A5051963524- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Adipokines, Inflammation, and Metabolic Diseases
- Autoimmune and Inflammatory Disorders Research
- Systemic Sclerosis and Related Diseases
- Cytokine Signaling Pathways and Interactions
- Chronic Lymphocytic Leukemia Research
- T-cell and B-cell Immunology
- Gestational Diabetes Research and Management
- Immunodeficiency and Autoimmune Disorders
- Mesenchymal stem cell research
- Immune Cell Function and Interaction
- Vitamin D Research Studies
- Cardiac Imaging and Diagnostics
- Viral Infections and Immunology Research
- Bone Metabolism and Diseases
- Vitamin C and Antioxidants Research
- Atherosclerosis and Cardiovascular Diseases
- Metabolism, Diabetes, and Cancer
- Bone health and treatments
- Hematopoietic Stem Cell Transplantation
- Cancer-related gene regulation
- Mast cells and histamine
Nazarbayev University
2022-2024
NIHR Leeds Musculoskeletal Biomedical Research Unit
2014-2023
University of Leeds
2014-2023
Leeds Teaching Hospitals NHS Trust
2014-2023
National Institute for Health Research
2020-2021
University of Pisa
2021
Chapel Allerton Hospital
2015-2020
St James's University Hospital
2014-2018
Laboratoire d'Informatique, de Robotique et de Microélectronique de Montpellier
2017
Medical University of Lublin
2011-2013
Uncultured mesenchymal stromal cells (MSCs) are increasingly used in therapies; however, the effects of donor age on their biological characteristics and gene expression remain unclear. The aim this study was to investigate age-related changes bone marrow (BM) MSCs following minimal or no culture manipulation. Iliac crest BM aspirated from 67 healthy donors (19-89 years old) directly for colony-forming unit-fibroblast (CFU-F) assay CD45lowCD271+ cell enumeration. colonies were analysed...
Type I interferons (IFN-Is) play a role in broad range of rheumatic and musculoskeletal diseases (RMDs), compelling evidence suggests that their measurement could have clinical value, although testing has not progressed into settings. To develop evidence-based points to consider (PtC) for the reporting IFN-I assays research determine potential utility. EULAR standardised operating procedures were followed. A task force including rheumatologists, immunologists, translational scientists...
Anticitrullinated protein antibody (ACPA)+ individuals with non-specific musculoskeletal symptoms are at risk of inflammatory arthritis (IA). This study aims to demonstrate the predictive value T cell subset quantification for progression towards IA and compare it previously identified clinical predictors progression.103 ACPA+ without synovitis were observed 3-monthly 12 months then as clinically indicated. The end point was development IA. Naïve, regulatory cells (Treg) inflammation related...
<h3>Objectives</h3> The therapeutic goal for patients with rheumatoid arthritis (RA) is clinical remission. This best achieved by early diagnosis and appropriate intervention. RA associated dysregulation of T-cell subsets (naïve, regulatory (Treg) inflammation-related cells (IRC)) in the disease. Our aim was to test hypothesis that subset quantification can predict achievement remission treatment RA. <h3>Methods</h3> were quantified 108 drug-naïve, commencing methotrexate (MTX) or...
Abstract The presence of a disease continuum in inflammatory arthritis (IA) is recognised concept, with distinct stages from at-risk stage (presence anti citrullinated-peptide autoantibody) to diagnosis rheumatoid (RA), including therapy-induced remission. Despite T-cell dysregulation being key feature RA, there are few reports phenotyping along the IA-continuum. We investigated disturbances naïve, regulatory and inflammation related cell (IRC) CD4+ subsets 705 individuals across...
To screen for significant arrhythmias with an implantable loop recorder (ILR) in patients SSc and no known cardiovascular disease, identify associated disease phenotype, blood magnetic resonance (CMR) biomarkers.Twenty history of primary heart traditional diabetes or maximum one risk factor underwent clinical assessment, contrast-enhanced CMR ILR insertion.ILR data were available 19 patients: 63% female, mean (s.d.) age 53 (12) years, 32% diffuse SSc. Eight had over 3 years: complete block,...
In a cross-sectional study, we evaluated the prevalence of 'multi-dimensional remission' (MDR) and its component parameters, assessed using objective measures in cohort RA patients treatment-induced DAS28-remission, their relationship with patient-reported outcome measures. We sought to confirm feasibility face validity MDR construct, providing platform for future longitudinal studies which clinical utility might be further established.605 were selected from an inflammatory arthritis...
Abstract Objectives SSc primary heart involvement (SSc-pHI) is a significant cause of mortality. We aimed to characterize and identify predictors subclinical SSc-pHI using cardiovascular MRI. Methods A total 83 patients with no history disease or pulmonary arterial hypertension 44 healthy controls (HCs) underwent 3 Tesla contrast-enhanced MRI, including T1 mapping quantitative stress perfusion. High-sensitivity troponin I N-terminal pro-brain natriuretic peptide were also measured. Results...
Objectives To explore the prognostic value of subclinical cardiovascular (CV) imaging measures and serum cardiac biomarkers in systemic sclerosis (SSc) for development CV outcomes primary heart involvement (pHI). Methods Patients with SSc no clinical SSc-pHI history disease underwent magnetic resonance (CMR) imaging, measurement high-sensitivity-troponin I (hs-TnI) N-terminal-pro-brain natriuretic peptide (NT-proBNP). Follow-up outcome data were recorded. defined as myocarditis, arrhythmia...
Serum resistin concentration is increased in patients with nonalcoholic fatty liver disease proportion the histological severity of disease, but relevance contribution per se undetermined.The objective study was to assess relationship between serum and degree ectopic fat accumulation vivo humans.The hepatic (IHF) content, measured quantitatively by means 1H magnetic resonance spectroscopy, resistin, biochemical hormonal metabolic correlates insulin resistance were assessed 28 affected...
Objectives. To determine the change in established biomarkers of cardiovascular (CV) risk, namely, total cholesterol/high-density lipoprotein cholesterol ratio (TC/HDL-C), N-terminal pro-brain natriuretic peptide (NT-proBNP) and insulin resistance (IR) patients with early RA treated two different treat-to-target strategies.
To characterise the dynamic of events during early phases fracture repair in humans, we investigated molecular using gene expression profiling bone fragments from site at different time points after trauma and immune/stromal cells recruitment flow cytometry. Bone inflammatory markers were expressed low levels homeostasis, while transcripts for constituent proteins consistently detected higher levels. Early (range 2–4 days), increased CXCL12, suggested immune associated with a change balance...
Objective Gene expression profiles are associated with the clinical heterogeneity of systemic lupus erythematosus (SLE) but not well studied as biomarkers for therapy. We gene and response to rituximab in a multiethnic UK cohort who were refractory standard Methods evaluated baseline levels transcripts known associate features SLE using 96‐probe TaqMan array whole blood samples from 213 patients active had been prospectively enrolled British Isles Lupus Assessment Group (BILAG) Biologics...