Giuseppe Mandraffino
A5081405968- Lipoproteins and Cardiovascular Health
- Cardiovascular Health and Disease Prevention
- Cancer, Lipids, and Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Proteoglycans and glycosaminoglycans research
- Cardiovascular Function and Risk Factors
- Angiogenesis and VEGF in Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Lipid metabolism and disorders
- Inflammation biomarkers and pathways
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Blood Pressure and Hypertension Studies
- MicroRNA in disease regulation
- Cardiac Imaging and Diagnostics
- Systemic Lupus Erythematosus Research
- Biomarkers in Disease Mechanisms
- Vitamin D Research Studies
- Hormonal Regulation and Hypertension
- Health Systems, Economic Evaluations, Quality of Life
- Osteoarthritis Treatment and Mechanisms
- Frailty in Older Adults
- Cardiovascular Disease and Adiposity
- Pancreatitis Pathology and Treatment
- Venous Thromboembolism Diagnosis and Management
- Coronary Interventions and Diagnostics
University of Messina
2016-2025
Azienda Ospedaliera Universitaria Policlinico "G. Martino"
2013-2022
Weatherford College
2022
European Atherosclerosis Society
2021
Ospedale Policlinico San Martino
2017
University of Pisa
2016
American Physical Therapy Association
2010
Background: Adverse drug reactions (ADRs) are an important public health problem, representing a major cause of morbidity and mortality. However, several countries have no recent studies available. Since 2014, prospective active pharmacovigilance project, aimed to improve ADRs monitoring in hospital wards (FORWARD) was performed Sicily. This study, as part FORWARD describe occurred during the stay Internal Medicine wards. related admission, characteristics preventability were also evaluated....
Conventional transthoracic echocardiography (TTE) and tissue Doppler imaging (TDI) are usually unable to reveal very early subtle abnormalities in left ventricular (LV) systolic function caused by hypertension, prior manifestation of hypertrophy (LVH). This study was undertaken assess whether speckle tracking (STE) provides more insight into hypertension-induced LV dysfunction, with the purpose identifying patients at higher risk for heart failure (HF).Fifty-one (56.5 ± 14 years) 51 controls...
Arterial stiffness is an important determinant of cardiovascular risk. It associated with several risk factors, including hypertension, diabetes and cigarette smoking. However, there are conflicting data about the relationship between arterial hypercholesterolemia. Furthermore, augmentation index (AIx), a measure systemic stiffness, has not been previously investigated in hypercholesterolemic (HCh) children. Aim our study was to evaluate local as well carotid intima-media thickness (IMT) HCh...
Familial hypercholesterolemia (FH) is an autosomal dominant disease characterized by elevated plasma levels of LDL-cholesterol that confers increased risk premature atherosclerotic cardiovascular disease. Early identification and treatment FH patients can improve prognosis reduce the burden mortality. Aim this study was to perform mutational analysis identified through a collaboration 20 Lipid Clinics in Italy (LIPIGEN Study). We recruited 1592 individuals with clinical diagnosis definite or...
Primary dyslipidemias are a heterogeneous group of disorders characterized by abnormal levels circulating lipoproteins. Among them, familial hypercholesterolemia is the most common lipid disorder that predisposes for premature cardiovascular disease. We set up an Italian nationwide network aimed at facilitating clinical and genetic diagnosis named LIPIGEN (LIpid TransPort Disorders GEnetic Network). Observational, multicenter, retrospective prospective study involving about 40 centers....
Background Evidence suggests that LPA risk genotypes are a possible contributor to the clinical diagnosis of familial hypercholesterolemia (FH). This study aimed at determining prevalence variants in adult individuals with FH enrolled Italian LIPIGEN (Lipid Transport Disorders Genetic Network) study, (FH/M+) or without (FH/M-) causative genetic variant. Methods and Results An lp(a) [lipoprotein(a)] score was calculated by summing number risk-increasing alleles inherited rs3798220 rs10455872...
Abstract Aims The availability of novel lipid-lowering therapies (LLTs) has remarkably changed the clinical management homozygous familial hypercholesterolaemia (HoFH). impact these advances was evaluated in a cohort 139 HoFH patients followed real-world setting. Methods and results characteristics patients, along with information about LLTs low-density lipoprotein cholesterol (LDL-C) levels at baseline after median follow-up 5 years, were retrospectively retrieved from records enrolled...
Background and Aims Suboptimal vitamin D status was recently acknowledged as an independent predictor of cardiovascular diseases all-cause mortality in several clinical settings, its serum levels are commonly reduced Rheumatoid Arthritis (RA). Patients affected by RA present accelerated atherosclerosis increased morbidity with respect to the general population. In RA, it has been reported impairment number activity circulating proangiogenic haematopoietic cells (PHCs), including CD34+, that...
Abstract Background Patients with inflammatory bowel disease (IBD) have an increased cardiovascular risk (CVR) and (CVD) is the leading cause of mortality in IBD patients. A more in-depth screening patients has become important EMA warning for JAK-inhibitors. The current CV stratification algorithms are based on traditional factors not considering subclinical atherosclerosis. This study aimed to stratify CVR according European Society Cardiology (ESC 2021/23) Atherosclerosis (EAS), together...
Background: Sepsis is a critical condition characterized by severe immune dysregulation, ranking among the leading causes of morbidity and mortality in intensive care internal medicine units. Nutritional status plays pivotal role modulating these responses, as when inadequate it can compromise defenses, body's ability to handle stress inflammation, clinical course. Malnutrition frequently observed septic patients strongly associated with worse outcomes, including increased mortality,...
Background: Awareness, diagnosis, and treatment of familial hypercholesterolemia (FH) starting from childhood are a cornerstone cardiovascular disease prevention. The LIPIGEN Paediatric Group, network specialised centres for the diagnosis management genetic dyslipidemia, is an active part this mission. Materials Methods: This second exploratory survey organised within (LIpid transPort disorders Italian GEnetic Network) paediatric centres. A digital questionnaire consisting 16 questions was...
Abstract Background. It is unknown how much precociously the cigarette smoking (CS) may compromise integrity of cardiovascular (CV) system. Myocardial function can be routinely assessed by conventional echocardiography, but abnormalities are only detected when somewhat a remodelling has already occurred. These limitations could overcome strain imaging. Methods. We evaluated whether young smokers with normal left ventricular (LV) geometry, wall motion and ejection fraction present in...
Background A significant proportion of individuals clinically diagnosed with familial hypercholesterolemia (FH), but without any disease-causing mutation, are likely to have polygenic hypercholesterolemia. We evaluated the distribution a risk score, consisting 12 low-density lipoprotein cholesterol (LDL-C)-raising variants (polygenic LDL-C score), in subjects clinical diagnosis FH. Methods and Results Within Lipid Transport Disorders Italian Genetic Network (LIPIGEN) study, 875 patients who...