A5026121160- Neurogenesis and neuroplasticity mechanisms
- Epigenetics and DNA Methylation
- Stress Responses and Cortisol
- Neuroscience and Neuropharmacology Research
- MicroRNA in disease regulation
- Genomics and Chromatin Dynamics
- Gallbladder and Bile Duct Disorders
- Developmental Biology and Gene Regulation
- Planarian Biology and Electrostimulation
- Neuroscience and Neural Engineering
- Pharmacological Effects of Natural Compounds
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Pancreatic and Hepatic Oncology Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Hedgehog Signaling Pathway Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Marine Ecology and Invasive Species
- Lysosomal Storage Disorders Research
- Zebrafish Biomedical Research Applications
- Neural dynamics and brain function
- Management of metastatic bone disease
- Tryptophan and brain disorders
- Genetics and Neurodevelopmental Disorders
- Single-cell and spatial transcriptomics
- Plant-derived Lignans Synthesis and Bioactivity
Yokohama City University Medical Center
2024-2025
Yokohama City University
2024-2025
Kindai University
2018-2024
Osaka University
2024
Max Planck Florida Institute for Neuroscience
2017-2021
Yokohama Minami Kyosai Hospital
2021
Institute of Natural Science
2017
National Institute for Physiological Sciences
2008-2017
National Institutes of Natural Sciences
2008-2017
The Graduate University for Advanced Studies, SOKENDAI
2010-2015
Background/Objectives: Detective flow imaging (DFI) endoscopic ultrasonography (EUS) can identify the microvascular of a mural nodule (MN) in an intraductal papillary mucinous neoplasm (IPMN) without use contrast agents. This retrospective study evaluated diagnostic accuracy DFI-EUS and its ability to evaluate blood MNs IPMNs. Methods: Between April 2021 September 2023, 68 patients with IPMNs observed on EUS images were retrospectively analyzed. Both contrast-enhanced (CE-EUS) performed...
Covered self-expandable metal stents (cSEMS) are commonly used to treat malignant distal biliary obstruction (MDBO) [1]; however, they can lead cholecystitis [2] [3]. A novel stent – the HILZO dumbbell-shaped with spiral cover (ABIS Inc., Hyogo, Japan) was designed prevent stent-related [4]. The proximal end creates space around orifice of cystic duct (OCD), while outer facilitates bile flow ([Fig. 1], [Fig. 2]). Herein, we report two cases MDBO in which cSEMS placed beyond OCD ([Video 1]).
Oligodendrocyte precursor cells (OPCs) appear in the late embryonic brain, mature to become oligodendrocytes (OLs), and form myelin postnatal brain. Recently, it has been proposed that early-born OPCs derived from ventral forebrain are eradicated postnatally late-born OLs predominate cortex of adult mouse However, intrinsic extrinsic factors specify ability self-renewing multipotent neural stem brain generate cortical OL-lineage remain largely unknown. Using an inducible Cre/loxP system...
Diverse types of cortical interneurons (INs) mediate various kinds inhibitory control mechanisms to balance and shape network activity. Distinct IN subtypes develop uniquely organized axonal arbors that innervate different subcellular compartments excitatory principal neurons (PNs), which critically contribute determining their output properties. However, it remains poorly understood how they establish this peculiar organization synaptic connectivity during development. Here, taking...
Females are well known to suffer disproportionately more than males from stress-related neuropsychiatric disorders, especially during perimenopausal and postmenopausal periods. In addition a decline in serum estradiol levels, environmental stress social likely contribute the development of symptoms women. Kamishoyosan (KSS) is traditional Japanese Kampo medicine, composed specified mixture 10 crude compounds derived plant sources, widely used for various However, molecular mechanisms...
IgSF11 homophilic cell adhesion molecules regulate the synaptic laminar specificity of cortical chandelier cells.
Different cortical regions processing distinct information, such as the hippocampus and neocortex, share common cellular components circuit motifs but form unique networks by modifying these cardinal units. Cortical circuits include diverse types of GABAergic interneurons (INs) that shape activity excitatory principal neurons (PNs). Canonical IN conserved across have been defined their morphological, electrophysiological, neurochemical properties. However, it remains largely unknown whether...
