Manlio Cipriani

ORCID: 0000-0002-0632-0561
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About
Contact & Profiles
Research Areas
  • Cardiac Structural Anomalies and Repair
  • Mechanical Circulatory Support Devices
  • Viral Infections and Immunology Research
  • Heart Failure Treatment and Management
  • Transplantation: Methods and Outcomes
  • Cardiovascular Function and Risk Factors
  • Cardiac pacing and defibrillation studies
  • Cardiac Valve Diseases and Treatments
  • Cardiac Arrest and Resuscitation
  • COVID-19 Clinical Research Studies
  • Long-Term Effects of COVID-19
  • Cardiovascular Effects of Exercise
  • Cardiac Imaging and Diagnostics
  • Eosinophilic Disorders and Syndromes
  • Cardiomyopathy and Myosin Studies
  • Health Systems, Economic Evaluations, Quality of Life
  • Cardiac Arrhythmias and Treatments
  • Potassium and Related Disorders
  • Diabetes Treatment and Management
  • Infective Endocarditis Diagnosis and Management
  • COVID-19 and healthcare impacts
  • Intensive Care Unit Cognitive Disorders
  • Atrial Fibrillation Management and Outcomes
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Lipoproteins and Cardiovascular Health

Istituto Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione
2022-2025

Istituti di Ricovero e Cura a Carattere Scientifico
2017-2025

Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda
2014-2023

Ospedale Maggiore
2015-2022

Associazione Nazionale Medici Cardiologi Ospedalieri
2017-2022

Azienda Sanitaria Universitaria Integrata di Trieste
2022

Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico
2019-2021

Metropolitana Milanese (Italy)
2019

Società Italiana di Reumatologia
2018

Don Carlo Gnocchi Foundation
2018

There is controversy about the outcome of patients with acute myocarditis (AM), and data are lacking on how admitted suspected AM managed. We report characteristics, in-hospital management, long-term based a retrospective multicenter registry from 19 Italian hospitals.A total 684 recent onset symptoms (<30 days) were screened between May 2001 February 2017. Patients >70 years age those >50 without coronary angiography excluded. The final study population comprised 443 (median age, 34 years;...

10.1161/circulationaha.118.035319 article EN Circulation 2018-05-15

Previous reports have suggested that despite their dramatic presentation, patients with fulminant myocarditis (FM) might better outcome than those acute nonfulminant (NFM). In this retrospective study, we report and changes in left ventricular ejection fraction (LVEF) a large cohort of FM compared NFM.The study population consists 187 consecutive admitted between May 2001 November 2016 diagnosis (onset symptoms <1 month) whom 55 required inotropes and/or mechanical circulatory support the...

10.1161/circulationaha.117.026386 article EN Circulation 2017-06-03

Acute myocarditis (AM) is thought to be a rare cardiovascular complication of COVID-19, although minimal data are available beyond case reports. We aim report the prevalence, baseline characteristics, in-hospital management, and outcomes for patients with COVID-19-associated AM on basis retrospective cohort from 23 hospitals in United States Europe.A total 112 suspected 56 963 hospitalized COVID-19 were evaluated between February 1, 2020, April 30, 2021. Inclusion criteria hospitalization...

10.1161/circulationaha.121.056817 article EN Circulation 2022-04-11

Myocarditis is an inflammatory disease of the myocardium with a broad spectrum clinical presentations, ranging from mild symptoms to severe heart failure. The course patients myocarditis heterogeneous, varying partial or full recovery in few days advanced low cardiac output syndrome requiring mechanical circulatory support transplantation. Fulminant (FM) peculiar condition and acute form myocarditis, whose main characteristic rapidly progressive need for hemodynamic support. Despite common...

10.14744/anatoljcardiol.2017.8170 article EN cc-by-nc The Anatolian Journal of Cardiology 2018-01-01

Neuromuscular diseases (NMDs) encompass various hereditary conditions affecting motor neurons, the neuromuscular junction, and skeletal muscles. These disorders are characterized by progressive muscle weakness can manifest at different stages of life, from birth to adulthood. NMDs, such as Duchenne Becker muscular dystrophies, myotonic dystrophy, limb–girdle often involve cardiac complications, including cardiomyopathies arrhythmias. Underlying genetic mutations contribute dysfunction,...

