal learning task. found that serotonin release DRN OFC promotes learning. A long-range connection these two brain regions was confirmed anatomically and...
<title>Abstract</title> The hippocampus forms memories of our experiences by registering processed sensory information in coactive populations excitatory principal cells or ensembles. Fast-spiking parvalbumin-expressing inhibitory neurons (PV INs) the dentate gyrus (DG)-CA3/CA2 circuit contribute to memory encoding exerting precise temporal control cell activity through mossy fiber-dependent feed-forward inhibition. PV INs respond input-specific coordinating changes their intrinsic...
The intrinsic excitability of neurons plays a critical role in the encoding memory at Hebbian synapses and coupling synaptic inputs to spike generation. It has not been studied whether somatic firing physiologically relevant frequency can induce plasticity hippocampal CA3 pyramidal cells (CA3-PCs). Here, we show that conditioning train 20 action potentials (APs) 10 Hz causes persistent reduction input conductance an acceleration AP onset time CA3-PCs, but CA1-PCs. Induction such long-term...
IgSF11 homophilic cell adhesion molecules regulate the synaptic laminar specificity of cortical chandelier cells.
Key points We investigated the cellular mechanisms underlying mossy fibre‐induced heterosynaptic long‐term potentiation of perforant path (PP) inputs to CA3 pyramidal cells. Here we show that this is mediated by downregulation Kv1.2 channels. The preferentially enhanced PP‐evoked EPSPs which occur at distal apical dendrites. Such enhancement PP‐EPSPs required activation dendritic Na + channels, and its threshold was lowered Kv1.2. Our results may provide new insights into long‐standing...
Observing the activity of neural networks is critical for identification learning and memory processes, as well abnormal activities circuits in disease, particularly purpose tracking disease progression. Methodologies describing history using molecular biology techniques first utilized genes expressed by active neurons, followed application recently developed including optogenetics incorporation insights garnered from other disciplines, chemistry physics. In this review, we will discuss ways...
Repetitive action potentials (APs) in hippocampal CA3 pyramidal cells (CA3-PCs) backpropagate to distal apical dendrites, and induce calcium protein tyrosine kinase (PTK)-dependent downregulation of Kv1.2, resulting long-term potentiation direct cortical inputs intrinsic excitability (LTP-IE). When APs were elicited by somatic stimulation CA3-PCs from rodents either sex, only a narrow window dendritic [Ca 2+ ] allowed LTP-IE because Ca -dependent coactivation PTK phosphatase (PTP), which...
Abstract The associative network of hippocampal CA3 is thought to contribute rapid formation contextual memory from one‐trial learning, but the mechanisms underlying decorrelation neuronal ensembles in largely unknown. Kv1.2 expressions rodent pyramidal cells (CA3‐PCs) are polarized distal apical dendrites, and its downregulation specifically enhances dendritic responses perforant pathway (PP) synaptic inputs. We found that haploinsufficiency ( Kcna2 +/−) CA3‐PCs, not Kv1.1 Kcna1 +/−),...
Abstract Verifying causal effects of neural circuits is essential for proving direct a circuit-behavior relationship. However, techniques tagging only active neurons with high spatiotemporal precision remain at the beginning stages. Here we developed soma-targeted Cal-Light (ST-Cal-Light) which selectively converts somatic calcium rise triggered by action potentials into gene expression. Such modification simultaneously increases signal-to-noise ratio (SNR) reporter expression and reduces...
Abstract Kv1.2 expression in rodent CA3 pyramidal cells (CA3-PC) is polarized to distal apical dendrites, and regulate the synaptic responses perforant pathway (PP) inputs. Accordingly, haploinsufficiency ( Kcna2 +/−) CA3-PCs, but not Kv1.1 Kcna1 +/−), lowered threshold for long-term potentiation at PP-CA3 synapses. The +/− mice, +/−, displayed impairments contextual fear discrimination task. size overlap of ensembles activated by first visits slightly different contexts were between...