A5083623149- Pancreatic function and diabetes
- Lipoproteins and Cardiovascular Health
- Diabetes and associated disorders
- Diabetes Management and Research
- Diet and metabolism studies
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Vitamin D Research Studies
- Health Systems, Economic Evaluations, Quality of Life
- Eating Disorders and Behaviors
- Diabetes, Cardiovascular Risks, and Lipoproteins
Agostino Gemelli University Polyclinic
2018
Università Cattolica del Sacro Cuore
2015-2018
Familial hypercholesterolemia (FH) is an autosomal dominant disease characterized by elevated plasma levels of LDL-cholesterol that confers increased risk premature atherosclerotic cardiovascular disease. Early identification and treatment FH patients can improve prognosis reduce the burden mortality. Aim this study was to perform mutational analysis identified through a collaboration 20 Lipid Clinics in Italy (LIPIGEN Study). We recruited 1592 individuals with clinical diagnosis definite or...
Objective The aim was to investigate whether vitamin D supplementation, combined with a hypocaloric diet, could have an independent effect on insulin sensitivity in subjects both overweight and hypovitaminosis D. Changes from baseline anthropometric parameters, body composition, glucose tolerance, secretion were considered as secondary outcomes. Methods Eighteen volunteers who nondiabetic deficient had BMI > 25 kg/m 2 randomized (1:1) double‐blind manner diet + either oral cholecalciferol...
Increased proinsulin secretion, which characterizes type 2 diabetes and insulin resistance, may be due to an intrinsic, primitive defect in processing or secondary increased demand on β-cells (hyperinsulinemia resistance). An alternative way investigate the relation between relative hyperproinsulinemia secretory is study dynamic changes proinsulin-to-insulin ratio after partial pancreatectomy, a model of acute β-cell workload remaining pancreas. To pursue this aim, patients without diabetes,...
Insulin resistance impacts virtually all tissues, including pancreatic β cells. Individuals with insulin resistance, but without diabetes, exhibit an increased islet size because of elevated number both and α Neogenesis from duct cells transdifferentiation have been postulated to contribute the β-cell compensatory response resistance.Our objective was explore parameters that could potentially predict altered morphology.We investigated 16 nondiabetic subjects by a 2-hour hyperglycemic clamp...