Cell cycle regulation is crucial for the maintenance of stem cell populations in adult mammalian tissues. During development, length neural cells increases, which could be associated with their capabilities self-renewal. However, molecular mechanisms that regulate differentiation and progression embryonic remain largely unknown. Here, we investigated function Bre1a, a histone H2B ubiquitylation factor, expressed most but not all precursor (NPCs) developing mouse brain. We found knockdown...
Sulfatases (Sulfs) are a group of endosulfatases consisting Sulf1 and Sulf2, which specifically remove sulfate from heparan proteoglycans. Although several studies have shown that acts as regulator sonic hedgehog (Shh) signaling during embryonic ventral spinal cord development, the detailed expression pattern function Sulf2 in remains to be determined. In this study, we found also modulates cell fate change motor neurons (MNs) oligodendrocyte precursor cells (OPCs) by regulating Shh mouse...
Covered self-expandable metallic stent (SEMS) placement is effective for malignant distal biliary obstruction [1]; however, it carries the risk of cholecystitis, pancreatitis, and migration [2] [3] [4]. The novel HILZO dumbbell-shaped, spiral cover (ABIS Inc., Hyogo, Japan) has a unique structure that prevents such complications ([Fig. 1]). dumbbell-shaped proximal end migration. belt-like gap in outer helps bile pancreatic juice flow out, whereas inner full tumor growth. Herein, we report...
Protein arginine methylation has been recognized as one of key posttranslational modifications for refined protein functions, mediated by methyltransferases (Prmts). Coactivator-associated methyltransferase (Carm1, also known Prmt4) participates in various cellular events, such cell survival, proliferation, and differentiation through its activities. Carm1 regulates proliferation a neuronal line is reportedly expressed the mammalian brain. However, detailed function central nervous system,...
Oligodendrocytes, the myelin-forming cells in central nervous system (CNS), undergo morphological differentiation characterized by elaborated branched processes to enwrap neuronal axons. However, basic molecular mechanisms underlying oligodendrocyte morphogenesis remain unknown. Herein, we describe essential roles of Nuclear Distribution E Homolog 1 (NDE1), a dynein cofactor, differentiation. In mouse corpus callosum, Nde1 mRNA expression was detected lineage at postnatal stage. vitro...
Planarian species may harbor as many three populations with different reproductive strategies. Animals from innate asexual (AS) and sexual (InS) reproduce only by fission cross-fertilization, respectively, whereas the third population switches seasonally between two modes. AS worms can be experimentally sexualized feeding them minced InS worms; we termed resulting animals "acquired sexual" (AqS) worms. Both AqS exhibit sexualizing activity when used feed, suggesting that they maintain their...
Planarians are well known for their remarkable regenerative capacity. This capacity to regenerate is thought be due the presence of totipotent somatic stem cells as 'neoblasts', which have particular morphological characteristics. The totipotency neoblasts was supported by Baguñà's experiment, involved introduction donor into irradiated hosts. However, since experiment did not include use a phenotypic marker, could traced. In current study, genetic mutant planarian, menashi, an eye-defective...
CRISPR/Cas-based technologies have revolutionized genetic approaches to addressing a wide range of neurobiological questions. The ability CRISPR/Cas introduce mutations into target genes allows us perform in vivo loss-of-function experiments without generating genetically engineered mice. However, the lack reliable method determine genotypes individual CRISPR/Cas-transfected cells has made it impossible unambiguously identify cause their phenotypes vivo. Here, we report strategy for...
Objective: Kamishoyosan (KSS), a traditional Japanese Kampo medicine, is widely used to treat neuropsychiatric symptoms in perimenopausal and postmenopausal women. We aimed elucidate the functional mechanisms underlying KSS-mediated reduction of stress response behaviors neuropsychological Methods: Female mice were bilaterally ovariectomized (OVX) at age 12 weeks exposed chronic water immersion restraint for three weeks. Among them, OVX+stress+KSS group fed chow containing KSS from one week...
Pancreatic stent placement is suggested after endoscopic papillectomy [1] [2]; however, there a risk of pancreatic duct injury during guidewire manipulation. Endoscopic ultrasound-guided drainage (EUS-PDD) can be an alternative technique failed retrograde pancreatography [3] [4].