A5000442164- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Air Quality and Health Impacts
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Inflammasome and immune disorders
- Kawasaki Disease and Coronary Complications
- Heparin-Induced Thrombocytopenia and Thrombosis
- Antiplatelet Therapy and Cardiovascular Diseases
- Galectins and Cancer Biology
- Coronary Artery Anomalies
- Acute Myocardial Infarction Research
- Ion Channels and Receptors
- RNA modifications and cancer
- Cardiovascular Issues in Pregnancy
- Ferroptosis and cancer prognosis
- Sepsis Diagnosis and Treatment
- Immune Response and Inflammation
Guangzhou Medical University
2019-2024
First Affiliated Hospital of Guangzhou Medical University
2022-2024
Guangzhou Women and Children Medical Center
2022
State Key Laboratory of Respiratory Disease
2022
Lung cancer has high morbidity and mortality worldwide with non-small cell lung (NSCLC) accounting for 85% of the cases. Therapies have relatively poor outcomes further improvements are required. Circular RNAs been reported to participate in occurrence progression cancer. Information on functions mechanism circRNAs is limited needs more exploration. We detected expression genes proteins by qPCR western blot. Function circSATB2 was investigated using RNA interference overexpression assays....
Fine particulate matter (PM2.5) is one of the most important components environmental pollutants, and associated with pulmonary injury. However, biological mechanisms damage caused by PM2.5 are poorly defined, especially molecular pathways related to inflammation. Following system exposure for 3 months in normal mice chronic obstructive disease (COPD) model mice, it was found that increased expression IL-1β IL-18 lung tissues via NLRP3 activation, these effects were more intense COPD mice....
Fine particulate matter (PM2.5) has been verified to augmented the incidence of pneumonia, asthma, pulmonary fibrosis, and other diseases. Airway inflammation is pathological basis respiratory system, understanding molecular mechanisms responsible for airway may thus support diagnosis treatment In our study, human bronchial epithelial cells (BEAS-2B) were exposed various concentrations PM2.5 48 h. entered cells, resulting in increased production interleukin 6 (IL-6) 8 (IL-8) decreased...
Inhalation of carbon black nanoparticles (CBNPs) can impair lung tissue and cause DNA damage, but the epigenetic mechanism responsible for these effects is still unclear. We explored role circular RNAs (circRNAs) in damage induced by CBNPs lung. Human bronchial epithelial cell lines (16HBE BEAS-2B) were treated with 0, 5, 10, 20, 40, or 80 μg/ml 24, 48, 72 h, BALB/c mice exposed to 8 μg/d 14 days establish vitro vivo models CBNP exposure, respectively. found that caused double-strand breaks...
Benzo[a]pyrene (B[a]P) is a class I carcinogen and hazardous environmental pollutant with genetic toxicity. Understanding the molecular mechanisms underlying deterioration epigenetic alterations induced by contaminants may contribute to early detection prevention of cancer. However, role regulatory circular RNAs (circRNAs) in B[a]P-induced DNA damage response (DDR) have not been elucidated. In this study, human bronchial epithelial cell lines (16HBE BEAS-2B) were exposed various...
Kawasaki disease (KD) is an acute vasculitis that may result in permanent coronary artery damage with unknown etiology. Endothelial cell (EC) dysfunction and platelet hyperactivity are the hallmarks of KD. Platelets involved development endothelial dysfunction. MiR-223 transferred by microparticles (PMPs) has been found to involve functional regulation cells sepsis. However, role platelet-derived miR-223 not yet investigated We seek investigate KD vasculopathy. Forty-five patients 45 matched...
TRPM2 (transient receptor potential melastatin-2), a Ca2+ permeable, non-selective cation channel, is highly expressed in cancers and regulates tumor cell migration, invasion, proliferation. However, no study has yet demonstrated the association of with prognosis cancer patients or immune infiltration, possibility clinical basis as prognostic marker are unknown. In current study, we first explored correlation between mRNA level different across public databases. Subsequently, Tumor Immune...
Abstract Increasing environmental genotoxic chemicals have been shown to induce epigenetic alterations. However, the interaction between genetics and epigenetics in chemical carcinogenesis is still not fully understood. Here, we constructed an vitro human lung model (16HBE-T) by treating bronchial epithelial cells with a typical significant carcinogen benzo(a)pyrene (BaP). We identified novel circular RNA, circ0087385, which was overexpressed 16HBE-T cancer cell lines, as well tissues serum...
Abstract Dysregulated inflammation is closely associated with increased mortality in sepsis. Platelets have emerged as key inflammatory cells implicated the pathology of sepsis, including development thrombosis, thrombocytopenia, and neutrophil extracellular traps (NETs). Platelet’s contributions to rapid clinical deterioration dysregulated sepsis not been defined. In our cohort, incidence thrombocytopathy excessive cytokines released patients severe were significantly increased. Platelet...