10.3390/cardiogenetics15010007 article EN cc-by Cardiogenetics 2025-03-03

Background: Gastrointestinal bleeding (GIB) is a common complication of left ventricular assist device (LVAD) support. The UTAH risk score (UBRS) the only dedicated GIB prediction model, but its efficacy has not been confirmed in an external validation cohort. Furthermore, reliability other scores, such as ARC-HBR and HASBLED, never tested this specific population. This study aims to validate UBRS compare accuracy with HASBLED scores. Methods: Major adverse events (MAEs) 75 consecutive...

10.3390/jcdd12030105 article EN cc-by Journal of Cardiovascular Development and Disease 2025-03-19

Introduction: The mitral valve annulus naturally adopts a saddle shape in systole, likely concentrating systolic stress on the commissures where fibrous trigones are located. This study hypothesized that patients with dilated cardiomyopathies, is large and planar, would be redirected. Methods: Computational modeling was employed to compare distribution saddle-shaped valves (n.10 patients) planar annuli seen cardiomyopathy using kinematics of from systole diastole extrapolated computed...

10.3389/fphys.2025.1532972 article EN cc-by Frontiers in Physiology 2025-03-25

Heart failure is the leading cardiovascular cause of hospitalization with an increasing prevalence, especially in older patients. About 50% patients heart have preserved ventricular function, a form that, until few years ago, was orphaned by pharmacological treatments effective reducing and mortality. New trials, which tested use gliflozins ejection fraction (HFpEF), for first time demonstrated their effectiveness changing natural history this insidious frequent failure. Therefore,...

10.1714/4464.44616 article EN PubMed 2025-04-01

Aims Patients with heart failure (HF) remain often undertreated for multiple reasons, including treatment inertia, contraindications, and intolerance. The OPTIimal PHARMacological therapy patients Heart Failure (OPTIPHARM‐HF) registry is designed to evaluate the prevalence of evidence‐based medical prescription titration, as well causes its underuse, in a broad real‐world population consecutive HF across whole ejection fraction spectrum among different clinical phenotypes. Methods...

10.1002/ejhf.3260 article EN cc-by-nc-nd European Journal of Heart Failure 2024-06-23

In order to assess the value of exercise thallium scintigraphy for detection and prognosis graft coronary artery disease, 50 heart transplant patients (mean age 46.7 +/- 11.5 years) were studied within 48 h their scheduled yearly angiography subsequently followed up a mean 13 3 months. Angiography revealed normal arteries in 35 patients, disease 15 (two with type A lesions, seven B lesions six both). Seven had one or more stenoses > = 50%. Exercise was negative all (100% specificity),...

10.1093/eurheartj/14.2.226 article EN European Heart Journal 1993-02-02

The aim of the present study was to assess association presence and amount late gadolinium enhancement (LGE) at cardiac magnetic resonance (CMR) with cardiovascular adverse events in patients orthotopic heart transplantation (HTx). We enrolled 48 (mean age, 54.7 ± 14.6 years; 37 men) various stages after HTx. All underwent standard CMR 1.5 T, characterize both anatomy LGE. Late detected 26 (54%). All-cause mortalities, a composite major (MACE) recurrence were evaluated during follow-up...

10.1093/ehjci/jew186 article EN European Heart Journal - Cardiovascular Imaging 2016-09-13

Background Persistent left ventricular (LV) systolic dysfunction in patients with acute lymphocytic myocarditis (LM) is widely unexplored. Objectives To assess the frequency and predictors of persistent LV LM reduced LVEF at admission. Methods results We retrospectively evaluated 89 consecutive histologically-proven enrolled three Italian referral hospitals. A subgroup 48 LM, baseline impairment an available echocardiographic assessment 12 months (6–18) from discharge constituted study...

10.1371/journal.pone.0214616 article EN cc-by PLoS ONE 2019-03-28
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