A5049762776- Mesenchymal stem cell research
- Cancer Treatment and Pharmacology
- Neurogenesis and neuroplasticity mechanisms
- Nerve injury and regeneration
- Pancreatic function and diabetes
- Glioma Diagnosis and Treatment
- Microtubule and mitosis dynamics
- Diabetes Management and Research
- Neuroblastoma Research and Treatments
- Multiple Myeloma Research and Treatments
- PARP inhibition in cancer therapy
- Histone Deacetylase Inhibitors Research
- Neuroscience and Neuropharmacology Research
- Pharmacological Receptor Mechanisms and Effects
- Cell death mechanisms and regulation
- Pluripotent Stem Cells Research
- Tissue Engineering and Regenerative Medicine
- Neurological Disease Mechanisms and Treatments
- Melanoma and MAPK Pathways
- Mitochondrial Function and Pathology
- Receptor Mechanisms and Signaling
- Angiogenesis and VEGF in Cancer
- Sirtuins and Resveratrol in Medicine
- Peripheral Neuropathies and Disorders
- Spinal Cord Injury Research
University of Milano-Bicocca
2015-2024
Fondazione IRCCS Istituto Neurologico Carlo Besta
2019
University of Milan
2005-2013
University of Messina
1992-2004
The clinical usability of pancreatic islet transplantation for the treatment type I diabetes, despite some encouraging results, is currently hampered by short lifespan transplanted tissue. In vivo studies have demonstrated that co-transplantation Mesenchymal Stem Cells (MSCs) with islets more effective respect to alone in ensuring glycemia control diabetic rats, but molecular mechanisms this action are still unclear. aim study was elucidate positive effect MSCs on functionality setting up...
Adipocytes' biology and the mechanisms that control adipogenesis have gained importance because of need to develop therapeutic strategies obesity related pathologies. Human mesenchymal stem cells (hMSCs), undifferentiated present in bone marrow are physiological precursors adipocytes, were induced adipogenic differentiation. The molecular on basis evaluated, focusing MAPKinases ERK1 ERK2, which involved many biological cellular processes. ERK2 phosphorylation was reduced with different...
Cellular therapies using Mesenchymal Stem Cells (MSCs) represent a promising approach for the treatment of degenerative diseases, in particular mesengenic tissue regeneration. However, before approval clinical trials humans, vitro studies must be performed aimed at investigating MSCs' biology and mechanisms regulating their proliferation differentiation abilities. Besides on human MSCs (hMSCs), derived from rodents have been most used cellular type studies. Nevertheless, transfer results...
Oxaliplatin (OHP)-induced peripheral neurotoxicity (OIPN) is a frequent adverse event of colorectal cancer treatment. OIPN encompasses chronic and an acute syndrome. The latter consists transient axonal hyperexcitability, due to unbalance in Na+ voltage-operated channels (Na+VOC). This leads sustained depolarisation which can activate the reverse mode Na+/Ca2+ exchanger 2 (NCX2), resulting toxic Ca2+ accumulation damage (ADa). We explored role NCX2 vitro vivo settings. Embryonic rat Dorsal...
Chemotherapy-induced peripheral neurotoxicity is one of the most common dose-limiting toxicities several widely used anticancer drugs such as platinum derivatives (cisplatin) and taxanes (paclitaxel). Several molecular mechanisms related to onset have already been proposed, them having sensory neurons dorsal root ganglia (DRG) nerve fibers principal targets. In this study we explore chemotherapy-induced beyond neuronocentric view, investigating changes induced by paclitaxel (PTX) cisplatin...
Effective therapies for multiple sclerosis (MS) are still missing. This neurological disease affects more than 2.5 million people worldwide. To date, biological immunomodulatory drugs effective and safe during short-term treatment, but they suitable only parenteral administration expensive. Accordingly, academic industrial environments focusing their efforts toward the development of new MS drugs. Considering that neurodegeneration is a contributory factor in onset MS, herein we will focus...